Results 151 to 160 of about 55,424 (301)

Engineered surface strategies to manage dental implant‐related infections

Periodontology 2000, EarlyView.
Abstract When exposed to the oral environment, dental implants, like natural surfaces, become substrates for microbial adhesion and accumulation, often leading to implant‐related infections—one of the main causes of implant failure. These failures impose significant costs on patients, clinicians, and healthcare systems.
João Gabriel S. Souza, Bruna E. Nagay, Rodrigo Martins, Martinna Bertolini, Jamil A. Shibli, Conrado Aparicio, Magda Feres, Valentim A. R. Barão   +7 more
wiley   +1 more source

Putative involvement of lncRNA, miRNA, and mRNA‐mediated ceRNA network regulation in drought priming to enhance drought tolerance in Nicotiana tabacum

Annals of Applied Biology, Volume 189, Issue 1, July 2026.
Drought priming increased the tolerance of Nicotiana tabacum to severe, recurring drought stress by modulating the expression of stress‐related genes via long non‐coding RNAs (lncRNAs), which acted as competing endogenous RNAs (ceRNAs) for microRNAs (miRNAs) and messenger RNAs (mRNAs).
Fatma Aydinoglu, Elif Yalvac
wiley   +1 more source

Identification of thermostability-enhancing mutations in H9N2 avian influenza virus hemagglutinin. [PDF]

J Virol
Liu B, Yu H, Yan Z, Zou S, Guo J, Cai S, Hu Y, Yang Y, Yan Y, Liu H, Mei K, Li Z, Qin L, Li Y, Huang S, Wen F.   +15 more
europepmc   +1 more source

Targeting Middle East Respiratory Syndrome Coronavirus Spike Fusion Machinery With Antiviral Peptides: In Silico Exploration of the Heptad Repeat 2 Domain

MicrobiologyOpen, Volume 15, Issue 3, June 2026.
Griffithsin, Brevinin‐2, and CCL20 were identified as potent MERS‐CoV fusion inhibitor candidates targeting the HR2 domain through integrated molecular docking, MD simulations, and MM/PBSA analyses. These peptides demonstrated superior binding stability and favorable safety profiles compared to the standard inhibitor, supporting their potential as ...
Nasser Alotaiq, Doni Dermawan, Samir Chtita   +2 more
wiley   +1 more source

Computational Design of a Thermo-Acidostable Endo-Polygalacturonase for Efficient Juice Extraction. [PDF]

Foods
Cheng Z, Hou G, Zhang T, Feng D, Zhang Y, Wang X, Yang L, Luo M, Pan L.   +8 more
europepmc   +1 more source

Detection of protein symmetry and structural rearrangements using secondary structure elements

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Many proteins exhibit a degree of internal symmetry in their tertiary structure, including circular permutations. These characteristics play an important role in terms of the functional robustness of proteins against mutations, and are pivotal for the study of protein function and evolution.
Runfeng Lin, Sebastian E. Ahnert
wiley   +1 more source

Deep learning-guided dual-fitness evolution of T7 RNA polymerase for enhanced stability and activity. [PDF]

Nucleic Acids Res
Jiang F, Kang L, Li M, Zhong B, Chen X, Wu B, Li M, Yu Y, Hong L.   +8 more
europepmc   +1 more source

Stability and cooperativity in chimeric de novo TIM barrels via quarter swapping

Protein Science, Volume 35, Issue 6, June 2026.
Abstract The use of repetitive units as building blocks in protein design, mimicking evolutionary duplication events, is a valuable strategy that reduces structural complexity. Such modular designs offer an opportunity to dissect how local contributions are integrated in a context‐dependent manner.
Oscar Rodríguez‐Meza, Isabel Velázquez‐López, A. Jessica Díaz‐Salazar, Sergio Romero‐Romero, Miguel Costas, D. Alejandro Fernández‐Velasco   +5 more
wiley   +1 more source

Thermostability engineering of microbial transglutaminase using artificial intelligence and investigation of its underlying mechanisms. [PDF]

Bioresour Bioprocess
Song X, Han K, Xu P, Zheng J, Cai J.
europepmc   +1 more source

Backbone double‐mutant cycle analysis quantifies hydrogen‐bond energies in proteins

Protein Science, Volume 35, Issue 6, June 2026.
Abstract Protein structure is stabilized by a variety of noncovalent interactions, but many remain incompletely understood. For example, several potentially ubiquitous interactions involving the protein backbone have been identified, but challenges in determining reliable experimental energies have prevented their integration into structural models. To
Haoliang Zheng, Robert W. Newberry
wiley   +1 more source