Results 151 to 160 of about 1,429,081 (399)

Treatment patterns among patients with malignant pleural mesothelioma: An Italian, population‐based nationwide study

Thoracic Cancer, 2020
Background Malignant pleural mesothelioma (MPM) is a rare cancer with a poor prognosis. Centralization of rare cancer in dedicated centers is recommended to ensure expertise, multidisciplinarity and access to innovation.
Annalisa Trama, Claudia Proto, Diego Signorelli, Marina C. Garassino, Giuseppe Lo Russo, Monica Ganzinelli, Arsela Prelaj, Carolina Mensi, Manuela Gangemi, Valerio Gennaro, Elisabetta Chellini, Adele Caldarella, Italo F. Angelillo, Valeria Ascoli, Cristiana Pascucci, Giovanna Tagliabue, Rosanna Cusimano, Francesca Bella, Fabio Falcini, Enzo Merler, Giuseppe Masanotti, Antonio Ziino, Maria Michiara, Gemma Gola, Cinzia Storchi, Lucia Mangone, Maria F. Vitale, Claudia Cirilli, Rosario Tumino, Tiziana Scuderi, Anna C. Fanetti, Silvano Piffer, Marcello Tiseo, Gemma Gatta, Laura Botta, the LUME study WG   +35 more
doaj   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

The Risks of miRNA Therapeutics: In a Drug Target Perspective

Drug Design, Development and Therapy, 2021
Song Zhang, 1, 2 Zhujun Cheng, 3 Yanan Wang, 1 Tianyu Han 1 1Jiangxi Institute of Respiratory Disease, The First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China; 2College of Pharmaceutical Sciences ...
Zhang S, Cheng Z, Wang Y, Han T
doaj  

“VETERINARY PHARMACOLOGY AND THERAPEUTICS” [PDF]

, 1954

openalex   +1 more source

Pediatric Obesity: Influence on Drug Dosing and Therapeutics [PDF]

, 2018
Obesity is an ongoing global health concern and has only recently been recognized as a chronic disease of energy homeostasis and fuel partitioning. Obesity afflicts 17% of US children and adolescents.
Ameer, Barbara, PharmD, MBA, BCPS, FCP, Weintraub, Michael, MD   +1 more
core   +1 more source

Targeting rapid TKI‐induced AXL upregulation overcomes adaptive ERK reactivation and exerts antileukemic effects in FLT3/ITD acute myeloid leukemia

Molecular Oncology, EarlyView.
Adaptive ERK reactivation hinders FLT3 tyrosine kinase inhibitor (TKI) treatment in FLT3/ITD acute myeloid leukemia. Here, we report that FLT3 TKI treatment rapidly induces AXL expression and upregulation that is temporally associated with the adaptive ERK reactivation.
Tessa S. Seale, Li Li, J. Kyle Bruner, Melody Chou, Bao Nguyen, Jaesung Seo, Ruiqi Zhu, Mark J. Levis, Christine A. Pratilas, Donald Small   +9 more
wiley   +1 more source

Epigenetic mechanisms behind cellular sensitivity to DNA damage

Cell Stress, 2018
Epigenetic regulation of gene expression in cells is a complex and dynamic process that remains incompletely understood. The architecture of the chromatin itself and its level of condensation can greatly impact the expression of genes as well as the ...
Amanda K. Williamson, Zijing Zhu, Zhi-Min Yuan   +2 more
doaj   +1 more source

A Treatise on Therapeutics [PDF]

, 1880
David Lincoln
openalex   +1 more source

Screening polyoxometalates as aquaporin inhibitors for cancer therapeutics [PDF]

, 2019
Aquaporins (AQPs) are transmembrane protein channels that facilitate the diffusion of water and glycerol across cell membranes, crucial for water and energy homeostasis.
Aureliano, M., Coxixo, A. S., Pimpao, C., Rompel, A., Soveral, G.   +4 more
core  

Combined spatially resolved metabolomics and spatial transcriptomics reveal the mechanism of RACK1‐mediated fatty acid synthesis

Molecular Oncology, EarlyView.
The authors analyzed the spatial distributions of gene and metabolite profiles in cervical cancer through spatial transcriptomic and spatially resolved metabolomic techniques. Pivotal genes and metabolites within these cases were then identified and validated.
Lixiu Xu, Jinqiu Li, Junqi Ma, Ayshamgul Hasim   +3 more
wiley   +1 more source