Results 71 to 80 of about 508,590 (314)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Convective Concrete: additive manufacturing to facilitate activation of thermal mass

Spool, 2017
Convective Concrete is about a research-driven design process of an innovative thermal mass concept. The goal is to improve building energy efficiency and comfort levels by addressing some of the shortcomings of conventional building slabs with high ...
Dennis de Witte, Ulrich Knaack, Marie de Klijn-Chevalerias, Roel Loonen, Jan Hensen, Gregor Zimmerman   +5 more
doaj   +2 more sources

On the Influence of Thermal Mass and Natural Ventilation on Overheating Risk in Offices

Buildings, 2018
Free cooling strategies are gaining importance in design practice due to the increased risk of overheating in well-insulated buildings with high internal loads such as offices.
Arianna Brambilla, Jerome Bonvin, Flourentzos Flourentzou, Thomas Jusselme   +3 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Thermal behavior of native, washed and steam exploded lignocellulosic biomass samples [PDF]

, 2013
The aim of this study was to evaluate the chemical changes in the main components (cellulose, hemicellulose and lignin) of various lignocellulosic biomass samples during the steam explosion pretreatment. Pyrolysis-gas chromatography/mass spectrometry (Py-
Jakab, Emma, Sebestyén, Zoltán, May, Zoltán, Kati, Réczey, Sipos, Bálint   +4 more
core  

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Review of Molten-Salt Thermocline Tank Modeling for Solar Thermal Energy Storage

, 2013
Molten-salt thermocline tanks are a low-cost option for thermal energy storage in concentrating solar power systems. A review of previous experimental and numerical thermocline tank studies is performed to identify key issues associated with tank design ...
Yang, Z., Garimella, S V, Flueckiger, S. M.   +2 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Effect of solid thermal conductivity and particle-particle contact on effective thermodiffusion coefficient in porous media [PDF]

, 2011
Transient mass transfer associated to a thermal gradient through a saturated porous medium is studied experimentally and theoretically to determine the effect of solid thermal conductivity and particle-particle contact on thermodiffusion processes.
Davarzani, Hossein, H. Davarzani, Quintard, Michel, M. Quintard, M. Marcoux, Marcoux, Manuel   +5 more
core   +1 more source

Rocks, Clays, Water, and Salts: Highly Durable, Infinitely Rechargeable, Eminently Controllable Thermal Batteries for Buildings

Geosciences, 2013
Materials that store the energy of warm days, to return that heat during cool nights, have been fundamental to vernacular building since ancient times.
Alan W. Rempel, Alexandra R. Rempel
doaj   +1 more source