Results 31 to 40 of about 429,144 (355)

Reversal of hepatorenal syndrome type 1 with terlipressin plus albumin vs. placebo plus albumin in a pooled analysis of the OT-0401 and REVERSE randomised clinical studies [PDF]

, 2017
Background The goal of hepatorenal syndrome type 1 (HRS-1) treatment is to improve renal function. Terlipressin, a synthetic vasopressin analogue, is a systemic vasoconstrictor used for the treatment of HRS-1, where it is available.
Araya, V., Boyer, T. D., Escalante, S., Frederick, R. T., Jamil, K., Pappas, S. C., Reddy, K. R., Rossaro, L., Sanyal, A. J., Teuber, P., Vargas, H. E., Wong, F.   +11 more
core   +2 more sources

Effects of paracetamol (acetaminophen) on gene expression and permeability properties of the rat placenta and fetal brain [version 2; peer review: 2 approved]

F1000Research, 2020
Background: Paracetamol (acetaminophen) is widely used in pregnancy and generally regarded as “safe” by regulatory authorities. Methods: Clinically relevant doses of paracetamol were administered intraperitoneally to pregnant rats twice daily from ...
Liam M. Koehn, Yifan Huang, Mark D Habgood, Kai Kysenius, Peter J. Crouch, Katarzyna M Dziegielewska, Norman R Saunders   +6 more
doaj   +1 more source

Identifying glycan consumers in human gut microbiota samples using metabolic labeling coupled with fluorescence-activated cell sorting

Nature Communications, 2023
Dietary glycans are a major driver of the human gut microbiota composition. Here, the authors apply next-generation metabolic labeling coupled with fluorescence-activated cell sorting to identify and isolate gut bacteria consumers of dietary glycans in ...
Lharbi Dridi, Fernando Altamura, Emmanuel Gonzalez, Olivia Lui, Ryszard Kubinski, Reilly Pidgeon, Adrian Montagut, Jasmine Chong, Jianguo Xia, Corinne F. Maurice, Bastien Castagner   +10 more
doaj   +1 more source

α1D-Adrenoceptors are responsible for the high sensitivity and the slow time-course of noradrenaline-mediated contraction in conductance arteries [PDF]

, 2013
The objective of this study was to determine whether the different time-course characteristics of α1-adrenoceptor-mediated contraction in arteries can be related to the subtypes involved.
Alexander, Arévalo-León, Cavalli, Chalothorn, Chen, Cotecchia, Daly, Deighan, Docherty, García-Cazarín, García-Sainz, García-Sainz, García-Sainz, Gisbert, Gisbert, Gisbert, Gisbert, Goldstein, Hawrylyshyn, Hein, Hosoda, Hrometz, Hussain, Keffel, Kenny, Koshimizu, Lachnit, Lyssand, Lyssand, Lyssand, Martinez-Rivelles, Martí, McCune, Methven, Methven, Michelotti, Monto, Noguera, Noguera, Philipp, Piascik, Piascik, Pérez-Aso, Rudner, Schwinn, Stassen, Taguchi, Tanaka, Tanoue, Tanoue, Theroux, Yamamoto, Zhong, Ziani   +53 more
core   +1 more source

Forensic pharmacology: An important and evolving subspecialty needs recognition in India

Journal of Pharmacy and Bioallied Sciences, 2016
With training in pharmacology, a pharmacologist has an expert knowledge as well as working experience in the subjects of therapeutics, pharmacokinetics, and toxicology along with exposure to subjects such as forensic medicine during the medical education.
Harshad Onkarrao Malve
doaj   +1 more source

Muscle‐directed gene therapy corrects Pompe disease and uncovers species‐specific GAA immunogenicity

EMBO Molecular Medicine, 2021
Pompe disease is a severe disorder caused by loss of acid α‐glucosidase (GAA), leading to glycogen accumulation in tissues and neuromuscular and cardiac dysfunction. Enzyme replacement therapy is the only available treatment. AT845 is an adeno‐associated
Michelle Eggers, Charles H Vannoy, Jianyong Huang, Pravinkumar Purushothaman, Jacqueline Brassard, Carlos Fonck, Hui Meng, Mariah J Prom, Michael W Lawlor, Justine Cunningham, Chanchal Sadhu, Fulvio Mavilio   +11 more
doaj   +1 more source

Pharmacology and Therapeutics of Bronchodilators Revisited [PDF]

Pharmacological Reviews, 2020
Bronchodilators remain the cornerstone of the treatment of airway disorders such as asthma and chronic obstructive pulmonary disease (COPD). There is therefore considerable interest in understanding how to optimize the use of our existing classes of bronchodilator and in identifying novel classes of bronchodilator drugs.
Matera, M G, Page, C P, Calzetta, L, Rogliani, P, Cazzola, M   +4 more
openaire   +4 more sources

Process Improvement for Maximized Therapeutic Innovation Outcome. [PDF]

, 2017
Deconvoluting key biological mechanisms forms the framework for therapeutic discovery. Strategies that enable effective translation of those insights along the development and regulatory path ultimately drive validated clinical application in patients ...
Terzic, Andre, Waldman, Scott A.
core   +2 more sources

Antimalarial pharmacology and therapeutics of atovaquone [PDF]

Journal of Antimicrobial Chemotherapy, 2013
Atovaquone is used as a fixed-dose combination with proguanil (Malarone) for treating children and adults with uncomplicated malaria or as chemoprophylaxis for preventing malaria in travellers. Indeed, in the USA, between 2009 and 2011, Malarone prescriptions accounted for 70% of all antimalarial pre-travel prescriptions.
David G. Lalloo, Darren M. Moss, Gemma L. Nixon, Stephen A. Ward, Alison E. Shone, Paul M. O'Neill, Nicholas Fisher, Giancarlo A. Biagini   +7 more
openaire   +4 more sources

Interaction between Cannabinoid System and Toll-Like Receptors Controls Inflammation [PDF]

, 2016
Since the discovery of the endocannabinoid system consisting of cannabinoid receptors, endogenous ligands, and biosynthetic and metabolizing enzymes, interest has been renewed in investigating the promise of cannabinoids as therapeutic agents.
McCoy, Kathleen L.
core   +4 more sources