Results 41 to 50 of about 203,544 (317)

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

Calculation and analysis of heat generation of aero-engine bearing-support system

Hangkong gongcheng jinzhan
The heat source analysis and quantitative calculation of heat production of the bearing-support structure system can provide a reliable basis for the thermal protection design of the bearing cavity.
SUN Peng, MU Qinqin, CHEN Yonghui, YAN Qun   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Calculation of a lower bound ratchet limit part 1 – Theory, numerical implementation and verification

, 2013
It is important to be able to calculate the ratchet limit of a component when performing integrity assessments of plant components. This paper details the addition of a lower bound ratchet limit calculation to the Linear Matching Method. The extension of
Tipping, David, Ure, James Michael, Chen, Haofeng   +2 more
core   +1 more source

Solving the More Difficult Aspects of Electric Motor Thermal Analysis in Small and Medium Size Industrial Induction Motors [PDF]

, 2005
With the ever-increasing pressure on electric motor manufacturers to develop smaller and more efficient electric motors, there is a need for more thermal analysis in parallel with the traditional electromagnetic design.
Staton, D., D. STATON, Boglietti, Aldo, Cavagnino, Andrea   +3 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Evolution and Modern Approaches for Thermal Analysis of Electrical Machines [PDF]

, 2009
In this paper, the authors present an extended survey on the evolution and the modern approaches in the thermal analysis of electrical machines. The improvements and the new techniques proposed in the last decade are analyzed in depth and compared in ...
Shanel, M., D. STATON, M. SHANEL, Aldo Boglietti, Andrea Cavagnino, C. MEJUTO, Carlos Mejuto, David Staton, M. MUELLER, Mueller, M., Staton, D., Mejuto, C., Martin Shanel, Boglietti, Aldo, Cavagnino, Andrea, Markus Mueller   +15 more
core   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source