Results 41 to 50 of about 3,748,225 (281)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Numerical Simulation and Optimized Field-Driven Design of Triple Periodic Minimal Surface Structure Liquid-Cooling Radiator

Energies
This work investigates the design of liquid-cooled heat sinks for IGBT modules via optimizing the Triple Periodic Minimal Surface (TPMS) structure. The performance of heat sinks with different porosity TPMS structures was compared through the finite ...
Zhuopei Lv, Xinbo Chai, Fuyin Wei, Hongkai Yang, Chao Wu, Jianping Shi   +5 more
doaj   +1 more source

Stiffness maximization for thermal deformation under thermal conductivity constraint using topology optimization

Nihon Kikai Gakkai ronbunshu, 2015
Cooling structures require sufficient thermal conductivity. However, structure with thermal conducting could suffer high temperature, and thermal deformation could become serious. Thus, designing structures suppressing thermal deformation is an important
Takafumi NISHIZU, Akihiro TAKEZAWA, Mitsuru KITAMURA   +2 more
doaj   +1 more source

Optimal thermal refrigerator

, 2009
4 pages, 2 ...
Allahverdyan, Armen E., Hovhannisyan, Karen, Mahler, Guenter   +2 more
openaire   +2 more sources

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Crystallization of Biogenic Hydroxyapatite: Phase Purity and Morphological Control via Successive Annealing and Grinding

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
Hydroxyapatite (HAp) derived from biogenic sources offers a sustainable and cost-effective alternative to synthetic materials, yet controlling its crystal structure and morphology remains a key challenge.
H. Esma Okur
doaj   +1 more source

An Integrated Prediction and Optimization Model of a Thermal Energy Production System in a Factory Producing Furniture Components

Energies, 2020
Thermal energy is an important input of furniture components production. A thermal energy production system includes complex, non-linear, and changing combustion processes.
Halil Akbaş, Gültekin Özdemir
doaj   +1 more source

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source