Results 71 to 80 of about 24,209,160 (311)

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Measurements of ionic liquids thermal conductivity and thermal diffusivity [PDF]

, 2016
Thermal conductivity and thermal diffusivity of ionic liquids (ILs) are investigated in this work. A hot disk method for ILs thermal conductivity and thermal diffusivity measurement is utilized.
Yansong Zhao, Yingpeng Zhen, Zhao, Yansong, Boström, Tobias, Tobias Boström, Zhen, Yingpeng, Jelle, Bjørn Petter, Bjørn Petter Jelle   +7 more
core   +1 more source

A Model of a Diaphragm Wall Ground Heat Exchanger [PDF]

, 2020
Ground thermal energy is a sustainable source that can substantially reduce our dependency on conventional fuels for heating and cooling of buildings.
Rees, S, Carbayo, MP, Mardaras, IU, Polo Carbayo, Merche, Shafagh, I, Marina Curto Janó, Shafagh, Ida, Iñigo Urra Mardaras, Ida Shafagh, Rees, Simon, Merche Polo Carbayo, Simon Rees, Janó, MC, Urra Mardaras, Iñigo, Curto Janó, Marina   +14 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Batch Sintering of FeO·OH and Fe₂O₃ Blends: Chemical and Metallurgical Characterization

Metals
A sample of goethite iron ore sinter feed (G_SF) was employed as a raw material in a sintering bed. This sample partially replaced hematite sinter feed (H_SF), which is currently used as raw material in a sintering plant in the state of Minas Gerais ...
Igor J. U. V. Pereira, Henrique C. S. Coelho, Cláudio G. Santos, Eduardo A. Brocchi, Rodrigo F. M. Souza, Victor A. A. Oliveira   +5 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The use of thermal analysis methods for monitoring the development of bitumen reservoirs using thermal recovery technologies

, 2020
© 2017 Akadémiai Kiadó, Budapest, Hungary The products obtained from production wells of Ashalchinsk and Mordovo-Karmalsk bitumen fields of the Republic of Tatarstan (Russia) using thermal recovery technologies as well as the core materials recovered ...
Ganeeva Y., Romanov G., Okhotnikova E., Yusupova T.   +3 more
core  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Thermal decomposition of metatorbernite - A controlled rate thermal analysis study [PDF]

, 2005
The mineral metatorbernite, Cu[(UO2)2(PO4)]2•8H2O, has been studied using a combination of energy dispersive X-ray analysis, X-ray diffraction, dynamic and controlled rate thermal analysis techniques. X-ray diffraction shows that the starting material in
Weier, Matt L., Martens, Wayde N., Kristof, Janos, Horvath, Erzsebet, Frost, Ray L.   +4 more
core   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source