Results 11 to 20 of about 298,488 (253)

Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf [PDF]

, 2016
The pharmacokinetic (PK) profile of tulathromycin, administered to calves subcutaneously at the dosage of 2.5 mg/kg, was established in serum, inflamed (exudate), and noninflamed (transudate) fluids in a tissue cage model. The PK profile of tulathromycin
Aliabadi, Anonymous, Bosnar, Committee for Medicinal Products for Human Use (CHMP), Committee for Medicinal Products for Veterinary Use (CVMP), Evans, Gladue, Godinho, Godinho, Higgins, Huang, Karlsson, Kiem, Lees, Mandell, Menge, Mouton, Muller, Nowakowski, Roof, Sarasola, Schentag, Scheuch, Scorneaux, Scorneaux, Sidhu, Thomas, Toutain, Toutain, Toutain, Toutain, Villarino, Villarino, Villarino, Villarino, Waag   +35 more
core   +4 more sources

α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries [PDF]

, 2013
The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved.
Alexander, Arévalo-León, Cavalli, Chalothorn, Chen, Cotecchia, Daly, Deighan, Docherty, García-Cazarín, García-Sainz, García-Sainz, García-Sainz, Gisbert, Gisbert, Gisbert, Gisbert, Goldstein, Hawrylyshyn, Hein, Hosoda, Hrometz, Hussain, Keffel, Kenny, Koshimizu, Lachnit, Lyssand, Lyssand, Lyssand, Martinez-Rivelles, Martí, McCune, Methven, Methven, Michelotti, Monto, Noguera, Noguera, Philipp, Piascik, Piascik, Pérez-Aso, Rudner, Schwinn, Stassen, Taguchi, Tanaka, Tanoue, Tanoue, Theroux, Yamamoto, Zhong, Ziani   +53 more
core   +1 more source

A large potentiation effect of serum on the in vitro potency of tulathromycin against Mannheimia haemolytica and Pasteurella multocida [PDF]

, 2016
The antimicrobial properties of tulathromycin were investigated for M.haemolytica and P.multocida. Three invitro indices of antimicrobial activity, minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill curves ...
Alexander, Andersen, Brentnall, Craig, Evans, Ferran, Godinho, Godinho, Godinho, Kesteman, Kiem, Mitchell, Mitchell, Nickell, Nightingale, Nowakowski, Perrett, Portis, Pruul, Radostits, Rerat, Robb, Rose, Schunicht, Step, Torres, Toutain, Tyndall, Van Donkersgoed, Van Donkersgoed, Villarino, Wellman, Zeitlinger, Zeitlinger   +33 more
core   +3 more sources

Ligand-Specific Regulation of the Endogenous Mu-Opioid Receptor by Chronic Treatment with Mu-Opioid Peptide Agonist [PDF]

, 2013
Since the discovery of the endomorphins (EM), the postulated endogenous peptide agonists of the mu-opioid receptors, several analogues have been synthesized to improve their binding and pharmacological profiles.
Birkás, Erika, Bozó, Beáta, Cinar, Resat, Dochnal, Roberta Beatrix, Fábián, Gabriella, Kicsi, Emese Gabriella, Kékesi, Orsolya, Murányi, Marianna, Mácsai, Mónika, Szabó, Gyula, Szűcs, Mária, Tóth, Géza, Zentai, András   +12 more
core   +3 more sources

Gastroesophageal reflux disease and tooth erosion [PDF]

, 2011
The increasing prevalence of gastroesophageal reflux disease (GERD) in children and adults, and of “silent refluxers” in particular, increases the responsibility of dentists to be alert to this potentially severe condition when observing unexplained ...
Kaidonis, J., Ranjitkar, S., Smales, R.
core   +4 more sources

Association between high dietary intake of the n-3 polyunsaturated fatty acid docosahexaenoic acid and reduced risk of Crohn's disease [PDF]

