Results 61 to 70 of about 1,071,012 (289)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Finite Element Modeling of an Aircraft Tire Rolling on a Steel Drum: Experimental Investigations and Numerical Simulations

Applied Sciences, 2018
The aim of this study is to investigate the thermal evolution of an aircraft tire rolling at high velocities up to take off values. As this kind of experiment is difficult to realize on a real runway, experimental tests were realized on aircraft tires ...
Iulian Rosu, Hélène L. Elias-Birembaux, Frédéric Lebon   +2 more
doaj   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

Compositional characterization and storage capacity of shale samples from La Luna and Conejo Formations (Middle Magdalena basin and the Eastern Cordillera): Implications for evaluation of cretaceous shale gas in Colombia

Boletín de Ciencias de la Tierra, 2015
Shale gas has become a major non-conventional energetical resource. La Luna Formation which is commonly considered as the main petroleum source rock, have also shown to be a major reservoir for shale gas resources.
Paula Andrea Pacheco Sintura, Agustín Cardona Molina, Farid B. Cortés   +2 more
doaj   +1 more source

Study on Thermal Effect of Aluminum-Air Battery

Nanomaterials, 2023
The heat released from an aluminum-air battery has a great effect on its performance and operating life during the discharge process. A theoretical model was proposed to evaluate the resulting thermal effect, and the generated heat was divided into the ...
Yajun Cai, Yunwei Tong, Yingjie Liu, Xinyu Li, Beiyang Chen, Feng Liu, Baowei Zhou, Yichun Liu, Zhenbo Qin, Zhong Wu, Wenbin Hu   +10 more
doaj   +1 more source

Modeling of Protostellar Clouds and their Observational Properties

, 2009
A physical model and two-dimensional numerical method for computing the evolution and spectra of protostellar clouds are described. The physical model is based on a system of magneto-gasdynamical equations, including ohmic and ambipolar diffusion, and a ...
A. Dedner, A. E. Dudorov, A. E. Dudorov, A. E. Dudorov, A. E. Dudorov, A. G. Zhilkin, A. Leger, C. J. Lintott, D. C. Black, D. R. Flower, D. Semenov, E. A. Bergin, E. Falgarone, E. Keto, E. L. O. Bakes, F. H. Shu, F. L. Schöier, J. C. Weingartner, J. M. C. Rawlings, K. Tassis, L. D. Landau, L. Spitzer, M. Tafalla, M. Tafalla, N. J. Evans II, P. F. Goldsmith, P. Kunasz, R. B. Larson, R. I. Klein, S. N. Zamozdra, S. Zhou, T. J. Millar, T. Matsumoto, T. Miyoshi, T. Nakano, V. I. Shematovich, V. Ossenkopf, W. R. Webber, Ya. N. Pavlyuchenkov, Ya. N. Pavlyuchenkov, Ya. N. Pavlyuchenkov, Ya. Pavlyuchenkov, Ya. Pavlyuchenkov, Ya. Pavlyuchenkov   +43 more
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Tectonic-structural systems of Mars: Is it possible to use them to reconstruct its thermal evolution? [PDF]

Geofísica Internacional, 2004
This work tries to establish the possible relationship among cortical stresses evidenced by faults mapped in the surface and thermal evolution on Mars.
J. F. Valdés-Galicia, Antonio H. Barosio   +1 more
doaj  

Geological characteristics and shale gas potential of Lower Cambrian Hetang Formation in Lower Yangtze region: a case study of Jiangshan-Tonglu area, western Zhejiang province

Shiyou shiyan dizhi, 2020
The high degree of thermal evolution is a main factor restricting the development of the Lower Paleozoic shale gas in the Yangtze region. The latest field study shows that there is a region with relatively lower thermal evolution in the Jiangshan-Tonglu ...
Wenbo ZHU, Xunhua ZHANG, Xiuqi WANG, Zhongdang QU, Zhengqing HUANG, Daorong ZHOU   +5 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source