Results 41 to 50 of about 10,342,891 (309)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Reactivity and performance of steam gasification during biomass batch feeding

Carbon Resources Conversion, 2023
The steam gasification characteristics of poplar sawdust were investigated in a piston fed fixed-bed gasifier, reflecting the batch feeding process of fixed-bed gasifiers in industrial applications.
Yuna Ma, Zefeng Ge, Mingxun Zeng, Zhenting Zha, Yujie Tao, Huiyan Zhang   +5 more
doaj   +1 more source

Critical review of standards for indoor thermal environment and air quality

, 2020
Quality of the indoor environment has become an important parameter to account for in new and existing buildings due to the increasing number of people spending most of their time indoors.
D. Khovalyg, O. B. Kazanci, H. Halvorsen, Ida Gundlach, W. Bahnfleth, J. Toftum, B. Olesen   +6 more
semanticscholar   +1 more source

Thermal environment assessment of deep mine based on analytic hierarchy process and fuzzy comprehensive evaluation

Case Studies in Thermal Engineering, 2020
There are many influencing factors for deep thermal environment, which will interact with each other. The analytic hierarchy process (AHP) and fuzzy comprehensive evaluation (FCE) are introduced to construct the evaluation model.
Dingyi Wei, Cui-Feng Du, Yifan Lin, Baomeng Chang, Yuan Wang   +4 more
semanticscholar   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Data-driven state monitoring of air preheater using density peaks clustering and evidential Knearest neighbour classifier [PDF]

MATEC Web of Conferences, 2019
Data-driven state monitoring requiring a little priori knowledge plays a key role for timely fault detection and is therefore of great importance for the safe and economical operation of the thermal power plant. The main drawback for most of the existing
Sha Peng, Wu Xiao, Shen Jiong, Liu Xichui, Wang Meihong   +4 more
doaj   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

New Energy Solid Waste Recycling: A Review and Outlook on Technologies from Structure Preservation to Structural Reconstruction

Separations
The booming clean energy industry has driven the expansion of photovoltaic (PV) and lithium-ion battery (LIB) sectors, causing the accumulation of new energy solid wastes such as wind turbine blades (WTB), PV modules and LIBs.
Bo Peng, Xinyan Zhang, Qiuxiang Lu, Zefeng Ge   +3 more
doaj   +1 more source

Performance Evaluation of a Chinese Lean Iron Ore as the Oxygen Carrier in Multi and Short-Time Redox Cycles

Applied Sciences, 2018
The performance of a Chinese lean iron ore as the oxygen carrier in chemical looping combustion was investigated in a fixed bed reactor. Considering the short contact time between the fuel gas and oxygen carrier in the sub-pilot experimental setup, the ...
Xudong Wang, Xiaojia Wang, Xiaoyu Hu, Yali Shao, Zhaoyang Jin, Baosheng Jin   +5 more
doaj   +1 more source