Results 51 to 60 of about 143,501 (306)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Ablation Mechanism of AlSiB-C/C Composites under an Oxy-Acetylene Torch

Metals, 2023
In order to improve the ablation resistance of C/C composites, an AlSiB alloy (mass ratio of Al/Si/B = 2:4:1) was used as a dissipative agent to fill the pores of a C/C composites matrix by reactive melt infiltration to prepare AlSiB-C/C composites.
Qiuchen Han, Lei Chang, Zhaoqun Sun, Jiaqi Sun, Zengyan Wei, Pingping Wang, Ziyang Xiu, Huasong Gou, Pengchao Kang, Gaohui Wu   +9 more
doaj   +1 more source

Spectral imaging of thermal damage induced during microwave ablation in the liver [PDF]

, 2018
Induction of thermal damage to tissue through delivery of microwave energy is frequently applied in surgery to destroy diseased tissue such as cancer cells.
Clancy, Neil T., Clarkson, Matthew J., Davidson, Brian, Gurusamy, Kurinchi, Hawkes, David J., Jones, Geoffrey, Stoyanov, Danail   +6 more
core   +2 more sources

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Representing moisture fluxes and phase changes in glacier debris cover using a reservoir approach [PDF]

, 2014
Due to the complexity of treating moisture in supraglacial debris, surface energy balance models to date have neglected moisture infiltration and phase changes in the debris layer.
Brock, Benjamin, Bush, Andrew, Collier, Emily, Essery, Richard, Maussion, Fabien, Nicholson, Lindsey   +5 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Advances and Challenges of Local Thermal Ablation in Non-small Cell Lung Cancer

Chinese Journal of Lung Cancer, 2020
Non-small cell lung cancer (NSCLC) is the most common pathological type of primary lung cancer. Currently, main treatment approaches for NSCLC patients include surgical resection, radiotherapy, chemotherapy, targeted therapy and so on.
Qing GOU, Zejian ZHOU, Mingfang ZHAO, Xiaoming CHEN, Qing ZHOU   +4 more
doaj   +1 more source

Radiofrequency ablation for liver tumors abutting complex blood vessel structures: treatment protocol optimization using response surface method and computer modeling

International Journal of Hyperthermia, 2022
Objective To achieve a result of a large tumor ablation volume with minimal thermal damage to the surrounding blood vessels by designing a few clinically-adjustable operating parameters in radiofrequency ablation (RFA) for liver tumors abutting complex ...
Zheng Fang, Hongjun Wei, Hanwei Zhang, Michael A. J. Moser, Wenjun Zhang, Zhiqin Qian, Bing Zhang   +6 more
doaj   +1 more source

Thermal Ablation of Lung Tumors: Focus on Microwave Ablation [PDF]

RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren, 2017
Background Image-guided thermal ablation can be used for the treatment of medically inoperable primary and metastatic lung cancer. These techniques are based on the heating up or freezing (cryoablation) of a volume of tissue around a percutaneous applicator that induces necrosis of the tumor.
Thomas J, Vogl, Nour-Eldin A, Nour-Eldin, Moritz Hans, Albrecht, Benjamin, Kaltenbach, Wolfgang, Hohenforst-Schmidt, Han, Lin, Bita, Panahi, Kathrin, Eichler, Tatjana, Gruber-Rouh, Andrei, Roman   +9 more
openaire   +2 more sources