Results 41 to 50 of about 165,623 (262)
HeliyonIn order to generate clean electricity from thermal energy, a hybrid electrochemical system is conceptually developed by coupling the proton exchange membrane fuel cell (PEMFC) and solid oxide electrolyzer cell (SOEC).
Armin Abdollahipour, Hoseyn Sayyaadi
doaj +1 more source
Energy Conversion and Management: XInvestigating the impact of dye compounds on cell performance is crucial for advancing dye-sensitized solar cells (DSSCs). This research focuses on the sensitivity analysis of the effect of critical parameters to enhance DSSC efficiency using a thermo ...
Mona Rahmatian, Hoseyn Sayyaadi
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Molecular Oncology, EarlyView.A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel +12 more
wiley +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Optimal Control of Thermally Convected Fluid Flows [PDF]
SIAM Journal on Scientific Computing, 1998 The optimal control problem is: minimize vorticity in viscous steady incompressible thermally convected flow in a smooth bounded 2-dimensional domain \(\Omega\) by controlling the temperature on the boundary \(\Gamma\). The state equations for the velocity \({\mathbf u}\), the pressure \(p\) and the temperature \(T\) in \(\Omega\) are \[ \begin{aligned}
Kazufumi Ito, S. S. Ravindran
openaire +1 more source