Results 71 to 80 of about 1,415 (167)

SUPER: Upcycling Genetic Parts for Precise Gene Expression Control, Leakage Minimization, and Genetic Circuit Stability

open access: yesAdvanced Science, Volume 13, Issue 12, 27 February 2026.
To precisely modulate natural and synthetic regulatory parts, SUPER is introduced as a sophisticated and tunable controller of genetic devices without requiring sequence modification on the target. SUPER enhances dynamic range of RNA‐, chemical‐, temperature‐, and protein‐responsive biosensors up to 1011%, and converts biosensors to cover an expanded ...
Taeyang Heo   +3 more
wiley   +1 more source

Traceless Regulation of Genetic Circuitry

open access: yesAdvanced Science, Volume 13, Issue 10, 18 February 2026.
Energy‐based, as opposed to molecular, control offers unprecedented improvements in key circuit parameters. This review summarizes the fundamentals of such traceless switches, categorizes them by trigger modalities, and compares and contrasts distinct advantages as well as shortcomings of each kind.
Gokberk Unal, Martin Fussenegger
wiley   +1 more source

Structure and Function of the Escherichia coli Thermosensors.

open access: yesSeibutsu Butsuri, 1999
Thermotaxis in Escherichia coli as a model system for studying thermosensing mechanisms. All the components involved in the signal transduction circuit have been indentified. Thermosensors are the transmembrane proteins that were originally indentified as chemoreceptors. They regulate the activity of the cytoplasmic histidine kinase CheA.
NISHIYAMA, So-ichiro   +2 more
openaire   +1 more source

Solid-like condensation of MORF8 inhibits RNA editing under heat stress in Arabidopsis

open access: yesNature Communications
Heat stress inhibits photosynthesis efficiency, thereby suppressing plant growth and crop yield. However, the mechanism underlying this inhibition is not fully understood.
Jie Wu   +5 more
doaj   +1 more source

Change in intraoperative rectal temperature influencing erectile dysfunction following transurethral resection of the prostate

open access: yesJournal of the Formosan Medical Association, 2012
In this study, we assessed the relationship between changes in intraoperative rectal temperature and erectile function in patients who have undergone transurethral resection of the prostate.
Chih-Kuang Liu   +7 more
doaj   +1 more source

Photobody formation spatially segregates two opposing phytochrome B signaling actions of PIF5 degradation and stabilization

open access: yesNature Communications
Photoactivation of the plant photoreceptor and thermosensor phytochrome B (PHYB) triggers its condensation into subnuclear membraneless organelles named photobodies (PBs). However, the function of PBs in PHYB signaling remains frustratingly elusive. Here,
Ruth Jean Ae Kim   +5 more
doaj   +1 more source

Distinguishing individual photobodies using Oligopaints reveals thermo-sensitive and -insensitive phytochrome B condensation at distinct subnuclear locations

open access: yesNature Communications
Photobodies (PBs) are membraneless subnuclear organelles that self-assemble via concentration-dependent liquid-liquid phase separation (LLPS) of the plant photoreceptor and thermosensor phytochrome B (PHYB).
Juan Du, Keunhwa Kim, Meng Chen
doaj   +1 more source

Histone lactylation regulates DOCK4 to control heat nociception and supports Dynein-mediated Nav1.7 trafficking

open access: yesNature Communications
Heat nociception involves thermosensors like transient receptor potential channel V1 in dorsal root ganglion (DRG) neurons, but their loss only partially impairs heat sensing, suggesting other mechanisms.
Man-Xiu Xie   +12 more
doaj   +1 more source

Integrative signaling networks of membrane guanylate cyclases: Biochemistry and physiology

open access: yesFrontiers in Molecular Neuroscience, 2016
This monograph presents a historical perspective of cornerstone developments on the biochemistry and physiology of mammalian membrane guanylate cyclases (MGCs), highlighting contributions made by the authors and their collaborators.
Rameshwar K Sharma   +2 more
doaj   +1 more source

Transmembrane Prolines Mediate Signal Sensing and Decoding in Bacillus subtilis DesK Histidine Kinase

open access: yesmBio, 2019
Environmental awareness is an essential attribute of all organisms. The homeoviscous adaptation system of Bacillus subtilis provides a powerful experimental model for the investigation of stimulus detection and signaling mechanisms at the molecular level.
Pilar Fernández   +6 more
doaj   +1 more source

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