Results 41 to 50 of about 25,353,476 (264)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Thermal decomposition of metatorbernite - A controlled rate thermal analysis study [PDF]
, 2005 The mineral metatorbernite, Cu[(UO2)2(PO4)]2•8H2O, has been studied using a combination of energy dispersive X-ray analysis, X-ray diffraction, dynamic and controlled rate thermal analysis techniques. X-ray diffraction shows that the starting material in
Weier, Matt L. +5 more
core +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Thermal analysis of high explosives: liquid state decomposition of RDX [PDF]
, 2000 journal articleNonisothermal thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) have been applied to the thermal decomposition of RDX.
Wight, Charles Albert +1 more
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Studie termického rozkladu a vyhodnocení rizikových vlastností směsí jodistan/palivo
, 2019 The thermal decomposition of iodine periodate and its mixture with lactose was investigated using differential thermal analysis (DTA, open system), cell-differential calorimetry (SC-DSC) and IR and Raman spectroscopy.Tepelný rozklad jodistanu draselného ...
Jalový, Zdeněk +4 more
core +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Heterogeneous bulk nucleation and differential thermal analysis
, 1981 The effect of the addition of Ag2O on the mechanism of non-isothermal devitrification of Li2O · 2 SiO2 glass has been studied by differential thermal analysis.
A. Marotta +3 more
core +1 more source
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source
Thermal stress analysis of fuel element in particle bed reactor [PDF]
, 2013 In this paper, a method of determination of temperature and thermal stress distributions in a fuel element of a new gas-cooled, thermal spectrum particle bed reactor (GCT-PBR) was derived.
Han, Lu
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