Results 61 to 70 of about 25,353,476 (264)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Batch Sintering of FeO·OH and Fe₂O₃ Blends: Chemical and Metallurgical Characterization

Metals
A sample of goethite iron ore sinter feed (G_SF) was employed as a raw material in a sintering bed. This sample partially replaced hematite sinter feed (H_SF), which is currently used as raw material in a sintering plant in the state of Minas Gerais ...
Igor J. U. V. Pereira, Henrique C. S. Coelho, Cláudio G. Santos, Eduardo A. Brocchi, Rodrigo F. M. Souza, Victor A. A. Oliveira   +5 more
doaj   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

The use of thermal analysis methods for monitoring the development of bitumen reservoirs using thermal recovery technologies

, 2020
© 2017 Akadémiai Kiadó, Budapest, Hungary The products obtained from production wells of Ashalchinsk and Mordovo-Karmalsk bitumen fields of the Republic of Tatarstan (Russia) using thermal recovery technologies as well as the core materials recovered ...
Ganeeva Y., Romanov G., Okhotnikova E., Yusupova T.   +3 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Prediction of incompatible reaction of dibenzoyl peroxide by isothermal calorimetry analysis and green thermal analysis technology

, 2012
[[abstract]]Dibenzoyl peroxide (BPO) has been widely employed in the petrifaction industry. This study determined the unsafe characteristics of organic peroxide mixed with incompatible materials so as to help prevent runaway reactions, fires or ...
林駿憑;Lin, Chun-Ping;Tseng, Jo-Ming
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Thermal and exergetic analysis of Metal Foam-enhanced Cascaded Thermal Energy Storage (MF-CTES) [PDF]

, 2013
Metal Foam-enhanced Cascaded Thermal Energy Storage (MF-CTES) has been proposed to solve the problem of poor heat transfer during heat exchange process, which is caused by unavoidable decrease of temperature differences. This paper conducts a theoretical
Zhao, Changying, Tian, Yuan, Tian, Y. (Yuan), Zhao, C.Y.   +3 more
core   +1 more source

Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila

Communications Biology
Sensory inputs of temperature dynamics in the environment are essential for appropriate physiological outputs. The responsiveness of sensory neurons is maintained by functional thermosensor expression.
Xiangmei Deng, Takuto Suito, Makoto Tominaga, Takaaki Sokabe   +3 more
doaj   +1 more source