Results 51 to 60 of about 6,447 (219)

From the Discovery of Targets to Delivery Systems: How to Decipher and Improve the Metallodrugs’ Actions at a Molecular Level

Pharmaceutics, 2023
Metals are indispensable for the life of all organisms, and their dysregulation leads to various disorders due to the disruption of their homeostasis. Nowadays, various transition metals are used in pharmaceutical products as diagnostic and therapeutic ...
Ilaria Iacobucci, Sara La Manna, Irene Cipollone, Vittoria Monaco, Luisa Canè, Flora Cozzolino   +5 more
doaj   +1 more source

Aggregation and disaggregation features of the human proteome

Molecular Systems Biology, 2020
Protein aggregates have negative implications in disease. While reductionist experiments have increased our understanding of aggregation processes, the systemic view in biological context is still limited.
Tomi A Määttä, Mandy Rettel, Sindhuja Sridharan, Dominic Helm, Nils Kurzawa, Frank Stein, Mikhail M Savitski   +6 more
doaj   +1 more source

Natural Product Alantolactone Targeting AKR1C1 Suppresses Cell Proliferation and Metastasis in Non-Small-Cell Lung Cancer

Frontiers in Pharmacology, 2022
Non-small-cell lung cancer (NSCLC) is one of the leading causes of cancer-related deaths, characterized by high invasion and metastasis. Aldo-keto reductase family 1 member C1 (AKR1C1) plays an important role in cancer cell proliferation and metastasis ...
Zhiwen Fu, Zhiwen Fu, Shijun Li, Shijun Li, Jinmei Liu, Jinmei Liu, Cong Zhang, Cong Zhang, Chen Jian, Chen Jian, Lulu Wang, Lulu Wang, Yu Zhang, Yu Zhang, Chen Shi, Chen Shi   +15 more
doaj   +1 more source

R code for thermal proteome profiling analysis [PDF]

<p>R code for the analysis of LCS3 thermal proteome profiling in H23 lung cancer adenocarcinoma cells.</p> <p>*R code in this version is unchanged from v2. Configuration and data files have been provided in this version to aid users.<
Johnson, Fraser, Liu, Alvin, Morin, Gregg, Lockwood, William   +3 more
core   +1 more source

Computational analysis of ligand dose range thermal proteome profiles [PDF]

, 2020
Abstract Detecting ligand-protein interactions in living cells is a fundamental challenge in molecular biology and drug research. Proteome-wide profiling of thermal stability as a function of ligand concentration promises to tackle this challenge. We present a statistical analysis method with reliable control of the false discovery rate
Kurzawa, Nils, Becher, Isabelle, Sridharan, Sindhuja, Franken, Holger, Mateus, André, Anders, Simon, Bantscheff, Marcus, Huber, Wolfgang, Savitski, Mikhail M.   +8 more
openaire   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Exploring direct and indirect targets of current antileishmanial drugs using a novel thermal proteomics profiling approach

Frontiers in Cellular and Infection Microbiology, 2022
Visceral leishmaniasis (VL), caused by Leishmania infantum, is an oft-fatal neglected tropical disease. In the absence of an effective vaccine, the control of leishmaniasis relies exclusively on chemotherapy.
Ana Victoria Ibarra-Meneses, Ana Victoria Ibarra-Meneses, Audrey Corbeil, Audrey Corbeil, Victoria Wagner, Victoria Wagner, Francis Beaudry, Francis Beaudry, Rubens L. do Monte-Neto, Christopher Fernandez-Prada, Christopher Fernandez-Prada   +10 more
doaj   +1 more source

Bioconductor packages for analysis of Thermal Proteome Profiling data

, 2020
Thermal proteome profiling (TPP) is a mass spectrometry-based technology which was originally developed to identify drug (off-)targets on a proteome-wide scale. The assay is built on the principle of the cellular thermal shift assay which is that proteins inside living cells may be modulated in their thermal stability by ligand binding.
Kurzawa, Nils, Childs, Dorothee, Franken, Holger, Savitski, Mikhail M., Huber, Wolfgang   +4 more
openaire   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Adenosine triphosphate as a modulator of protein interactions and stability

FEBS Open Bio, EarlyView.
ATP is best known as the cell's energy currency, but it also shapes how proteins fold, interact, aggregate and form biomolecular condensates. This review explains the emerging physical principles behind these effects, including weak binding to charged protein regions, magnesium‐dependent behaviour and concentration‐dependent control of protein ...
Shuyuan Tan, Robin Curtis
wiley   +1 more source