Results 11 to 20 of about 1,594,004 (375)
Effectiveness of Acceptance and Commitment Therapy in Reducing High-risk and Harmful Behaviors in Students [PDF]
مجله علوم پزشکی صدرا, 2023 Introduction: The prevalence of high-risk behaviors in young people is one of the concerns of societies. This study aimed to evaluate the effectiveness of Acceptance and Commitment therapy in reducing high-risk and harmful behaviors among high school ...
Zahra Alizadeh, Abbas Rohani
doaj +1 more source
Noncoding RNA therapeutics — challenges and potential solutions
Nature reviews. Drug discovery, 2021 Therapeutic targeting of noncoding RNAs (ncRNAs), such as microRNAs (miRNAs) and long noncoding RNAs (lncRNAs), represents an attractive approach for the treatment of cancers, as well as many other diseases.
Melanie Winkle +3 more
semanticscholar +1 more source
Therapeutic effects of diosgenin on alveolar bone loss and apoptosis in diabetic rats with experimental periodontitis [PDF]
Iranian Journal of Basic Medical Sciences, 2023 Objective(s): The present study aims to evaluate the efficacy of administered diosgenin (DG) which has anti-oxidant and anti-inflammatory effects, on alveolar bone loss (ABL) and apoptosis in diabetic rats with periodontitis. Materials and Methods: Forty
Alper Kızıldağ +4 more
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Engineering cytokine therapeutics
Nature Reviews Bioengineering, 2023 Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety of immune-related disorders. However, the widespread clinical use of cytokines has been limited by their short blood half-lives and severe side effects caused ...
Jeroen Deckers +15 more
semanticscholar +1 more source
Engineering siRNA therapeutics: challenges and strategies
Journal of Nanobiotechnology, 2023 Small interfering RNA (siRNA) is a potential method of gene silencing to target specific genes. Although the U.S. Food and Drug Administration (FDA) has approved multiple siRNA-based therapeutics, many biological barriers limit their use for treating ...
Syed Saqib Ali Zaidi +5 more
semanticscholar +1 more source
Oncogenesis, 2023 Chimeric antigen receptor T-cell (CAR-T) therapy has demonstrated potent clinical efficacy in the treatment of hematopoietic malignancies. However, the application of CAR-T in solid tumors has been limited due in part to the expression of inhibitory ...
Zhao Chen +25 more
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A spoonful of sugar: the application of glycopolymers in therapeutics [PDF]
, 2011 Glycopolymers, synthetic polymers displaying carbohydrate moieties, have been linked to many potential applications at the biology–chemistry interface. One area that holds particular promise is the employment of glycopolymers as vehicles for therapeutics
Cameron, Neil R., Spain, Sebastian G.
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PEGylated therapeutics in the clinic
Bioengineering & Translational Medicine, 2023 The covalent attachment of polyethylene glycol (PEG) to therapeutic agents, termed PEGylation, is a well‐established and clinically proven drug delivery approach to improve the pharmacokinetics and pharmacodynamics of drugs.
Yongsheng Gao +3 more
semanticscholar +1 more source
Journal of Neuroinflammation, 2021 Background Inflammation in the central nervous system (CNS) is observed in many neurological disorders. Nitric oxide-soluble guanylate cyclase-cyclic guanosine monophosphate (NO–sGC–cGMP) signaling plays an essential role in modulating neuroinflammation.
Susana S. Correia +16 more
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Pregabalin: a range of misuse-related unanswered questions [PDF]
, 2019 © 2019 The Authors.
Chiappini, Stephania, Schifano, Fabrizio
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