Results 51 to 60 of about 1,071,012 (289)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Thermal–orbital evolution of Eris

Icarus
The large Kuiper Belt object (KBO) Eris is nearly as big as Pluto and has a small moon, Dysnomia. Constraints on the system's spin and orbit characteristics were recently used to argue for a dissipative Eris, requiring a differentiated structure but not necessarily a subsurface ocean.
Ryunosuke Akiba, Francis Nimmo
openaire   +2 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

A Complex Meso–Cenozoic History of Far-Field Extension and Compression: Evidence from Fission Track Analysis in the Helanshan Mountain Tectonic Belt, NW China

Applied Sciences
The Helanshan Mountain tectonic belt (HTB) is an intraplate deformation belt along the northwestern border of the Ordos Block in the North China Craton.
Cheng Wu, Yu Wang, Wanming Yuan, Liyun Zhou   +3 more
doaj   +1 more source

Process and Controlling Factors of Pore Evolution in Marine-Continental Transitional Black Shale—An Example From Permian Shanxi Formation in the Eastern Margin of Ordos Basin

Frontiers in Earth Science, 2022
Pore and pore network evolution of shale is critical for the evaluation the pore system in shale gas reservoirs. Thermal maturation effect acts as an indispensable role in porosity evolution.
Jin Wu, Jin Wu, Xiaowei Zhang, Xiaowei Zhang, Hao Xu, Yufeng Xiao, Yufeng Xiao, Guiying Liu, Lingfeng Jiang, Naier Deng, Zihe Ren   +10 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Thermal Evolution of the Impact‐Induced Cryomagma Chamber Beneath Occator Crater on Ceres

Geophysical Research Letters, 2019
The faculae in Occator Crater on dwarf planet Ceres are an accumulation of salts that have been interpreted as cryovolcanic products. Current age estimates from crater counting suggest a maximum 18‐Ma difference between the crater forming impact and the ...
M. A. Hesse, J. C. Castillo‐Rogez
doaj   +1 more source

Synergistical photo-thermal-catalysis of Zn2GeO4:xFe3+ for H2 evolution in NaBH4 hydrolysis reaction

Catalysis Communications, 2021
Herein, we reported the systematic investigation of synergistic photo-thermal-catalysis for NaBH4 hydrolysis reaction based on zinc orthogermanate. A series of Zn2GeO4:xFe3+ (x = 0 to 0.10) catalysts were prepared via solvothermal method.
Qiaoqi Li, Fei Wang, Xin Zhou, Jianmei Chen, Chao Tang, Lili Zhang   +5 more
doaj   +1 more source