Results 61 to 70 of about 16,748,922 (299)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Development and grain yield of barley genotypes according to sowing date

Revista Thema
This study aimed to determine the length of subperiods, development cycle, yield, and grain quality of barley genotypes at different sowing dates. Three experimental lines from a barley breeding program Barley01, Barley02, and Barley03 as well as three ...
Mateus Possebon Bortoluzzi, Lucas Ughini Marques, Adriana Favaretto, Laura Valentina Caus Maldaner, Alessandra Gallina   +4 more
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

Thermal stresses in pipes [PDF]

, 2002
This study presents results about thermal stresses in externally heated pipes that are subjected to different flow types: laminar flow, turbulent flow, and pulsating flow. The effect o f flow Reynolds number on thermal stresses in the pipe is studied. To
Al-Zaharnah, Iyad
core   +2 more sources

Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers

FEBS Letters, EarlyView.
Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui, Agnes Banreti, Armelle L. Ernst, Guillaume Leseigneur, Uwe J. Meierhenrich   +4 more
wiley   +1 more source

Influence of an abscisic acid (ABA) seed coating on seed germination rate and timing of Bluebunch Wheatgrass

Ecology and Evolution, 2019
Semi‐arid rangeland degradation is a reoccurring issue throughout the world. In the Great Basin of North America, seeds sown in the fall to restore degraded sagebrush (Artemisia spp.) steppe plant communities may experience high mortality in winter due ...
William C. Richardson, Turmandakh Badrakh, Bruce A. Roundy, Zackary T. Aanderud, Steven L. Petersen, Phil S. Allen, Dallin R. Whitaker, Matthew D. Madsen   +7 more
doaj   +1 more source

The Time in Thermal Time

Journal for General Philosophy of Science
Accepted for publication in the Journal for General Philosophy of Science, as part of the Special Issue: On Time in the Foundations of Physics (eds. Andrea Oldofredi & Cristian Lopez).
openaire   +3 more sources

Stratospheric thermal damping times [PDF]

Geophysical Research Letters, 1997
Radiative damping of stratospheric temperature waves has wide implications for stratospheric physical processes. Damping is linearly parameterized as proportional to the local temperature. Thermal damping is calculated using the Goddard radiative transfer model and 17 years observations.
Paul A. Newman, Joan E. Rosenfield
openaire   +1 more source

Artificial molecular machines and motors—Design and control of nanoscale motion

FEBS Letters, EarlyView.
Molecules are constantly moving because of thermal fluctuations, but random motion alone cannot be exploited to perform directional tasks. Artificial molecular machines use chemical, electrical, or light energy to bias this motion. Molecular shuttles, rotary motors, and supramolecular pumps illustrate how nanoscale movement can be controlled and ...
Leonardo Andreoni, Alberto Credi
wiley   +1 more source