Results 91 to 100 of about 131,236 (370)

Investigation of a broad‐spectrum micronutrient formulation as a possible precipitant of pharmacokinetic micronutrient–drug interactions

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Daily broad‐spectrum micronutrients are being used by the general public and formulations are receiving research interest in mental health settings. Despite concerns about combining medicines and broad‐spectrum micronutrients in mental health care, there have not been any formal evaluations of potential interactions.
Bess M. Kew   +7 more
wiley   +1 more source

Erythrocyte transketolase activity coefficient (ETKAC) assay protocol for the assessment of thiamine status

open access: yesAnnals of the New York Academy of Sciences, 2020
Vitamin B1 (thiamine) is an essential nutrient that acts as a cofactor for a number of metabolic processes, particularly in energy metabolism. Symptoms of classic thiamine deficiency are recognized as beriberi, although clinical symptoms are nonspecific ...
K. Jones   +3 more
semanticscholar   +1 more source

Aspects of the quantitative separation and estimation of thiamine and its phosphate esters : a thesis presented in partial fulfilment of the requirements for the degree of Master of Science in Biochemistry at Massey University [PDF]

open access: yes, 1981
Methods for the separation and estimation of thiamine, thiamine monophosphate and thiamine diphosphate which would be applicable to biological extracts were investigated.
Scott, Paul Noel
core  

Mechanismus der enzymatischen Freisetzung von Acetaldehyd aus “aktivem Acetaldehyd” (α-hydroxyaethyl-2-thiaminpyrophosphat) [PDF]

open access: yes, 1961
1. 1.Die Freisetzung von Acetaldehyd aus “Aktivem Acetaldehyd” mit gereinigter Apopyruvatdecarboxylase aus Bierhefe wird durch. Thiaminpyrophosphat gehemmt.
Breslow   +13 more
core   +1 more source

Sigma Factors as Potential Targets to Enhance Recombinant Protein Expression

open access: yesBiotechnology and Bioengineering, EarlyView.
ABSTRACT The transcriptional factors control the expression of many genes and represent an important layer of complexity in cell factories. However, the effect of individual sigma factor deletions from a biomanufacturing perspective has not been addressed. In this contribution, growth, green fluorescence protein (GFP) expression, and oxygen consumption
Laura Pohlen   +6 more
wiley   +1 more source

Randomized, Double-Blind, Placebo-Controlled Trial of Thiamine as a Metabolic Resuscitator in Septic Shock: A Pilot Study

open access: yesCritical Care Medicine, 2016
Objective:To determine if intravenous thiamine would reduce lactate in patients with septic shock. Design:Randomized, double-blind, placebo-controlled trial. Setting:Two US hospitals.
M. Donnino   +10 more
semanticscholar   +1 more source

Thiamine-responsive acute severe pulmonary hypertension in exclusively breastfeeding infants: a prospective observational study

open access: yesArchives of Disease in Childhood, 2020
Objectives Severe pulmonary hypertension (PH) causing right heart failure can occur due to thiamine deficiency in exclusively breastfeeding infants.
Usha M K Sastry   +8 more
semanticscholar   +1 more source

Designing Enzymatic Reactivity with an Expanded Palette

open access: yesChemBioChem, EarlyView.
Innovation in biocatalysis is rapidly increasingly the diversity of catalytic reactivity that can be mediated by enzymes, addressing a key bottleneck for their widespread adoption in industrial chemical synthesis. A key approach to this is building enzymes with unnatural catalytic components that provide an expanded palette with new possibilities for ...
Reuben B. Leveson‐Gower
wiley   +1 more source

Ascorbic acid, corticosteroids, and thiamine in sepsis: a review of the biologic rationale and the present state of clinical evaluation

open access: yesCritical Care, 2018
The combination of thiamine, ascorbic acid, and hydrocortisone has recently emerged as a potential adjunctive therapy to antibiotics, infectious source control, and supportive care for patients with sepsis and septic shock.
A. Moskowitz   +13 more
semanticscholar   +1 more source

Wernicke’s encephalopathy — from basic science to clinical practice. Part 1: Understanding the role of thiamine

open access: yesTherapeutic Advances in Psychopharmacology, 2020
Wernicke’s encephalopathy (WE) is an acute neuropsychiatric state. Untreated, WE can lead to coma or death, or progress to Korsakoff syndrome (KS) – a dementia characterized by irreversible loss of anterograde memory.
M. Ott, U. Werneke
semanticscholar   +1 more source

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