Results 111 to 120 of about 5,534,048 (331)

Development of learning objectives for neurology in a veterinary curriculum: Part II: Postgraduates [PDF]

, 2015
Background: Specialization in veterinary medicine in Europe is organized through the Colleges of the European Board of Veterinary Specialization. To inform updating of the curriculum for residents of the European College of Veterinary Neurology (ECVN ...
Anderson, T J, Añor, S, Barcelona, CEU Cardinal Herrera University, Ehlers, J P, Glasgow, Hannover School Vet Med, Lin, Y W, Lujan-Feliu-Pascual, A, Penderis, J, Stein, V M, Tipold, A, University Witten-Herdecke, Volk, H A   +13 more
core   +6 more sources

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Diare Disebabkan Infeksi Escherichia coli pada Anjing

Jurnal Ilmu Peternakan dan Veteriner Tropis, 2019
Diarrhea is a symptom of a disease that often occurs in dogs, but the diagnosis and therapy usually only based on clinical symptoms. The purpose of this case report is to examine, diagnose and treat a dog with diarrhea. The material of this report is a 4
Risang Aji Dewandaru, Soedarmanto Indarjulianto, Yanuartono Yanuartono, Alfarisa Nururrozi, Hary Purnamaningsih, Rusmi Hayati   +5 more
doaj   +3 more sources

Features and prognostic impact of distant metastases in 45 dogs with de novo stage IV cutaneous mast cell tumours: A prospective study [PDF]

, 2017
BACKGROUND: Distant metastases in dogs with cutaneous mast cell tumors (cMCT) are rare and incurable. The aims of this prospective study were to clarify the clinico-pathological features of stage IV cMCTs and to identify possible prognostic factors for ...
Amati, M., Dacasto, M., Dentini, A., Ferrari, R., Giantin, M., Laganga, P., Marconato, L., Pizzoni, S., Sabattini, S., Stefanello, D., Tortorella, G.   +10 more
core   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Composite lymphoma of concurrent T zone lymphoma and large cell B cell lymphoma in a dog. [PDF]

, 2019
BackgroundEvolution of indolent to aggressive lymphoma has been described in dogs but is difficult to distinguish from the de novo development of a second, clonally distinct lymphoma.
Bienzle, Dorothee, Darzentas, Nikos, Deravi, Nariman, Hwang, Mei-Hua, Keller, Stefan M, Matsuyama, Arata, Richardson, Danielle   +6 more
core   +1 more source

Avenues of future research in homotransplantation of the liver with particular reference to hepatic supportive procedures, antilymphocyte serum, and tissue typing [PDF]

, 1966
Three general areas of research which bear on the developing field of liver transplantation are reviewed. These are: (1) the prospects of obtaining better immunosuppression with particular reference to heterologous antilymphocyte serum; (2) the possible ...
Anderson, Bibler, Eiseman, Gray, Halgrimson, Hill, Jeejeebhoy, Marchioro, Mikaeloff, Monaco, Monaco, Norman, Patrick, Rich, Robert J. McCardle, Sacks, Starzl, Starzl, Starzl, Starzl, Steinberg, Tanous D. Faris, Thaler, Thomas E. Starzl, Thomas L. Marchioro, Vang, Waksman, Woodruff, Woodruff, Woodruff, Woodruff, Yoji Iwaski   +31 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Clinical Trials of Immunogene Therapy for Spontaneous Tumors in Companion Animals [PDF]

, 2014
Despite the important progress obtained in the treatment of some pets’ malignancies, new treatments need to be developed. Being critical in cancer control and progression, the immune system’s appropriate modulation may provide effective therapeutic ...
Finocchiaro, Liliana Maria Elena, Glikin, Gerardo Claudio   +1 more
core   +4 more sources