Results 161 to 170 of about 6,447 (219)

GPMelt: A hierarchical Gaussian process framework to explore the dark meltome of thermal proteome profiling experiments. [PDF]

PLoS Comput Biol
Le Sueur C, Rattray M, Savitski M.
europepmc   +1 more source

AI‐Physics‐Experiment Trinity for Integrated Protein Dynamics Modeling

Advanced Science, Volume 13, Issue 41, 22 July 2026.
This review unites experiments, physics‐based simulations, and AI as a synergistic triad for protein dynamics modeling. It highlights integrative strategies, resolves sampling and forcefield bottlenecks, and outlines challenges and future directions for accurate, interpretable conformational ensemble prediction.
Chen Shi, Minying Low, Peng Xiu, Kresten Lindorff‐Larsen, Yong Wang   +4 more
wiley   +1 more source

TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain

Advanced Science, Volume 13, Issue 40, 17 July 2026.
TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando, Emanuele Buratti, Francesca Paron   +2 more
wiley   +1 more source

Unlocking the Full Potential of Immunotherapy: Visualizing and Remodeling the Tumor Immune Microenvironment With Aggregation‐Induced Emission Luminogens

Aggregate, Volume 7, Issue 7, July 2026.
An AIEgen‐based immunotherapy paradigm that integrates rational photophysical engineering, high‐fidelity interrogation of immune–tumor interactions, and synergistic tumor immune microenvironment (TIME) remodeling is highlighted. Recent progress in molecular design, immune imaging, and combinational therapeutic strategies is summarized, together with ...
Xiangyu Tan, Miaozhuang Fan, Yuting Li, Guihua Wang, Haotian Li, Eberechukwu Maryann Okoli, Yonghong Shao, Gaixia Xu, Zhourui Xu   +8 more
wiley   +1 more source

Caenorhabditis elegans and Drosophila melanogaster as Model Organisms in Biofactor Research

BioFactors, Volume 52, Issue 4, July/August 2026.
This review presents Caenorhabditis elegans and Drosophila melanogaster as powerful and ethically sound invertebrate model organisms that can be used to investigate nutritional science questions relating to biofactors. Such nutritional phenotyping studies can bridge the gap between in vitro studies and in vivo research in mammals.
Kai Lüersen, Thomas Roeder, Gerald Rimbach   +2 more
wiley   +1 more source

Recombinant Protein Expression in Rhodococcus species

Current Protocols, Volume 6, Issue 7, July 2026.
Abstract Producing recombinant bacterial proteins is essential for elucidating their structure and function, making efficient overexpression systems a key requirement. Escherichia coli is widely used for this purpose, particularly for bacterial proteins, but certain targets remain challenging to express or obtain as soluble protein.
Michael Akintubosun, Melanie A. Higgins
wiley   +1 more source

Role of LncSNHG5 in MAFLD: Mechanisms of Arid1a K391 lactylation and lipid accumulation

Clinical and Translational Medicine, Volume 16, Issue 7, July 2026.
1. SNHG5 is significantly upregulated in MAFLD. 2. SNHG5 promotes hepatic lipid accumulation by downregulating MCT1 and regulating intracellular lactate metabolism. 3. SNHG5 drives lactylation of Arid1a at the K391 residue through the P300 and HBO1 acyltransferases. Abstract Introduction Metabolic dysfunction‐associated fatty liver disease (MAFLD) is a
Xinmiao Li, Feng Jiang, Binbo Fang, Lifan Lin, Jianjian Zheng, Tanzhou Chen   +5 more
wiley   +1 more source

Inflammaging: Experimental Insights and Translational Advances

European Journal of Immunology, Volume 56, Issue 7, July 2026.
Inflammaging is a chronic, low‐grade, sterile inflammation associated with aging that contributes to age‐related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome‐based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease ...
Andrea Cossarizza
wiley   +1 more source

Differential Proteomic Analysis to Reveal the Mechanism of Heat Damage in Soybean Using a Data‐Independent Acquisition (DIA) Strategy

Food Safety and Health, Volume 4, Issue 3, Page 621-630, July 2026.
Heat‐stressed soybeans adapt to elevated temperatures through coordinate regulation of destructive and protective protein expression ‐ suppressing detrimental proteins while enhancing beneficial ones. ABSTRACT Soybean represents the largest imported agricultural product in China. Imported soybeans are typically transported via maritime shipping. During
Pengdi Ding, Qinfei Xie, Jiajing Duan, Yinghao Feng, Fengzhong Wang, Yufeng Sun   +5 more
wiley   +1 more source