Results 21 to 30 of about 45,421 (286)

Brown adipocyte and browning thermogenesis: metabolic crosstalk beyond mitochondrial limits and physiological impacts

Adipocyte, 2023
Brown adipocytes were proposed to reverse metabolic conditions such as obesity and diabetes, which make them potential for therapeutic applications.
Van Thi-Tuong Nguyen, Vuong Van Vu, Phuc Van Pham   +2 more
doaj   +1 more source

A subpopulation of Bdnf-e1–expressing glutamatergic neurons in the lateral hypothalamus critical for thermogenesis control

Molecular Metabolism, 2020
Objective: Brown adipose tissue (BAT)–mediated thermogenesis plays a key role in energy homeostasis and the maintenance of body temperature. Previous work suggests that brain-derived neurotrophic factor (BDNF) is involved in BAT thermogenesis, but the ...
He You, Pengcheng Chu, Wei Guo, Bai Lu
doaj   +1 more source

Thermogenesis by THADA [PDF]

Developmental Cell, 2017
THADA has been associated with cold adaptation and diabetes in humans, but the cellular and molecular basis of its function has been unknown. Moraru and colleagues (2017) report in this issue of Developmental Cell that it triggers thermogenesis by uncoupling ATP hydrolysis from calcium transport into the endoplasmic reticulum.
Chatterjee, Nirmalya, Perrimon, Norbert
openaire   +4 more sources

Myeloid p38 activation maintains macrophage–liver crosstalk and BAT thermogenesis through IL‐12–FGF21 axis

Hepatology, EarlyView., 2022
Physiological activation of myeloid p38 controls macrophage IL‐12 production and crosstalk to the liver by modulating hepatic FGF21, and subsequently, brown adipose tissue thermogenesis during obesity Abstract Obesity features excessive fat accumulation in several body tissues and induces a state of chronic low‐grade inflammation that contributes to ...
María Crespo, Ivana Nikolic, Alfonso Mora, Elena Rodríguez, Luis Leiva‐Vega, Aránzazu Pintor‐Chocano, Daniel Horrillo, Lourdes Hernández‐Cosido, Jorge L. Torres, Eva Novoa, Rubén Nogueiras, Gema Medina‐Gómez, Miguel Marcos, Magdalena Leiva, Guadalupe Sabio   +14 more
wiley   +1 more source

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Isoenergetic feeding of low carbohydrate-high fat diets does not increase brown adipose tissue thermogenic capacity in rats [PDF]

, 2012
Low-carbohydrate, high-fat (LC-HF) diets are popular for inducing weight loss in overweighed adults. Adaptive thermogenesis increased by specific effects of macronutrients on energy expenditure has been postulated to induce this weight loss.
Bidlingmaier, Martin, Korbinian Pieper (158350), Müller, H.H., Brigitte Mauracher, William Abplanalp (158346), Marc Slawik (152756), Bidlingmaier, M., Ramisch, Juliane, Mauracher, B., Tschöp Matthias H., Mauracher, Brigitte, Ramisch, J., Bidlingmaier Martin, Pieper, Korbinian, Slawik, Marc, Pieper, K., Juliane Ramisch, Maximilian Bielohuby (158339), Bielohuby Maximilian, Müller Hans-Helge, Matthias H Tschöp, Korbinian Pieper, Tschöp, Matthias H., Matthias J Betz, Matthias J. Betz (158336), Beuschlein, Felix, Abplanalp William, Felix Beuschlein, Matthias H. Tschöp (158357), Abplanalp, William, Pieper Korbinian, Brigitte Mauracher (158342), Beuschlein, F., Hans-Helge Müller (158349), Bielohuby, M., Tschöp, M.H., Bielohuby, Maximilian, Müller, Hans-Helge, William Abplanalp, Mauracher Brigitte, Betz, Matthias J., Marc Slawik, Martin Bidlingmaier (150187), Abplanalp, W., Martin Bidlingmaier, Juliane Ramisch (158353), Betz, M.J., Beuschlein Felix, Slawik, M., Maximilian Bielohuby, Slawik Marc, Ramisch Juliane, Hans-Helge Müller, Felix Beuschlein (158361), Betz Matthias J.   +54 more
core   +1 more source

AMPK in the Ventromedial Nucleus of the Hypothalamus: A Key Regulator for Thermogenesis

Frontiers in Endocrinology, 2020
Obesity has become a global health issue, but effective therapies remain very limited. Adaptive thermogenesis promotes weight loss by dissipating energy in the form of heat, thereby representing a promising target to counteract obesity.
Hailan Liu, Hailan Liu, Yong Xu, Yong Xu, Fang Hu   +4 more
doaj   +1 more source

Transcriptome Profiles of the Liver in Two Cold-Exposed Sheep Breeds Revealed Different Mechanisms and Candidate Genes for Thermogenesis

Genetics Research, 2021
Cold-induced thermogenesis plays an important role in the survival of lambs exposed to low air temperatures. The liver produces and mediates heat production in mammals; however, to date, little is known about the role of liver genes in cold-induced ...
Dan Jiao, Kaixi Ji, Wenqiang Wang, Hu Liu, Jianwei Zhou, A. Allan Degen, Yunsheng Zhang, Ping Zhou, Guo Yang   +8 more
doaj   +1 more source

Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats

Scientific Reports, 2021
The role of central orexin in the sympathetic control of interscapular brown adipose tissue (iBAT) thermogenesis has been established in rodents. Stimulatory doses of caffeine activate orexin positive neurons in the lateral hypothalamus, a region of the ...
L. Van Schaik, C. Kettle, R. Green, W. Sievers, M. W. Hale, H. R. Irving, D. R. Whelan, J. A. Rathner   +7 more
doaj   +1 more source