Results 151 to 160 of about 872,419 (247)

Breaking the Stalemate: Advancing Sepsis Therapeutics Beyond Supportive Care. [PDF]

Public Health Rep
Strich JR, Teague HL, Yao X, Cruz RS, Childs RW.   +4 more
europepmc   +1 more source

5) Diagnosis and Therapeutics of Large Vessel Vasculitis

, 2020
Yoshikazu Nakaoka
openalex   +2 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

General Therapeutics of Gastric Affections

, 1908
MAURICE VÈJUX TYRODE
openalex   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Arimoclomol and levacetylleucine for the treatment of neurologic manifestations of Niemann-Pick disease type C: A therapeutics bulletin of the American College of Medical Genetics and Genomics (ACMG). [PDF]

Genet Med Open
Rodriguez-Gil JL, Smith WE, Chang IJ, Mendelsohn BA, ACMG Therapeutics Committee5∗documents@acmg.net.   +4 more
europepmc   +1 more source

From Yeast to Therapeutics: Modeling Neurodegenerative Diseases in Saccharomyces cerevisiae [PDF]

José Ribamar Ferreira-Júnior, Vittoria de Lima Camandona, Mário H. Barros   +2 more
openalex   +1 more source

Rational screening of peroxisome proliferator-activated receptor-γ agonists from natural products: potential therapeutics for heart failure [PDF]

, 2016
Rui Chen, Jing Wan, Jing Song, Qian Yan, Yong Liu, Shuiming Gu   +5 more
openalex   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

HCoVDB: a comprehensive database encompassing viral genomes, drug targets, and therapeutics of human coronaviruses [PDF]

Pan Zhang, Tianxiang Ouyang, Xiaowen Hu, Jie Huang, Bing Xiao, Zhijian Huang, Xuan Shi, Xinyi Wu, Linying Chen, Yongkang Wu, Hanyue Wang, Ying Zhang, Guangdi Li, Hui Liu, Lei Deng   +14 more
openalex   +1 more source