Results 51 to 60 of about 696,535 (296)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Crystallization of Biogenic Hydroxyapatite: Phase Purity and Morphological Control via Successive Annealing and Grinding

Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi
Hydroxyapatite (HAp) derived from biogenic sources offers a sustainable and cost-effective alternative to synthetic materials, yet controlling its crystal structure and morphology remains a key challenge.
H. Esma Okur
doaj   +1 more source

Environment Optimization Scheme Based on Edge Computing Using PSO for Efficient Thermal Comfort Control in Resident Space

Actuators, 2021
With the fast development of infrastructure and communication technology, the Internet of Things (IoT) has become a promising field. Ongoing research is looking at the smart home environment as the most promising sector that adopts IoT and cloud ...
Rongxu Xu, Wenquan Jin, Dohyeun Kim
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Topology optimization for near-junction thermal spreading of electronics in ballistic-diffusive regime

iScience, 2023
Summary: Hotspots in electronic devices can cause overheating and reduce performance. Enhancing the thermal spreading ability is critical for reducing device temperature to improve the reliability. However, as devices shrink, phonon ballistic effects can
Zheng-Lai Tang, Yang Shen, Han-Ling Li, Bing-Yang Cao   +3 more
doaj   +1 more source

A three-stage optimization methodology for envelope design of passive house considering energy demand, thermal comfort and cost [PDF]

, 2020
Due to reducing the reliance of buildings on fossil fuels, Passive House (PH) is receiving more and more attention. It is important that integrated optimization of passive performance by considering energy demand, cost and thermal comfort.
Feng, W, Lu, S, Wang, R
core  

Optimization-based design of a heat flux concentrator [PDF]

, 2017
To gain control over the diffusive heat flux in a given domain, one needs to engineer a thermal metamaterial with a specific distribution of the generally anisotropic thermal conductivity throughout the domain.
Ciarbonetti, Ángel A., Fachinotti, Víctor D., Peralta, Ignacio   +2 more
core   +2 more sources

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Multiobjective design optimization of parabolic trough collectors

Scientific Reports, 2022
Despite the large amount of research conducted on PTC performance analysis, few and rare numbers of research have considered the design optimization of PTCs.
Mohamed Mahran Kasem
doaj   +1 more source

Optimization-Based Network Identification for Thermal Transient Measurements

Energies, 2021
Network identification by deconvolution is a proven method for determining the thermal structure function of a given device. The method allows to derive the thermal capacitances as well as the resistances of a one-dimensional thermal path from the ...
Nils J. Ziegeler, Peter W. Nolte, Stefan Schweizer   +2 more
doaj   +1 more source