Results 141 to 150 of about 37,151 (264)

IDH3A Deficiency Compromises Adaptive Thermogenesis and Exacerbates Obesity-Induced Metabolic Dysfunction via Impaired BCKDHA-Dependent BCAA Catabolism. [PDF]

Diabetes
Lu X, Bai N, Lyu J, Sun J, Su Y, Ye Y, Hu T, Liu T, Li W, Li X, Ma X, Yang Y, Bao Y.   +12 more
europepmc   +1 more source

Bandgap‐Engineered PtxTey:Ag2Te Composite Quantum Dots Enable Programmable NIR‐II Imaging and Photothermal‐Immune Synergistic Therapy

Advanced Science, Volume 13, Issue 46, 17 August 2026.
A bandgap‐engineered PtxTey:Ag2Te quantum dot platform enables tunable NIR‐IIb emission for deep‐tissue imaging and mild photothermal therapy. Conjugation with αPD‐L1 confers dual tumor targeting and real‐time monitoring of PD‐L1 dynamics. Mild photothermal modulation induces immune reprogramming, enhancing checkpoint blockade efficacy and achieving ...
Jing Liu, Rui Xu, Quan Wu, Tian‐Xin Xiao, Lai‐Xi Zhao, Lei Sun, Ya‐Wen Zheng, Liang Dong, Zhi‐Quan Tian, Haibo Wang   +9 more
wiley   +1 more source

The Association Between Non-exercise Activity Thermogenesis and Diabetes Status in U.S. Adults: NHANES 2013-2014. [PDF]

Am J Lifestyle Med
Eskildsen KD, Dos Santos H, Medina E, Anjejo D, Beeson WL.   +4 more
europepmc   +1 more source

Dorsal raphe tau pathology disrupts sleep‐wake orchestration and sleep architecture in a sex‐specific manner

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Sleep disturbances are frequent symptoms of Alzheimer's disease (AD), mirrored by early pathology in the dorsal raphe nucleus (DRN). Whether early DRN pathology can drive sleep disturbances, and the relative contributions of serotonin (5‐HT) and sex, has not been directly tested.
Louis J. Kolling, Ruixiang Wang, Gabriel S. Gaudencio, Jamie S. Fishbeyn, Thomas D. James, Suzanne M. Mason, Riley O. McCoy, Zhimin Song, Ian Pascal McConnell, Kylie Ziemke, Kasia M. Janik, Yu Xu, Gabrielle Bierlein‐De La Rosa, Shafa Ismail, Catherine Anne Marcinkiewcz   +14 more
wiley   +1 more source

Improving incretin-mediated body weight loss via energy expenditure. [PDF]

Trends Endocrinol Metab
Elmendorf AJ, Douros JD, Knerr PJ, Flak JN.   +3 more
europepmc   +1 more source

The Postprandial Chronobiome in Interorgan Glucose Homeostasis

Comprehensive Physiology, Volume 16, Issue 4, August 2026.
The postprandial chronobiome framework proposes that meal‐timed oscillations in microbial communities and metabolites may interact with host tissue clocks to shape glucose handling. The liver is the best‐supported temporal interpreter, while phase‐aware human studies are needed to establish causal interorgan effects.
Josko Bozic, Roko Santic, Marko Kumric
wiley   +1 more source

Prenatal stress improves the ability of neonatal lambs to maintain body surface temperature during periods of cold exposure. [PDF]

Int J Biometeorol
Labeur L, Small AH, Schmoelzl S.
europepmc   +1 more source

Chemokine receptor CCR1 restrains adipose tissue remodelling via cAMP/PKA/CREB signalling and adipocyte‒macrophage crosstalk in mice

Clinical and Translational Medicine, Volume 16, Issue 8, August 2026.
CCR1 expression is significantly elevated in adipose tissue of obese individuals. Systemic and adipocyte‐specific Ccr1 deletion promotes fat browning via cAMP/PKA/CREB activation and M2 macrophage polarisation, protecting against obesity. Pharmacological blockade of CCR1 suppresses obesity progression, highlighting its potential as a novel target for ...
Suili Cai, Mengchen Ma, Yuqin Zhu, Mengru Shi, Xiaoyan Dai, Yujie Wang, Mengru Li, Yanwen Yu, Yajiao Wang, Liang Xu   +9 more
wiley   +1 more source

A Structural Context for the Mechanisms of Uncoupling Protein 1 in Brown Fat Thermogenesis. [PDF]

Acta Physiol (Oxf)
Cavalieri R, Dela Rosa MAS, Cotrim CA, Copeman D, Aris M, Eke C, Staggs-Sandy H, Crichton PG.   +7 more
europepmc   +1 more source

Frozen and Scorched: Genomic Signatures of Adaptive Divergence and Hibernation in the Living Fossil Dromiciops

Ecology and Evolution, Volume 16, Issue 8, August 2026.
We evaluated adaptation to torpor and hibernation in the genus Dromiciops by comparing it with both torpid and non‐torpid marsupials, and investigated divergent selection signals between its two species. For the ancestral node, we identified positive selection in the genes PFKFB2, LAMP3, OTX1, and RAPSN, alongside an enrichment of pathways potentially ...
Elisa Gonzalez‐Ugalde, Paula M. Avendaño, Julián F. Quintero‐Galvis, Eduardo J. Pizarro, Francisco A. Cubillos, Roberto F. Nespolo, Fabiola León, Juliana A. Vianna   +7 more
wiley   +1 more source