Results 141 to 150 of about 1,429,081 (399)

ELECTRO-THERAPEUTICS. [PDF]

The Lancet, 1877
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openaire   +2 more sources

Natural selection and genetic variation in a promising Chagas disease drug target: Trypanosoma cruzi trans-sialidase [PDF]

, 2017
Rational drug design is a powerful method in which new and innovative therapeutics can be designed based on knowledge of the biological target aiming to provide more efficacious and responsible therapeutics.
Gallant, Joseph P.
core   +1 more source

Cell‐free and extracellular vesicle microRNAs with clinical utility for solid tumors

Molecular Oncology, EarlyView.
Cell‐free microRNAs (cfmiRs) are small‐RNA circulating molecules detectable in almost all body biofluids. Innovative technologies have improved the application of cfmiRs to oncology, with a focus on clinical needs for different solid tumors, but with emphasis on diagnosis, prognosis, cancer recurrence, as well as treatment monitoring.
Yoshinori Hayashi, Janelle‐Cheri Millen, Romela Irene Ramos, Jennifer A. Linehan, Timothy G. Wilson, Dave S. B. Hoon, Matias A. Bustos   +6 more
wiley   +1 more source

At the edge of individual cognitive-behavioural policies: how to walk the public health path to effectively improve population health?

Salud Pública de México, 2013
Most countries worldwide have recognised the significance of contextual social determinants of health (SDH) on population health. This essay challenges current public health views focused on individual risk-factors and motivates an  evidenceinformed ...
Baltica Cabieses
doaj   +1 more source

ECCO Guidelines on Therapeutics in Crohn's Disease: Surgical Treatment.

Journal of Crohn's & Colitis, 2019
This article is the second in a series of two publications relating to the European Crohn's and Colitis Organisation [ECCO] evidence-based consensus on the management of Crohn's disease.
M. Adamina, S. Bonovas, T. Raine, A. Spinelli, J. Warusavitarne, A. Armuzzi, O. Bachmann, P. Bager, L. Biancone, B. Bokemeyer, P. Bossuyt, J. Burisch, P. Collins, G. Doherty, A. El‐Hussuna, P. Ellul, G. Fiorino, C. Frei-Lanter, F. Furfaro, C. Gingert, P. Gionchetti, J. Gisbert, F. Gomollón, Marien González Lorenzo, H. Gordon, T. Hlavatý, P. Juillerat, K. Katsanos, U. Kopylov, E. Krustiņš, T. Kucharzik, T. Lytras, C. Maaser, F. Magro, J. K. Marshall, P. Myrelid, Gianluca Pellino, I. Rosa, J. Sabino, E. Savarino, L. Stassen, J. Torres, Mathieu Uzzan, S. Vavricka, B. Verstockt, O. Zmora   +45 more
semanticscholar   +1 more source

KRAS and GNAS mutations in cell‐free DNA and in circulating epithelial cells in patients with intraductal papillary mucinous neoplasms—an observational pilot study

Molecular Oncology, EarlyView.
This study demonstrates that KRAS and GNAS mutations are more prevalent in patients with resected intraductal papillary mucinous neoplasms (IPMN) compared to those under clinical surveillance. GNAS mutations significantly differ between the two patient cohorts, indicating that their absence may serve as a potential biomarker to support conservative ...
Christine Nitschke, Marie Tölle, Philipp Walter, Kira Meißner, Mara Goetz, Jolanthe Kropidlowski, Andreas W. Berger, Jakob R. Izbicki, Felix Nickel, Thilo Hackert, Klaus Pantel, Harriet Wikman, Faik G. Uzunoglu   +12 more
wiley   +1 more source

MOG-specific CAR Tregs: a novel approach to treat multiple sclerosis

Journal of Neuroinflammation
Multiple sclerosis (MS) is an autoimmune disease affecting the central nervous system (CNS) with the immune system attacking myelin sheaths leading to neuronal death.
Jihane Frikeche, Marion David, Xavier Mouska, Damien Treguer, Yue Cui, Sandrine Rouquier, Enora Lecorgne, Emma Proics, Papa Babacar Fall, Audrey Lafon, Gregory Lara, Alexandra Menardi, David Fenard, Tobias Abel, Julie Gertner-Dardenne, Maurus de la Rosa, Celine Dumont   +16 more
doaj   +1 more source

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options. [PDF]

, 2020
Homeostasis of the lacrimal functional unit is needed to ensure a well-regulated ocular immune response comprising innate and adaptive phases. When the ocular immune system is excessively stimulated and/or immunoregulatory mechanisms are disrupted, the ...
Lin, Meng C, Neri, Piergiorgio, Perez, Victor L, Periman, Laura M, Saban, Daniel R   +4 more
core   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

HIV-1 gp41 Fusion Intermediate: A Target for HIV Therapeutics

Journal of the Formosan Medical Association, 2010
Human immunodeficiency virus (HIV)-1 infection is initiated by the binding of gp120 envelope glyco-protein to its cell receptor (CD4) and a coreceptor (CXCR4 or CCR5), followed by a series of conformational changes in the gp41 transmembrane subunit ...
Chungen Pan, Shuwen Liu, Shibo Jiang
doaj   +1 more source