Results 51 to 60 of about 164,686 (263)

Multiobjective design optimization of parabolic trough collectors

open access: yesScientific Reports, 2022
Despite the large amount of research conducted on PTC performance analysis, few and rare numbers of research have considered the design optimization of PTCs.
Mohamed Mahran Kasem
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Optimization-Based Network Identification for Thermal Transient Measurements

open access: yesEnergies, 2021
Network identification by deconvolution is a proven method for determining the thermal structure function of a given device. The method allows to derive the thermal capacitances as well as the resistances of a one-dimensional thermal path from the ...
Nils J. Ziegeler   +2 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Indoor photovoltaics: A numerical model of dye-sensitized solar cells based on indoor illumination for the Internet of Things applications

open access: yesEnergy Conversion and Management: X
Since dye-sensitized solar cells (DSSC) have a suitable efficiency in the invisible region, they present a promising avenue for sustainable energy generation, particularly in the context of indoor environments where ambient lighting prevails.
Mona Rahmatian   +2 more
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Radial movement optimization (RMO) technique for solving unit commitment problem in power systems

open access: yesJournal of Electrical Systems and Information Technology, 2018
Unit commitment (UC) is one of the nonlinear optimization problems with linear and nonlinear constraints. In this work, radial movement optimization (RMO) is employed to solve the optimal thermal unit commitment problem. Radial movement optimization is a
Vanithasri M.   +2 more
doaj   +1 more source

Gradient-based optimization of spacecraft and aircraft thermal design

open access: yesAviation, 2020
Steady-case thermal analysis plays an important role in dimensioning thermal control systems for spacecrafts and aircrafts. Usually a trial and error approach is used based on engineering judgement and experience.
Laurynas Mačiulis, Rimantas Belevičius
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

open access: yesFEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane   +11 more
wiley   +1 more source

OPTIMIZATION OF THERMAL LAYOUT DESIGN OF ELECTRONIC EQUIPMENTS ON THE PRINTED CIRCUIT BOARD

open access: yesJournal of Engineering, 2006
A thermal layout modeling and optimization routine for a Printed Circuit Board (PCB) has been made in the present work. The thermal model includes the modeling of electronic components based on thermal resistances and the PCB as a flat plate with ...
Ihsan Y. Hussain   +1 more
doaj   +1 more source

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