Results 101 to 110 of about 46,499 (284)
Comparative Genomics and Functional Evidence for Convergent Adaptation to Hypoxia in Mammals
Integrative Zoology, EarlyView.This study reveals convergent selection in mammals adapted to hypoxia. Functional assays demonstrate that amino acid mutations reduce oxidative stress, attenuate hypoxia‐induced injury, and modulate the hypoxia‐inducible transcription factor (HIF)‐driven hypoxic response.
Hao Dong +5 more
wiley +1 more source
Adipsin and adipocyte-derived C3aR1 regulate thermogenic fat in a sex-dependent fashion
JCI InsightThermogenesis in beige/brown adipose tissues can be leveraged to combat metabolic disorders such as type 2 diabetes and obesity. The complement system plays pleiotropic roles in metabolic homeostasis and organismal energy balance with canonical effects ...
Lunkun Ma +7 more
doaj +1 more source
Integrative Zoology, EarlyView.A total of 435 non‐redundant metagenome‐assembled genomes (MAGs) were obtained from fecal samples of Taihangshan macaque across all four seasons. The alpha diversity of the gut microbiome in spring and winter was significantly higher than in summer and autumn. Furthermore, marked differences were detected in functional pathways and carbohydrate enzymes
Yanyan Zhou +6 more
wiley +1 more source
Andrology, EarlyView.Abstract Background Myocyte enhancer factor 2 transcription factors regulate essential transcriptional programs in various cell types. The activity of myocyte enhancer factor 2 factors is modulated through interactions with cofactors, chromatin remodelers, and other regulatory proteins, which are dependent on cell context and physiological state.
Karine de Mattos +4 more
wiley +1 more source
ELOVL3 regulates phospholipid homeostasis and thermogenesis in brown adipose tissue
Journal of Lipid ResearchNonshivering thermogenesis plays an important role in maintaining body temperature and energy homeostasis. Elongation of very long-chain fatty acid protein 3 (ELOVL3), which catalyzes the synthesis of C20-C24 fatty acids, is induced in brown adipose ...
Zhenbang Qin +7 more
doaj +1 more source
Acta Paediatrica, EarlyView.ABSTRACT Aim Skin‐to‐skin contact stabilizes vital signs, particularly body temperature, in preterm infants. The aim was to determine whether there are differences in body temperature depending on whether preterm infants have skin‐to‐skin contact with their mother or their father.
Johanna Hölzl +3 more
wiley +1 more source
Molecular pathways linking metabolic inflammation and thermogenesis [PDF]
, 2013 Obesity is caused by chronic positive energy balance because of higher energy intake relative to energy expenditure. Thermogenesis, the capacity of an organism to produce heat, is an important component of energy expenditure. Thus targeting the molecular
Solinas, Giovanni
core
Impact of incretin analogues on lipid and lipoprotein metabolism in obesity and diabetes
British Journal of Pharmacology, EarlyView.Abstract Incretin‐based therapies have gained momentum as a key strategy for reducing cardiovascular risk in individuals with obesity and/or type 2 diabetes (T2D). It remains unclear whether the cardiovascular benefits reflect a direct reduction in atherogenic lipoproteins—namely, low‐density lipoproteins (LDL), very low‐density lipoproteins (VLDL) and
Andrea Baragetti, Giuseppe Danilo Norata
wiley +1 more source
Physiological ReportsThe thermogenesis of brown adipose tissue (BAT) is interesting because the contribution to human adaptation to cold and obesity resistance has been suggested.
Yuka Ishida, Kazuhiro Nakayama
doaj +1 more source
British Journal of Pharmacology, EarlyView.Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo +4 more
wiley +1 more source