Results 61 to 70 of about 305,392 (312)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Thermal Degradation and Microstructural Evolution of Geopolymer-Based UHPC with Silica Fume and Quartz Powder

Infrastructures
The durability and fire resilience of concrete structures are increasingly critical in modern construction, particularly under elevated-temperature exposure. With this context, the current study explores the thermal and microstructural characteristics of
Raghda A. Elhefny, Mohamed Abdellatief, Walid E. Elemam, Ahmed M. Tahwia   +3 more
doaj   +1 more source

Photo and thermal degradation of Glyphosate and Fluazifop-butyl herbicides with and without additives

مجلة المختار للعلوم, 2017
The study investigated the effect of some additives on glyphosate and fluazifop-butyl herbicides light-decomposition by ultraviolet rays and temperature were studied under laboratory conditions.
Mohammed. A. Balah , Abdel-Rahman Gamal Aldin , Zidane. H. Zidan, Sayed. A. Dahroug   +3 more
doaj   +1 more source

Thermal degradation, antioxidant and antimicrobial activity of the synthesized allicin and allicin incorporated in gel [PDF]

Hemijska Industrija, 2010
The main carriers of the pharmacological activity of garlic (Allium sativum L.) are organic sulfur compounds, the most important among them being allicin, a sulfenic acid thioester, or allylthiosulfonate.
Ilić Dušica P., Nikolić Vesna D., Nikolić Ljubiša B., Stanković Mihajlo Z., Stanojević Ljiljana P.   +4 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

THERMAL-DEGRADATION OF BLENDS OF PVC WITH POLY(ETHYLENE ADIPATE) [PDF]

, 1993
The thermal degradation of PVC-PEAD blends has been studied over the whole composition range, using thermal volatilisation analysis and thermogravimetry.
BASAN, S, MCNEILL, IC
core   +1 more source

Mechanical Properties and Degradation Mechanism of SiC Fibers Exposed to Oxidative Environment up to 1600 °C

Applied Sciences
In order to investigate the microstructure evolution and the degradation mechanism of SiC fiber in a high-temperature oxidative environment, the SiC fiber was thermally exposed at temperature up to 1600 °C in air.
Kailin Huang, Beibei Ma, Jixiang Dai, Jianjun Sha   +3 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A spectroscopic study of the degradation of polyurethane coil coatings. [PDF]

, 2012
PhDThe degradation of polyurethane (PU) coil coatings were studied with step scan phase modulation photo-acoustic (SS-PM-PA) FTIR, confocal Raman mapping (CRM) and scanning electron microscopy (SEM). PU coatings were oven cured for 30 seconds to reach
Zhang, Ying
core  

Investigating the Thermal Stability of Omega Fatty Acid-Enriched Vegetable Oils

Foods
This study investigates the thermal stability of omega fatty acid-enriched vegetable oils, focusing on their behavior under high-temperature conditions commonly encountered during frying.
Katalin Nagy, Bogdan-Cezar Iacob, Ede Bodoki, Radu Oprean   +3 more
doaj   +1 more source