Results 171 to 180 of about 6,447 (219)
Food Science &Nutrition, Volume 14, Issue 7, July 2026.Sulforaphane modulates mTOR, Nrf2, NF‐κB, and AMPK/PGC‐1α pathways to protect skeletal muscle and enable precision‐medicine intervention in ICU‐acquired weakness, sarcopenia, and diabetic myopathy. ABSTRACT Sulforaphane (SFN), a bioactive isothiocyanate abundant in cruciferous vegetables, has attracted growing interest as a potential nutraceutical ...
Minru Zhao +8 more
wiley +1 more source
A personal 360° view of applications of ‘biomimetic’ molecular recognition
Journal of Chemical Technology &Biotechnology, Volume 101, Issue 7, Page 1300-1311, July 2026.Abstract Molecular recognition between biological molecules has formed the basis for innumerable applications in biotechnology for the last seven decades or so. Techniques such as affinity chromatography, solid‐phase and aqueous two‐phase extraction, affinity precipitation, biomimetic catalytic systems, biosensors and molecular imprinting all exploit ...
Christopher R Lowe
wiley +1 more source
Mass Spectrometry Structural Proteomics Enabled by Limited Proteolysis and Cross‐Linking
Mass Spectrometry Reviews, Volume 45, Issue 4, Page 644-671, July/August 2026.ABSTRACT The exploration of protein structure and function stands at the forefront of life science and represents an ever‐expanding focus in the development of proteomics. As mass spectrometry (MS) offers readout of protein conformational changes at both the protein and peptide levels, MS‐based structural proteomics is making significant strides in the
Haiyan Lu +4 more
wiley +1 more source
MedComm, Volume 7, Issue 7, July 2026.This study deciphers the functional crosstalk between 2‐hydroxyisobutyrylation (Khib) and phosphorylation in driving esophageal squamous cell carcinoma (ESCC) metastasis. Through multi‐omics and machine learning, we developed a plasma protein signature for noninvasive detection of lymph node metastasis.
Junyi Li +20 more
wiley +1 more source
Cellular Senescence and Aging: Mechanisms, Disease Convergence, and Therapeutic Frontiers
MedComm, Volume 7, Issue 7, July 2026.This schematic illustrates the hierarchical and interconnected nature of the primary molecular hallmarks of aging. The progression of aging is driven by a convergence of intrinsic molecular insults. Within the nucleus, genomic instability and telomere attrition trigger persistent DDR, accompanied by extensive epigenetic alterations.
Guowei Cai +10 more
wiley +1 more source
ChemistryOpen, Volume 15, Issue 7, July 2026.Several factors including hydrophobic packing, electrostatic interactions and hydrogen bonding influence thermostability of proteins. Mechanisms of thermal adaptation were investigated via structural and mutational studies. Stability predictions were enhanced by combining thermodynamic data with ML‐based computer models for protein engineering ...
Sermarajan Arunachalam +2 more
wiley +1 more source
Protein Science, Volume 35, Issue 7, July 2026.Abstract Polyproline II (PPII) helices are extended left‐handed secondary structures increasingly recognized for their roles in molecular recognition, signaling and within intrinsically disordered regions of proteins. Despite their functional importance, predicting regions with propensity to form PPII helices from sequence alone remains challenging due
Rubén López‐Sánchez +3 more
wiley +1 more source
Thermal proteome profiling of plasma proteins that bind oxidized phospholipids
Oxidized LDL (oxLDL) is a harmful proinflammatory molecule that contributes to the development of atherosclerosis. The body has three important defense mechanisms against oxLDL, including opsonization by natural IgM antibodies, enzymatic degradation/ modification and masking by other circulating proteins.
openaire +1 more source
The FEBS Journal, Volume 293, Issue 14, Page 4288-4305, July 2026.Congenital dyserythropoietic anemia type I (CDA‐I) arises from mutations in Codanin1 and CDIN1. Using quantitative biophysical approaches, we show that disease‐associated mutations disrupt the CDIN1‐Codanin1 complex. Our findings provide critical insights into the molecular mechanism that links protein dysfunction to disturbing chromatin arrangement ...
Martin Stojaspal +8 more
wiley +1 more source
Variability in intracellular localization of D‐amino acid oxidase in choroid plexus epithelial cells
The FEBS Journal, Volume 293, Issue 14, Page 4358-4373, July 2026.D‐amino acid oxidase (DAO) in choroid plexus epithelial cells (CPECs) shows vesicle‐like localization by histological and super‐resolution analyses. DAO colocalizes with peroxisomal, Golgi, endosomal, lysosomal, autophagosomal, and exosomal markers, indicating diverse subcellular distribution. This suggests DAO is transported within CPECs to metabolize
Koji Ono +3 more
wiley +1 more source