Results 51 to 60 of about 766,439 (267)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Development and grain yield of barley genotypes according to sowing date

Revista Thema
This study aimed to determine the length of subperiods, development cycle, yield, and grain quality of barley genotypes at different sowing dates. Three experimental lines from a barley breeding program Barley01, Barley02, and Barley03 as well as three ...
Mateus Possebon Bortoluzzi, Lucas Ughini Marques, Adriana Favaretto, Laura Valentina Caus Maldaner, Alessandra Gallina   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Stratospheric thermal damping times [PDF]

Geophysical Research Letters, 1997
Radiative damping of stratospheric temperature waves has wide implications for stratospheric physical processes. Damping is linearly parameterized as proportional to the local temperature. Thermal damping is calculated using the Goddard radiative transfer model and 17 years observations.
Paul A. Newman, Joan E. Rosenfield
openaire   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Influence of an abscisic acid (ABA) seed coating on seed germination rate and timing of Bluebunch Wheatgrass

Ecology and Evolution, 2019
Semi‐arid rangeland degradation is a reoccurring issue throughout the world. In the Great Basin of North America, seeds sown in the fall to restore degraded sagebrush (Artemisia spp.) steppe plant communities may experience high mortality in winter due ...
William C. Richardson, Turmandakh Badrakh, Bruce A. Roundy, Zackary T. Aanderud, Steven L. Petersen, Phil S. Allen, Dallin R. Whitaker, Matthew D. Madsen   +7 more
doaj   +1 more source

The Time in Thermal Time

Journal for General Philosophy of Science
Accepted for publication in the Journal for General Philosophy of Science, as part of the Special Issue: On Time in the Foundations of Physics (eds. Andrea Oldofredi & Cristian Lopez).
openaire   +3 more sources

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Determinação do tempo térmico para o desenvolvimento de mudas de eucalipto na fase de enraizamento Determination of thermal time for the development of eucalyptus seedlings during rooting phase

Revista Brasileira de Engenharia Agrícola e Ambiental, 2012
O gênero Eucalyptus possui destaque em plantios florestais comerciais em virtude de apresentar crescimento rápido e ser adaptado às condições climáticas do Brasil.
Aline S. de Oliveira, Antonio J. Steidle Neto, Aristides Ribeiro, Nilton Jr. L. Rascon, Yhasmin P. Rody, André Q. de Almeida   +5 more
doaj   +1 more source