Results 81 to 90 of about 56,841 (268)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Effective thermal conductivity and thermochemical ablation behavior analysis of 4D braided C/C composites at elevated temperatures

Case Studies in Thermal Engineering
Considering the anisotropic heat conduction and temperature-dependent thermal conductivity is of great significance for the ablation behavior of carbon/carbon (C/C) composites.
Kexin Wang, Jing Yang, Xiaobo Guo, Xicheng Guo, Jingran Ge, Jun Liang   +5 more
doaj   +1 more source

Similar complication rates for irreversible electroporation and thermal ablation in patients with hepatocellular tumors

Radiology and Oncology, 2019
To compare the frequency of adverse events of thermal microwave (MWA) and radiofrequency ablation (RFA) with non-thermal irreversible electroporation (IRE) in percutaneous ablation of hepatocellular carcinoma (HCC).
Verloh Niklas, Jensch Isabel, Lürken Lukas, Haimerl Michael, Dollinger Marco, Renner Philipp, Wiggermann Philipp, Werner Jens Martin, Zeman Florian, Stroszczynski Christian, Beyer Lukas Philipp   +10 more
doaj   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Research progress in ablative resistant ethylene■propylene■diene terpolymer

Hecheng xiangjiao gongye
Ethylene■propylene■diene terpolymer （EPDM） was a new type of ablation■resistant matrix material with low density, good thermal stability and excellent ablation resistance, and it found extensive applications in aerospace, thermal protection and other ...
ZHAO Dong-wei1, WEN Yan-wei2, FU Quan-sheng1, CHEN Meng-han1, YANG Zi-fan1, JIA Hong-bing1
doaj   +1 more source

The current status of thermal ablation in the management of T1b renal masses

International Journal of Hyperthermia, 2019
The role of thermal ablation in the management of T1b renal masses is not well defined. The purpose of this review is to examine current evidence for cryoablation, radiofrequency ablation, and microwave ablation of T1b renal masses as well as review ...
BT Welch, PH Shah, RH Thompson, TD Atwell   +3 more
doaj   +1 more source

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

Complications after thermal ablation for thyroid nodules across countries

Frontiers in Endocrinology
ObjectiveThermal ablation is an effective treatment for thyroid nodules; however, the range of complications associated with thermal ablation is unclear.
Shuang Wu, Yantao Cai, Xiaoyu Liu, Chenfang Zhu   +3 more
doaj   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source