, 2014
Background: There are plausible mechanisms for how dietary docosahexaenoic acid (DHA), an n−3 polyunsaturated fatty acid, could prevent Crohn's disease (CD).
Abraham, Ananthakrishnan, Ananthakrishnan, Ananthakrishnan, Arita, Bartoli, Belluzzi, Bingham, Burdge, Chan, Charpentier, Corey, Depner, Feagan, Fritsche, Goldbohm, Goldman, Hommes, Jostins, Kaaks, Levy, Novak, Rao, Riboli, Rodriguez-Lagunas, Sakamoto, Salem, Samuelsson, Serhan, Serini, Shivananda, Tjonneland, Turner, Watanabe, Weylandt, Yaqoob   +35 more
core   +1 more source

Potency of marbofloxacin for pig pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida: Comparison of growth media [PDF]

, 2017
Pharmacodynamic properties of marbofloxacin were established for six isolates each of the pig respiratory tract pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida.
Dorey, L, Hobson, S, Lees, P
core   +2 more sources

TSPO: kaleidoscopic 18-kDa amid biochemical pharmacology, control and targeting of mitochondria [PDF]

, 2016
The 18-kDa translocator protein (TSPO) localizes in the outer mitochondrial membrane (OMM) of cells and is readily up-regulated under various pathological conditions such as cancer, inflammation, mechanical lesions and neurological diseases. Able to bind
Aghazadeh, Aghazadeh, Alho, Amitani, Anholt, Anholt, Anholt, Anholt, Antkiewicz-Michaluk, Arbo, Banati, Banati, Bar-Ami, Barron, Basile, Batarseh, Batarseh, Batarseh, Batarseh, Batra, Beinlich, Benavides, Bernassau, Besman, Bird, Bitran, Bose, Boujrad, Boujrad, Braestrup, Bribes, Bribes, Brunette, Cagnin, Campanella, Campioli, Casellas, Chauveau, Chen, Chen, Cho, Clark, Colasanti, Corcia, Costa, Costa, Costa, Cuhlmann, Daugherty, De Souza, Decaudin, Decker, Delavoie, Delerive, Doperalski, Enders, Epstein, Fafalios, Fan, Fan, Fan, Fur, Fur, Galiegue, Gastaldello, Gatliff, Gatliff, Gavish, Gavish, Gazouli, Gehlert, Gerhard, Gervois, Giatti, Giatzakis, Giatzakis, Golani, Gonzalez-Polo, Guillon, Gulyas, Guo, Guo, Gut, Hardwick, Hardwick, Hauet, Hauet, Jamin, Jaremko, Jaremko, Jemma Gatliff, Joo, Joseph-Liauzun, Karlstetter, Kita, Kondo, Konigsrainer, Korkhov, Kreisl, Kruczek, Kumar, Lacapere, Lacapere, Lavisse, Li, Li, Li, Li, Li, Li, Libby, Liu, Liu, Maia, Maury, Mazurika, McEnery, Miao, Michelangelo Campanella, Midzak, Midzak, Miettinen, Miller, Mills, Mizrahi, Morohaku, Murail, Nagler, Obame, Oberto, Olson, Ostuni, Ouchi, Owen, Owen, Owen, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Papadopoulos, Paradis, Pastorino, Pelechano, Petrescu, Poynter, Raghavan, Rey, Romeo, Rone, Rosenberg, Rosenberg, Rosenberg, Rupprecht, Rupprecht, Scarf, Schaller, Selvaraj, Shoukrun, Sileikyte, Soustiel, Sutter, Tang, Taylor, Teboul, Thompson, Trincavelli, Tu, Tu, Tu, Vanhee, Varrone, Vega, Verma, Wang, Wang, Wei, Whalin, Xiao, Yang, Yang, Yasuno, Yeliseev, Yoder, Zhang, Zhang, Zhao, Zhou   +189 more
core   +1 more source

Reslizumab in patients with inadequately controlled late-onset asthma and elevated blood eosinophils [PDF]

, 2017
INTRODUCTION: Asthma with adult onset and elevated blood eosinophils is a difficult-to-treat subgroup. This post hoc analysis evaluated reslizumab, an anti-interleukin-5 monoclonal antibody, in patients with late-onset eosinophilic asthma.
Brusselle, Guy, Germinaro, Matthew, Weiss, Sivan, Zangrilli, James   +3 more
core   +2 more sources

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source