Results 11 to 20 of about 872,419 (247)

Monkeypox Virus: A Comprehensive Overview of Viral Pathology, Immune Response, and Antiviral Strategies

open access: yesVaccines, 2023
Background: The years 2022–2023 witnessed a monkeypox virus (mpox) outbreak in some countries worldwide, where it exists in an endemic form. However, the number of infectious cases is continuously on the rise, and there has been an unexpected, drastic ...
Shiza Malik   +4 more
doaj   +1 more source

Spider-Venom Peptides: Structure, Bioactivity, Strategy, and Research Applications

open access: yesMolecules, 2023
Spiders (Araneae), having thrived for over 300 million years, exhibit remarkable diversity, with 47,000 described species and an estimated 150,000 species in existence. Evolving with intricate venom, spiders are nature’s skilled predators.
Ruiyin Guo   +5 more
doaj   +1 more source

Expedition into Taurine Biology: Structural Insights and Therapeutic Perspective of Taurine in Neurodegenerative Diseases

open access: yesBiomolecules, 2020
Neurodegenerative diseases (NDs) are characterized by the accumulation of misfolded proteins. The hallmarks of protein aggregation in NDs proceed with impairment in the mitochondrial function, besides causing an enhancement in endoplasmic reticulum (ER ...
Mujtaba Aamir Bhat   +6 more
doaj   +1 more source

Novel Therapeutics: A Nemesis for Biofilm-forming Mycobacterium spp.

open access: yesJournal of Pure and Applied Microbiology, 2023
Tuberculosis (TB) is a contagious disease that is a significant cause of illness worldwide and has been declared one of the top ten causes of mortality across the world.
Niharika Pandey   +4 more
doaj   +1 more source

Interconnections between the Oral and Gut Microbiomes: Reversal of Microbial Dysbiosis and the Balance between Systemic Health and Disease

open access: yesMicroorganisms, 2021
The human microbiota represents a complex array of microbial species that influence the balance between the health and pathology of their surrounding environment.
Brandon Khor   +8 more
doaj   +1 more source

Navigating regulatory and analytical challenges in live biotherapeutic product development and manufacturing

open access: yesFrontiers in Microbiomes
The recent FDA approvals of Rebyota™ and Vowst™ represent landmark milestones within the burgeoning field of live microbiota-based products. Future microbiota-based treatment approaches also hold significant promise for treating patients with a myriad of
Microbiome Therapeutics Innovation Group   +1 more
doaj   +1 more source

Hypoxia-Driven Immune Escape in the Tumor Microenvironment

open access: yesCells, 2020
The tumor microenvironment is a complex ecosystem comprised of many different cell types, abnormal vasculature and immunosuppressive cytokines. The irregular growth kinetics with which tumors grow leads to increased oxygen consumption and, in turn ...
Alyssa Vito   +2 more
doaj   +1 more source

Origin, Potential Therapeutic Targets and Treatment for Coronavirus Disease (COVID-19)

open access: yesPathogens, 2020
The ongoing episode of coronavirus disease 19 (COVID-19) has imposed a serious threat to global health and the world economy. The disease has rapidly acquired a pandemic status affecting almost all populated areas of the planet.
Muhammad Shahid Nadeem   +6 more
doaj   +1 more source

Dengue, West Nile, and Zika Viruses: Potential Novel Antiviral Biologics Drugs Currently at Discovery and Preclinical Development Stages

open access: yesPharmaceutics, 2022
Dengue, West Nile and Zika viruses are vector-borne flaviviruses responsible for numerous disease outbreaks in both Hemispheres. Despite relatively low mortality, infection may lead to potentially severe situations such as (depending on the virus ...
Ivo C. Martins   +2 more
doaj   +1 more source

Exploring the potential of transethosomes in therapeutic delivery: A comprehensive review

open access: yesMedComm – Biomaterials and Applications, 2023
The growing need for innovative drug delivery systems has led to extensive research to address the limitations associated with conventional dosage forms.
Pavani Chowdary   +2 more
doaj   +1 more source

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