Results 61 to 70 of about 1,137,079 (315)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Monoacylglycerol acyltransferase maintains ionotropic receptor expression for cool temperature sensing and avoidance in Drosophila

Communications Biology
Sensory inputs of temperature dynamics in the environment are essential for appropriate physiological outputs. The responsiveness of sensory neurons is maintained by functional thermosensor expression.
Xiangmei Deng, Takuto Suito, Makoto Tominaga, Takaaki Sokabe   +3 more
doaj   +1 more source

Prediction of incompatible reaction of dibenzoyl peroxide by isothermal calorimetry analysis and green thermal analysis technology

, 2012
[[abstract]]Dibenzoyl peroxide (BPO) has been widely employed in the petrifaction industry. This study determined the unsafe characteristics of organic peroxide mixed with incompatible materials so as to help prevent runaway reactions, fires or ...
林駿憑;Lin, Chun-Ping;Tseng, Jo-Ming
core  

A new baseline for the Newtonian thermal analysis of casting: two-capacitive system baseline Modeling the effects of the thermal capacity of mold

, 2015
Computer-aided cooling curve thermal analysis for the casting process is usually applied to predict the latent heat of transformation and the solid fraction.
Erbas, Kadir Can
core   +1 more source

Pile heat exchangers: thermal behaviour and interactions [PDF]

, 2013
Thermal piles – that is structural foundation piles also used as heat exchangers as part of a ground energy system – are increasingly being adopted for their contribution to more sustainable energy strategies for new buildings.
Loveridge, F.A., Powrie, W., Powrie, W, Loveridge, F   +3 more
core   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Measuring labor productivity dynamics in U.S. industrial and electric power sectors: a case study (2014–2023)

Frontiers in Energy Research
This study proposes a subsystem methodology for measuring labor productivity in the U.S. industrial and electric power sectors by leveraging public data available between 2014 and 2023.
Nahuel Guaita, Silvio Guaita, Mauricio Tano, Eliezer A. Reyes Molina   +3 more
doaj   +1 more source

The use of thermal analysis methods for monitoring the development of bitumen reservoirs using thermal recovery technologies

, 2020
© 2017 Akadémiai Kiadó, Budapest, Hungary The products obtained from production wells of Ashalchinsk and Mordovo-Karmalsk bitumen fields of the Republic of Tatarstan (Russia) using thermal recovery technologies as well as the core materials recovered ...
Ganeeva Y., Romanov G., Okhotnikova E., Yusupova T.   +3 more
core