Results 71 to 80 of about 991,745 (315)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Influence of an abscisic acid (ABA) seed coating on seed germination rate and timing of Bluebunch Wheatgrass

Ecology and Evolution, 2019
Semi‐arid rangeland degradation is a reoccurring issue throughout the world. In the Great Basin of North America, seeds sown in the fall to restore degraded sagebrush (Artemisia spp.) steppe plant communities may experience high mortality in winter due ...
William C. Richardson, Turmandakh Badrakh, Bruce A. Roundy, Zackary T. Aanderud, Steven L. Petersen, Phil S. Allen, Dallin R. Whitaker, Matthew D. Madsen   +7 more
doaj   +1 more source

Parametric Analysis of Effective Tissue Thermal Conductivity, Thermal Wave Characteristic, and Pulsatile Blood Flow on Temperature Distribution during Thermal Therapy

, 2017
This study examines the coupled effects of pulsatile blood flow in a thermally significant blood vessel, the effective thermal conductivity of tumor tissue, and the thermal relaxation time in solid tissues on the temperature distributions during thermal ...
Shih, Tzu-Ching;Huang, Huang-Wen;Wei, Wei-Che;Horng, Tzyy-Leng
core   +1 more source

Evolution and Modern Approaches for Thermal Analysis of Electrical Machines [PDF]

, 2009
In this paper, the authors present an extended survey on the evolution and the modern approaches in the thermal analysis of electrical machines. The improvements and the new techniques proposed in the last decade are analyzed in depth and compared in ...
Shanel, M., D. STATON, M. SHANEL, Aldo Boglietti, Andrea Cavagnino, C. MEJUTO, Carlos Mejuto, David Staton, M. MUELLER, Mueller, M., Staton, D., Mejuto, C., Martin Shanel, Boglietti, Aldo, Cavagnino, Andrea, Markus Mueller   +15 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Determinação do tempo térmico para o desenvolvimento de mudas de eucalipto na fase de enraizamento Determination of thermal time for the development of eucalyptus seedlings during rooting phase

Revista Brasileira de Engenharia Agrícola e Ambiental, 2012
O gênero Eucalyptus possui destaque em plantios florestais comerciais em virtude de apresentar crescimento rápido e ser adaptado às condições climáticas do Brasil.
Aline S. de Oliveira, Antonio J. Steidle Neto, Aristides Ribeiro, Nilton Jr. L. Rascon, Yhasmin P. Rody, André Q. de Almeida   +5 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Effects of Temperature on Seed Germination of Plantago lanceolata and Management in Carya illinoinensis Production

Plants, 2019
Plantago lanceolata L. (buckhorn plantain) is an encroaching winter weed described as one of the most successful noncultivated colonizing species around the world. Control of P. lanceolata in southeastern USA Carya illinoinensis (Wangenh.) K.
Timothy L. Grey, Kayla M. Eason, Lenny Wells, Nicholas T. Basinger   +3 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Comparison of two different models for pile thermal response test interpretation [PDF]

, 2014
Thermal response tests (TRTs) are regularly used to characterise the thermal resistance of borehole heat exchangers and to assess the thermal conductivity of the surrounding ground.
Loveridge, F.A., Powrie, W., Powrie, W, William Powrie, Nicholson, D., Fleur Loveridge, Loveridge, F, Nicholson, D, Duncan Nicholson   +8 more
core   +1 more source