Results 71 to 80 of about 25,353,476 (264)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

The influence of crucible material on the DSC thermal analysis compared to freeze-drying microscopy results

, 2009
The aim of this study was to investigate the influence of different crucible materials on the thermal analysis of binary systems. The thermal properties of two distinct solutions were measured both by Differential Scanning Calorimetry (DSC) and freeze ...
PITOMBO, Ronaldo Nogueira de Moraes, Virgilio Tattini, Duclerc Parra, Ronaldo de Moraes Pitombo, PARRA, Duclerc Fernandes, TATTINI JR., Virgilio   +5 more
core   +1 more source

Thermal analysis of induction and synchronous reluctance motors [PDF]

, 2005
In this paper, the thermal behavior of two induction motors (2.2 and 4 kW, four poles) and two synchronous reluctance motors [(SynRMs) transverse-laminated] are investigated and compared.
Staton, D., Pastorelli, Michele Angelo, A. Boglietti, D. Staton, A. Cavagnino, A. Vagati, Boglietti, Aldo, Vagati, Alfredo, Cavagnino, Andrea, STATON D., M. Pastorelli   +10 more
core   +1 more source

Measuring labor productivity dynamics in U.S. industrial and electric power sectors: a case study (2014–2023)

Frontiers in Energy Research
This study proposes a subsystem methodology for measuring labor productivity in the U.S. industrial and electric power sectors by leveraging public data available between 2014 and 2023.
Nahuel Guaita, Silvio Guaita, Mauricio Tano, Eliezer A. Reyes Molina   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Room-temperature FeSi2-doped Cu2Se thermoelectric films with enhanced figure of merit

Scientific Reports
Thermoelectric (TE) materials offer a promising pathway toward achieving carbon neutrality by converting waste heat into electricity. The enhancement of their figure-of-merit (zT) depends on optimizing the composition of materials and nanostructures ...
Masahiro Goto, Michiko Sasaki, Taku Moronaga, Toru Hara, Yibin Xu   +4 more
doaj   +1 more source

Microtwinning avalanches induced the Protevin–Le Châtelier effect in PWA1483 at 750 °C

Materials Research Letters
The flow behavior and deformation mechanisms of the [001]-oriented single-crystal nickel-based superalloy PWA1483 are investigated under quasi-static compressive and tensile loading conditions at 750°C.
Jiao Li, Peng Zhang, Jiaming Bai, Peng Liu, Yong Yuan, Xiaolong Song, Yuefeng Gu   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A kinetic analysis of thermal decomposition of polyaniline and its composites with rare earth oxides

, 2015
The decomposition kinetics of the pure polyaniline (PANI), PANI/CeO2 composites, and PANI/Dy2O3 composites were investigated using thermogravimetry (TG) technique under air atmosphere.
Tan, Zhicheng, Huang, Zihang, Wang, Shaoxu, Li, Yini, Zhang, Shihui   +4 more
core   +1 more source

Application of thermal analysis to material science

, 2022
S.455-465Thermoanalytical methods are used for investigation of outgassing and sintering of hardmetals. Shrinkage (DILA), mass loss (TG), gas evolution (EGA - mass spectrometry) and thermal effects (DSC) allow to describe sintering processes. The results
Leitner, G.
core   +1 more source