Results 71 to 80 of about 766,439 (267)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

Molecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht, Sameer Gupta, Amrita Chaurasia, Manisha Sachan   +3 more
wiley   +1 more source

Desenvolvimento vegetativo e reprodutivo de cultivares de trigo e sua associação com a emissão de folhas Vegetative and reproductive development of wheat cultivars and its association with leaf appearance

Ciência Rural, 2009
O objetivo deste estudo foi determinar a relação da duração das fases vegetativa, reprodutiva e total do ciclo de desenvolvimento com o número final de folhas e com a velocidade de aparecimento de folhas no colmo principal, em cultivares brasileiras de ...
Lidiane Cristine Walter, Nereu Augusto Streck, Hamilton Telles Rosa, Cleber Maus Alberto, Felipe Brendler de Oliveira   +4 more
doaj  

Desenvolvimento vegetativo de duas cultivares de oliveira na fase de muda Vegetative development of two olive cultivars in seedling phase

Ciência Rural, 2012
O desenvolvimento de plantas, influenciado pela temperatura do ar, pode ser estimado através do conceito de filocrono, definido como o intervalo de tempo entre o surgimento sucessivo de folhas em uma haste, sendo o tempo expresso em °C dia e o filocrono ...
Priscila Maria Martins Lisboa, Fabrina Bolzan Martins, Maria Inês Nogueira Alvarenga, João Vieira Neto, Diogo da Fonseca Reis   +4 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Temperature and storage time strongly affect the germination success of perennial Euphorbia species in Mediterranean regions

Ecology and Evolution, 2019
This study aims to explore the effect of environmental factors (temperature, light, storage time) on germination response and dormancy patterns in eight Mediterranean native wildplants, belonging to the Euphorbia L. genus.
Antonia Cristaudo, Stefania Catara, Antonio Mingo, Alessia Restuccia, Andrea Onofri   +4 more
doaj   +1 more source

Base temperature and simulation model for nodes appearance in cape gooseberry (Physalis peruviana L.) Temperatura base e modelo de simulação da aparição de nós em plantas de fisalis(Physalis peruviana L.)

Revista Brasileira de Fruticultura, 2008
Data was analyzed on development of the solanaceen fruit crop Cape gooseberry to evaluate how well a classical thermal time model could describe node appearance in different environments.
Melba Ruth Salazar, James W. Jones, Bernardo Chaves, Alexander Cooman, Gerhard Fischer   +4 more
doaj   +1 more source

Thermal Time Constant CNN-Based Spectrometry for Biomedical Applications. [PDF]

Sensors (Basel), 2023
Strąkowska M, Strzelecki M.
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source