Results 41 to 50 of about 382,457 (261)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Recent Advances of the Electrochemical Hydrogenation of Biofuels and Chemicals from Furfural

Energies
With increasing energy demand and depletion of fossil fuels, the search for renewable energy sources has become imperative. Among them, biomass energy has attracted significant attention as it is clean, renewable, and abundant.
Huiyi Liang, Ke Liu, Xinghua Zhang, Qi Zhang, Lungang Chen, Yubao Chen, Xiuzheng Zhuang, Longlong Ma   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Experimental analysis of an enhanced biogas injera baking stove with an inverted conical combustion chamber

Scientific Reports
Traditional biomass-based injera baking stoves used in rural Ethiopia are characterized by low thermal efficiency, excessive fuel consumption, and significant greenhouse gas emissions, creating major environmental, health, and energy challenges.
Taha Abdella Geda, Demiss Alemu Ambie, Kamil Dino Adem   +2 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Parameter identification of condenser heat transfer model based on improved flower pollination algorithm

Scientific Reports
Condenser heat transfer parameters serve as critical indicators for assessing the operational status of condensers. However, these parameters cannot be directly obtained through measurement or inferred solely from condenser characteristic curves, which ...
Guodong Wang, Min Zhang, Jiayu Huang, Xingchen Liu, Qichang Wang, Dekui Shen   +5 more
doaj   +1 more source

Coarse-grained model and force field development for predicting phase change and thermal transport in polyethylene

Cailiao gongcheng, 2020
Coarse-grained model and force field for predicting phase change and thermal transport in meso-scale polyethylene were developed and its accuracy was validated.
CAI Zhuang-li, ZHAO Ling-ling, YU Xi-fan, CHEN Chao   +3 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Effect of Flue Gas Composition on Mercury Removal by Injecting Rice Husk-Derived Activated Carbon

Zhongguo dianli, 2019
The flue gas mercury removal experiment was carried out on a 0.3MW pilot scale circulating fluidized bed test facility by injecting biomass based activated carbon which is originally derived from rice husk and then modified by halogenated ammonium ...
Jun TAO, Xiaobing GU, Tianfang HUANG, Shuai LIU, Peng HU, Lu DONG, Yaji HUANG, Yufeng DUAN   +7 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source