Results 61 to 70 of about 1,412,582 (334)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

WRN inhibition leads to its chromatin-associated degradation via the PIAS4-RNF4-p97/VCP axis

Nature Communications
Synthetic lethality provides an attractive strategy for developing targeted cancer therapies. For example, cancer cells with high levels of microsatellite instability (MSI-H) are dependent on the Werner (WRN) helicase for survival.
Fernando Rodríguez Pérez, Dean Natwick, Lauren Schiff, David McSwiggen, Alec Heckert, Melina Huey, Huntly Morrison, Mandy Loo, Rafael G. Miranda, John Filbin, Jose Ortega, Kayla Van Buren, Danny Murnock, Arnold Tao, Renee Butler, Kylie Cheng, William Tarvestad, Zhengjian Zhang, Eric Gonzalez, Rand M. Miller, Marcus Kelly, Yangzhong Tang, Jaclyn Ho, Daniel Anderson, Charlene Bashore, Stephen Basham   +25 more
doaj   +1 more source

Epidemiology and practice patterns for male breast cancer compared with female breast cancer in Japan

Cancer Medicine, 2020
Background The incidence of male breast cancer (MBC), although rare, has shown an increase. However, the current epidemiology of and practice patterns for MBC remain unclear.
Taisuke Ishii, Eriko Nakano, Tomone Watanabe, Takahiro Higashi   +3 more
doaj   +1 more source

Exploring Virulence Factors and Alternative Therapies against Staphylococcus aureus Pneumonia

Toxins, 2020
Pneumonia is an acute pulmonary infection associated with high mortality and an immense financial burden on healthcare systems. Staphylococcus aureus is an opportunistic pathogen capable of inducing S.
Jelle Vlaeminck, Dina Raafat, Kristin Surmann, Leen Timbermont, Nicole Normann, Bret Sellman, Willem J. B. van Wamel, Surbhi Malhotra-Kumar   +7 more
doaj   +1 more source

Impact of tumor-specific targeting on the biodistribution and efficacy of siRNA nanoparticles measured by multimodality in vivo imaging [PDF]

, 2007
Targeted delivery represents a promising approach for the development of safer and more effective therapeutics for oncology applications. Although macromolecules accumulate nonspecifically in tumors through the enhanced permeability and retention (EPR ...
Bartlett, Derek W., Davis, Mark E., Hildebrandt, Isabel J., Su, Helen, Weber, Wolfgang A.   +4 more
core   +2 more sources

CCT4 promotes tunneling nanotube formation

FEBS Letters, EarlyView.
Tunneling nanotubes (TNTs) are membranous tunnel‐like structures that transport molecules and organelles between cells. They vary in thickness, and thick nanotubes often contain microtubules in addition to actin fibers. We found that cells expressing monomeric CCT4 generate many thick TNTs with tubulin.
Miyu Enomoto, Akiko Asada, Taro Saito, Kanae Ando   +3 more
wiley   +1 more source

Characterization of exoribonuclease XRN1 as a cancer target and identification of adenosine-3’,5’-bisphosphate as a potent enzyme inhibitor

Communications Biology
XRN1 (5’-3’ exoribonuclease 1) degrades RNA from the 5′ → 3′ direction and utilizes both single- and double-stranded RNA as substrates. XRN1 plays a critical role in mRNA turnover as well as regulating the cellular response to viral infection.
Gordon J. Lockbaum, Maureen M. Lynes, Sophie A. Shen, Julie Liu, Nicholas Holt, Sunaina P. Nayak, Kevin E. Knockenhauer, Shihua Yao, E. Allen Sickmier, Anugraha Raman, Jie Wu, April Case, Livia Shehaj, Shane M. Buker, Simina Grigoriu, Scott Ribich, Stephen J. Blakemore, Brian A. Sparling, Kenneth W. Duncan, Robert A. Copeland, Serena J. Silver, P. Ann Boriack-Sjodin   +21 more
doaj   +1 more source

Therapeutic Strategies to Target Calcium Dysregulation in Alzheimer’s Disease

Cells, 2020
Alzheimer’s disease (AD) is the most common form of dementia, affecting millions of people worldwide. Unfortunately, none of the current treatments are effective at improving cognitive function in AD patients and, therefore, there is an urgent need for ...
Maria Calvo-Rodriguez, Elizabeth K. Kharitonova, Brian J. Bacskai   +2 more
doaj   +1 more source

RNAi-Based Therapy: Combating Shrimp Viral Diseases

Viruses, 2023
Shrimp aquaculture has become a vital industry, meeting the growing global demand for seafood. Shrimp viral diseases have posed significant challenges to the aquaculture industry, causing major economic losses worldwide.
Md. Shahanoor Alam, Mohammad Nazrul Islam, Mousumi Das, Sk. Farzana Islam, Md. Golam Rabbane, Ehsanul Karim, Animesh Roy, Mohammad Shafiqul Alam, Raju Ahmed, Abu Syed Md. Kibria   +9 more
doaj   +1 more source

The Immunological Basis of Dry Eye Disease and Current Topical Treatment Options. [PDF]

, 2020
Homeostasis of the lacrimal functional unit is needed to ensure a well-regulated ocular immune response comprising innate and adaptive phases. When the ocular immune system is excessively stimulated and/or immunoregulatory mechanisms are disrupted, the ...
Lin, Meng C, Neri, Piergiorgio, Perez, Victor L, Periman, Laura M, Saban, Daniel R   +4 more
core   +1 more source