Results 21 to 30 of about 429,144 (355)

NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy

Journal for ImmunoTherapy of Cancer, 2021
Background NKTR-255 is a novel polyethylene glycol-conjugate of recombinant human interleukin-15 (rhIL-15), which was designed to retain all known receptor binding interactions of the IL-15 molecule. We explored the biologic and pharmacologic differences
Peter Kirk, Murali Addepalli, Thomas Chang, Palakshi Obalapur, Peiwen Kuo, Phi Quach, Jonathan Zalevsky, Rhoneil Pena, Saul Kivimae, Werner Rubas, Takahiro Miyazaki, Loui Madakamutil, Mekhala Maiti, Marlene Hennessy, Sara Sheibani, Joanna Wilczek, Janet Cetz, Andrew Moffett, Yinyan Tang, Jicai Huang, Dawei Sheng   +20 more
doaj   +1 more source

Advancing pharmacometrics and systems pharmacology. [PDF]

, 2012
Pharmacometrics and systems pharmacology are emerging as principal quantitative sciences within drug development and experimental therapeutics. In recognition of the importance of pharmacometrics and systems pharmacology to the discipline of clinical ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources

Transfer of rhodamine-123 into the brain and cerebrospinal fluid of fetal, neonatal and adult rats

Fluids and Barriers of the CNS, 2021
Background Adenosine triphosphate binding cassette transporters such as P-glycoprotein (PGP) play an important role in drug pharmacokinetics by actively effluxing their substrates at barrier interfaces, including the blood-brain, blood-cerebrospinal ...
Liam M. Koehn, Katarzyna M. Dziegielewska, Mark D. Habgood, Yifan Huang, Norman R. Saunders   +4 more
doaj   +1 more source

Personalized medicine : the impact on chemistry [PDF]

, 2010
An effective strategy for personalized medicine requires a major conceptual change in the development and application of therapeutics. In this article, we argue that further advances in this field should be made with reference to another conceptual shift,
Marsh, Andrew, Singer, Donald R. J., Taylor, Paul C., Watkins, John   +3 more
core   +1 more source

Peer Review Certifies Quality and Innovation in Clinical Pharmacology & Therapeutics. [PDF]

, 2017
Clinical Pharmacology & Therapeutics (CPT) is an established voice of the discipline, a trusted source of new knowledge showcasing discovery, translation, and application of novel therapeutic paradigms to advance the management of patients and ...
Terzic, Andre M., Waldman, Scott A.
core   +2 more sources

Pharmacokinetic/pharmacodynamic integration and modelling of oxytetracycline for the porcine pneumonia pathogens Actinobacillus pleuropneumoniae and Pasteurella multocida [PDF]

, 2017
Pharmacokinetic–pharmacodynamic (PK/PD) integration and modelling were used to predict dosage schedules of oxytetracycline for two pig pneumonia pathogens, Actinobacillus pleuropneumoniae and Pasteurella multocida.
Aliabadi, Aliabadi, Blondeau, Brentnall, Brentnall, Cadwell, Dorey, Honeyman, Illambas, Illambas, Jong, Lees, Lees, Lees, Lees, Martinez, Mouton, Mouton, Nielsen, Nielsen, Nightingale, Nouws, Nouws, Nyberg, Papich, Potter, Rey, Sidhu, Sidhu, Toutain, Toutain, Toutain, Toutain, Vilalta, Yoshimura   +34 more
core   +1 more source

Ameliorative effect of ethanol extract of Eragrostis tremula Hochst. ex Steud. against diazepam-induced amnesia in mice

Bulletin of the National Research Centre, 2022
Background Eragrostis tremula Hochst. ex Steud. (Poaceae) is used in ethno-medicine as a memory enhancer. Studies have shown that the whole plant possesses memory enhancing potentials and could be beneficial in the management of amnesia and cognitive ...
Abdullahi Balarabe Nazifi, Abdulhakim Abubakar, Mohammed Garba Magaji, Musa Aliyu, Nuhu Mohammed Danjuma   +4 more
doaj   +1 more source

Standard PK/PD concepts can be applied to determine a dosage regimen for a macrolide: the case of tulathromycin in the calf [PDF]

, 2016
The pharmacokinetic (PK) profile of tulathromycin, administered to calves subcutaneously at the dosage of 2.5 mg/kg, was established in serum, inflamed (exudate), and noninflamed (transudate) fluids in a tissue cage model. The PK profile of tulathromycin
Aliabadi, Anonymous, Bosnar, Committee for Medicinal Products for Human Use (CHMP), Committee for Medicinal Products for Veterinary Use (CVMP), Evans, Gladue, Godinho, Godinho, Higgins, Huang, Karlsson, Kiem, Lees, Mandell, Menge, Mouton, Muller, Nowakowski, Roof, Sarasola, Schentag, Scheuch, Scorneaux, Scorneaux, Sidhu, Thomas, Toutain, Toutain, Toutain, Toutain, Villarino, Villarino, Villarino, Villarino, Waag   +35 more
core   +1 more source

USP52 regulates DNA end resection and chemosensitivity through removing inhibitory ubiquitination from CtIP

Nature Communications, 2020
C-terminal binding protein (CtBP) interacting protein (CtIP) is a fundamental factor for the initiation of DNA end resection to initiate DNA repair. Here the authors reveal mechanistic insights into the regulation of CtIP via the deubiquitinase USP52.
Ming Gao, Guijie Guo, Jinzhou Huang, Jake A. Kloeber, Fei Zhao, Min Deng, Xinyi Tu, Wootae Kim, Qin Zhou, Chao Zhang, Ping Yin, Kuntian Luo, Zhenkun Lou   +12 more
doaj   +1 more source

Curcumin as a Natural Remedy for Atherosclerosis: A Pharmacological Review

Molecules, 2021
Curcumin, a natural polyphenolic compound present in Curcuma longa L. rhizomes, shows potent antioxidant, anti-inflammatory, anti-cancer, and anti-atherosclerotic properties.
Laxman Singh, Shikha Sharma, Suowen Xu, Devesh Tewari, Jian Fang   +4 more
doaj   +1 more source