Results 71 to 80 of about 49,629 (277)

Brown Adipose Tissue: Molecular Mechanisms of Regulation, Physiological Functions, and Therapeutic Targets. [PDF]

MedComm (2020)
This review systematically covers three core dimensions of brown adipose tissue (BAT): multilayered regulatory mechanisms governing brown adipocyte differentiation and phenotypic identity, physiological functions and signaling pathways in mediating thermogenesis and systemic metabolic crosstalk between BAT and multiple organs, and emerging clinical in ...
Deng X, Shen Y, Sun Y, Lu L, Sun C.
europepmc   +2 more sources

Adss1–HDAC3 Interaction: A Novel Mechanism for Epigenetic Regulation of Metabolism in Adipose Tissue

iNew Medicine, EarlyView.
ABSTRACT Obesity and its related metabolic disorders have emerged as global public health challenges with underlying mechanisms involving an imbalance between energy storage and expenditure in the adipose tissue. In recent years, with the deepening research on adipose tissue metabolism, the cross talk between metabolic enzymes and epigenetic regulation
Jiarui Zhao, Jingjing Sun, Yan Lu, Ying Yang   +3 more
wiley   +1 more source

The impact of dietary factors on the function of brown and beige adipose tissues—implications on health and disease

Frontiers in Nutrition
The development of strategies that promote the activation of adaptive thermogenesis in brown and beige adipose tissues is expected to lead to advances in the prevention and treatment of obesity, diabetes, and cardiovascular diseases.
Bruna Bombassaro, Gabriela Batitucci, Marcela Reymond Simoes, Eliana P. Araujo, Eliana P. Araujo, Licio A. Velloso, Licio A. Velloso, Licio A. Velloso   +7 more
doaj   +1 more source

The Enteric Nervous System: An Integrative Hub From Development to Systemic Physiology

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Unlike a static hardwired circuit, the ENS continuously remodels its transcriptional programs and synaptic connectivity in response to three ecological forces: microbial metabolites, immune cell signals and enteroendocrine cues. ABSTRACT The enteric nervous system (ENS) constitutes the largest and most functionally autonomous subdivision of the ...
Mario Cuchillo‐Hilario, Margarita Díaz‐Martínez, Mario Alberto Viazcan‐Carbajal, Victor David González‐Fernández   +3 more
wiley   +1 more source

Advantages of low‐glycaemic‐index carbohydrates in regulating glycaemic response of energy bar: A review

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Energy bars are widely consumed functional foods among athletes and physically active consumers who require convenient sources of sustained energy. Their carbohydrate composition, particularly the type and ratio of digestible sugars such as glucose, fructose and sucrose, strongly influences glycaemic index (GI), postprandial blood glucose ...
Raju Sasikumar, Ayush Gupta, Selva Kumar T, Kaviarasu Ganesan, Sheena Haorongbam, Ravikumar Rajarathinam, Sandeep Janghu, Sandeep Kumar Panda, Amit K. Jaiswal   +8 more
wiley   +1 more source

Proteostasis in thermogenesis and obesity

Biological Chemistry, 2020
AbstractThe proper production, degradation, folding and activity of proteins, proteostasis, is essential for any cellular function. From single cell organisms to humans, selective pressures have led to the evolution of adaptive programs that ensure proteins are properly produced and disposed of when necessary. Environmental factors such as temperature,
Bartelt, A., Widenmaier, S.B.
openaire   +4 more sources

Incretin‐Based Therapies: A Testable Hypothesis Linking Incretin Signaling, Mitochondrial Redox, and OXPHOS Efficiency

Obesity, EarlyView.
ABSTRACT Objective Incretin‐based obesity therapies (IBTs), especially GLP‐1 receptor agonists (GLP‐1 RAs), effectively treat obesity and improve comorbidities. However, their impact on energy metabolism is unclear. A recent case of acute generalized muscle weakness in a patient with mitochondrial myopathy after tirzepatide exposure raises concerns ...
Bryn Falahee, Caroline M. Apovian, Nawfal Istfan   +2 more
wiley   +1 more source

Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, EarlyView., 2023
Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization of biological systems in relation to—and nested within—other biological systems in pregnancy. Pregnancy constitutes a fundamental state for human embodiment and a key step in the evolution and conservation of our species. While not
Anna Ciaunica, Michael Levin, Fernando E. Rosas, Karl Friston   +3 more
wiley   +1 more source

Frequent Versus Single Active Bouts Differentially Affect Movement Behavior and Energy Balance in Adults With Overweight/Obesity

Obesity, EarlyView.
ABSTRACT Objective This study aimed to investigate the effects of breaking up sedentary behavior (SB) on daily movement behavior and energy balance in adults with overweight/obesity. Methods Thirty participants (16F/14M; 34.2 ± 7.3 years; 29.5 ± 3.2 kg/m2) were randomized to either BREAK (multiple 5‐min brisk walking bouts) or a duration‐matched ...
Heloisa C. Santo Andre, Elisa Le Roux, Nathan P. De Jong, Patricia R. Smith, Andrew H. Lange, Carlos Mendez, Alexandre Zahariev, Melissa L. Mamele, Ginger Johnson, Zhaoxing Pan, Chantal Simon, Daniel H. Bessesen, Ana J. Pinto, Audrey Bergouignan   +13 more
wiley   +1 more source

Octopamine drives honeybee thermogenesis

, 2022
In times of environmental change species have two options to survive: they either relocate to a new habitat or they adapt to the altered environment. Adaptation requires physiological plasticity and provides a selection benefit.
Engelmayer, Lorenz, Bayer, Jasmin, Lorenz Engelmayer, Seifert, Roland, Scherf-Clavel, Oliver, Heike Bähre, Thamm, Markus, Jasmin Bayer, Kaya-Zeeb, Sinan, Bähre, Heike, Mara Straßburger, Straßburger, Mara, Oliver Scherf-Clavel, Sinan Kaya-Zeeb, Roland Seifert, Markus Thamm   +15 more
core   +1 more source