Results 201 to 210 of about 49,629 (277)

Single‐Cell Multiomics Reveals That OTUD7B Is a Central Driver of Epithelial Remodelling and the Immunosuppressive Microenvironment in Pancreatic Ductal Adenocarcinoma

Journal of Cellular and Molecular Medicine, Volume 30, Issue 19, October 2026.
ABSTRACT Pancreatic ductal adenocarcinoma (PAAD) is characterized by extreme malignancy and profound resistance to therapy, largely driven by a fibrotic and immunosuppressive tumour microenvironment (TME). The deubiquitinase OTU domain‐containing protein 7B (OTUD7B) has been implicated in inflammatory and oncogenic signalling, but its role in PAAD and ...
Xiao‐Li Liu, Jing‐Wang, Shan‐Yu Zhao, Lu‐Li, Ming‐Hui Zhang   +4 more
wiley   +1 more source

Brown adipose tissue in ruminants: development, thermogenic function, and nutritional regulation. [PDF]

Front Vet Sci
Xiao ZH, Duan HW, Li L.
europepmc   +1 more source

Prolactin receptor signalling contributes to the attenuation of stress‐induced hyperthermia during pregnancy

Journal of Neuroendocrinology, Volume 38, Issue 10, October 2026.
Abstract During pregnancy, thermoregulation is tightly controlled to protect the foetus from harmful elevated temperatures. Stress‐induced hyperthermia is a component of the stress response that increases alertness to a perceived threat. Previous literature has shown that like other aspects of the stress response, stress‐induced hyperthermia is ...
Andrew M. Stewart, David R. Grattan, Teodora R. Georgescu   +2 more
wiley   +1 more source

Phytochemicals and Irisin as Multi-Target Regulators of Adipose Tissue Browning and Metabolic Reprogramming: Synergies with GLP-1 Pathways. [PDF]

Antioxidants (Basel)
Ulusu NN.
europepmc   +1 more source

METTL18 is Required for Developmental, Metabolic, and Endocrine Regulation of Mammalian Growth

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
METTL18 is essential for histidine Nτ‐methylation of proteins, normal embryonic development, iron and lipid metabolism, and hormone signaling pathways that support postnatal growth in mice. The main points of this study are as follows: First, mouse METTL18 catalyzes histidine Nτ‐methylation. Next, Mettl18 KO embryos are significantly smaller than their
Fumiya Kasai, Jun‐Dal Kim, Koichiro Kako, Naoto Muromachi, Takeru Saito, Yao Yuan, Hayase Mizukami, Nana Kishikawa, Kanako Nakamura, Kaori Motomura, Hiroaki Daitoku, Yuuki Imai, Sho Sekiguchi, Kazuhiko Horiguchi, Satoshi Narumi, Masanobu Yamada, Akiyoshi Fukamizu   +16 more
wiley   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity. [PDF]

Adv Sci (Weinh)
Li TT, Zhao XY, Zhang M, Weng ZF, Guo XR, Liu YF, Wang QP, Liang HH.   +7 more
europepmc   +1 more source

Forsythoside A Attenuates High-Fat Diet-Induced Obesity by Regulating Thermogenesis and Browning of White Adipose Tissue Through Activation of the AMPK Signaling Pathway. [PDF]

Pharmaceuticals (Basel)
Meng Q, Xu H, Zhong M, Mu Y, Zhao X, Lin C, Xu F, Yang M, Sun H, Xu Y, Li Y.   +10 more
europepmc   +1 more source

Advances in research on thermogenic substances. [PDF]

J Physiol Anthropol
Tao M, Gao Y, Chai X, Peng J, Guo C, Yu L, Yao Z.   +6 more
europepmc   +1 more source

Macrophage-derived itaconate is a negative regulator of adipose tissue thermogenesis. [PDF]

Nat Metab
Tang J, Pernes G, Nakagaki B, Tran N, Bokor L, Prenen F, Yi M, Robertson AE, Cronin R, Sarmini M, Pierscianowski J, Roberts V, Ryback BA, Novina CD, Auclair K, Xiao H, Mills EL.   +16 more
europepmc   +1 more source