Results 41 to 50 of about 1,873 (179)
Engineering vanilloid-sensitivity into the rat TRPV2 channel
eLife, 2016 The TRPV1 channel is a detector of noxious stimuli, including heat, acidosis, vanilloid compounds and lipids. The gating mechanisms of the related TRPV2 channel are poorly understood because selective high affinity ligands are not available, and the ...
Feng Zhang +8 more
doaj +1 more source
The adaptive evolution of cold‐activated TRPM8 in wildlife vertebrates 野生脊椎动物TRPM8冷激活的适应性进化
Wildlife Letters, Volume 1, Issue 1, Page 23-31, March 2023., 2023 The functional evolution of TRPM8 cold activation underwent a two‐step model: (1) the cold‐sensitive MHR1‐3 domain located in N‐terminus established during water‐to‐land transition, which bestowed TRPM8 orthologs in amphibians and reptiles with cold‐ sensing ability; (2) Based on the evolved MHR1‐3 domain, more advanced terrestrial vertebrates further ...
Xiancui Lu +6 more
wiley +1 more source
Foods, 2018 The International Agency for Research on Cancer (IARC) evaluates “very hot (>65 °C) beverages” as probably carcinogenic to humans. However, there is a lack of research regarding what temperatures consumers actually perceive as &ldquo ...
Julia Dirler +2 more
doaj +1 more source
Crystals, 2021 Photoluminescent liquid crystals (PLLCs) have attracted significant attention owing to their broad applicability in thermosensing and PL switching.
Shigeyuki Yamada +10 more
doaj +1 more source
Optical Nanofiber Skins for Multifunctional Humanoid Tactility
Advanced Intelligent Systems, Volume 5, Issue 2, February 2023., 2023 By embedding the optical nanofibers (ONF) into elastomeric films, multimodal artificial skins that can respond to temperature and force stimuli are achieved. Special modules are further assembled on the ONF skins to recognize material properties including hardness, texture, and thermal conductivity. Commercial robots equipped with the ONF skins perform
Yao Tang +9 more
wiley +1 more source
Injury Threshold of Oral Contact with Hot Foods and Method for Its Sensory Evaluation
Safety, 2018 Epidemiological studies indicate an increased risk of esophageal cancer from the consumption of very hot foods and beverages. The contact time and the contact temperature are decisive for the risk of injury.
Dirk W. Lachenmeier, Walter Lachenmeier
doaj +1 more source
Evidence that the TRPV1 S1-S4 membrane domain contributes to thermosensing
Nature Communications, 2020 The TRPV1 ion channel is a heat-sensing receptor that is also activated by vanilloid compounds, but the molecular underpinnings of thermosensing have remained elusive.
Minjoo Kim +7 more
doaj +1 more source
RNA thermosensors facilitate Streptococcus pneumoniae and Haemophilus influenzae immune evasion.
PLoS Pathogens, 2021 Bacterial meningitis is a major cause of death and disability in children worldwide. Two human restricted respiratory pathogens, Streptococcus pneumoniae and Haemophilus influenzae, are the major causative agents of bacterial meningitis, attributing to ...
Hannes Eichner +6 more
doaj +1 more source
mBio, 2019 Environmental awareness is an essential attribute of all organisms. The homeoviscous adaptation system of Bacillus subtilis provides a powerful experimental model for the investigation of stimulus detection and signaling mechanisms at the molecular level.
Pilar Fernández +6 more
doaj +1 more source
Crystal structure of a thermophilic GrpE protein: insight into thermosensing function for the DnaK chaperone system. [PDF]
, 2010 A homodimeric GrpE protein functions as a nucleotide exchange factor of the eubacterium DnaK molecular chaperone system. The co-chaperone GrpE accelerates ADP dissociation from, and promotes ATP binding to, DnaK, which cooperatively facilitates the DnaK ...
Miki, Kunio +2 more
core +1 more source