Results 131 to 140 of about 131,236 (370)

Thiamine Metabolites and Dementia? [PDF]

EBioMedicine, 2016
The determinants of amyloid deposition in the brain, increased intracerebral phosphorylated tau, hippocampal atrophy, and loss of synapses in areas of brain (the pathogenic determinants of most dementia) remain undetermined except for Mendelian genetic disorders and higher risk of both amyloid deposition and dementia among individuals who carry the ...
openaire   +4 more sources

Multi‐cycle high‐throughput growth media optimization using batch Bayesian optimization

Journal of Chemical Technology &Biotechnology, EarlyView.
Abstract BACKGROUND The optimization of growth media is a crucial step in enhancing microbial growth and product formation in industrial bioprocesses. While Design of Experiments (DoE) is widely used for this purpose, it has inherent limitations, particularly in capturing complex interactions between media components and managing the high number of ...
Frédéric M. Lapierre, Pasquale Mattaliano, Dennis Raith, Mariela Castillo‐Cota, Jonas Bermeitinger, Robert Huber   +5 more
wiley   +1 more source

GmPGL1, a Thiamine Thiazole Synthase, Is Required for the Biosynthesis of Thiamine in Soybean

Frontiers in Plant Science, 2019
Thiamine is an essential cofactor in several enzymatic reactions for all living organisms. Animals cannot synthesize thiamine and depend on their diet.
Xingxing Feng, Xingxing Feng, Suxin Yang, Kuanqiang Tang, Kuanqiang Tang, Yaohua Zhang, Jiantian Leng, Jingjing Ma, Jingjing Ma, Quan Wang, Quan Wang, Xianzhong Feng   +11 more
doaj   +1 more source

“The future”: Interpretative phenomenological analysis of general practitioners' experiences of co‐employed clinical psychologists

Journal of General and Family Medicine, EarlyView.
Abstract Background General practice is overwhelmed and understaffed. New models and modalities must be considered from the front door of healthcare. Like general practitioners (GPs), clinical psychologists are qualified to work across the age range and transdiagnostically. Aim To explore GPs' understanding of the role of a clinical psychologist and to
Katie Monnickendam, Peter Keohane, Rebecca Magill   +2 more
wiley   +1 more source

The endogenous Coxiella burnetii plasmid encodes a functional toxin–antitoxin system

Molecular Microbiology, Volume 118, Issue 6, Page 744-764, December 2022., 2022
Coxiella burnetii is an obligate intracellular bacterium and causative agent of Q fever. Here we report that the C. burnetii genome encodes 11 toxin–antitoxin systems, which is highly unusual for intracellular bacteria, and that one TA system is encoded on the large endogenous plasmid found in almost all C. burnetii isolates.
Shaun Wachter, Diane C. Cockrell, Heather E. Miller, Kimmo Virtaneva, Kishore Kanakabandi, Benjamin Darwitz, Robert A. Heinzen, Paul A. Beare   +7 more
wiley   +1 more source

Pharmacokinetics of high-dose oral thiamine hydrochloride in healthy subjects [PDF]

, 2012
Background: High dose oral thiamine may have a role in treating diabetes, heart failure, and hypermetabolic states. The purpose of this study was to determine the pharmacokinetic profile of oral thiamine hydrochloride at 100 mg, 500 mg and 1500 mg doses ...
A Alkhalaf, A Greb, AB Morrison, AD Thomson, AD Thomson, AD Thomson, AD Thomson, AD Thomson, AM Hoyumpa, AM Hoyumpa, AM Hoyumpa, AM Hoyumpa, C Barnerias, CME Tallaksen, David J Greenblatt, E Beltramo, E Beltramo, E Berrone, E Hartung, H Stracke, H Stracke, Howard A Smithline, JP Blass, K Meador, KA Nolan, KD Wrenn, M Baines, M Donnino, M Zielinska-Dawidziak, Michael Donnino, MJ Royer-Morrot, ML Volvert, MW Donnino, N Karachalias, N Karachalias, P Balakumar, PJ Thornalley, R Babaei-Jadidi, R Davis, RC Young, SK Wolfson, T Frank, V Soukoulis, W Weber   +43 more
core   +2 more sources

Association between early phosphate intake and refeeding syndrome in extremely low‐birth‐weight infants: A retrospective cohort study

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract Background Preterm infants are at risk of refeeding syndrome, a constellation of biochemical changes associated with nutrition. We aimed to determine whether increased early phosphate intake with routine biochemical monitoring is associated with a reduction in refeeding syndrome.
Thomas B. Wright, Frank H. Bloomfield, Tanith Alexander, Barbara E. Cormack   +3 more
wiley   +1 more source

Molecular mechanisms of the non-coenzyme action of thiamin in brain. Biochemical, structural and pathway analysis [PDF]

, 2015
Thiamin (vitamin B1) is a pharmacological agent boosting central metabolism through the action of the coenzyme thiamin diphosphate (ThDP). However, positive effects, including improved cognition, of high thiamin doses in neurodegeneration may be ...
Andrey, Vovk, Contestabile, Roberto, DI SALVO, Martino Luigi, Garik, Mkrtchyan, Lucien, Bettendorff, Parroni, Alessia, Thilo, Kaehne, Vasily, Aleshin, Victoria, Bunik, Yulia, Parkhomenko   +9 more
core   +1 more source

Evidence and unknowns for the relevancy of applying current parenteral nutrition support recommendations among infants born less than 750 g or younger than 25 weeks' gestation: A narrative review

Journal of Parenteral and Enteral Nutrition, EarlyView.
Abstract With advancements in neonatal care, the viability of extremely low‐birth‐weight (ELBW) infants, especially those born extremely preterm, is increasing. However, specific recommendations for managing parenteral nutrition (PN) support in nanopreterm infants (<750 g or <25 weeks' gestation) are lacking.
Mar Romero‐Lopez, Mamta Naik, Teresa Hartman, Ann Anderson‐Berry, Melissa Thoene   +4 more
wiley   +1 more source

Pathway Editing Targets for Thiamine Biofortification in Rice Grains

Frontiers in Plant Science, 2018
Thiamine deficiency is common in populations consuming polished rice as a major source of carbohydrates. Thiamine is required to synthesize thiamine pyrophosphate (TPP), an essential cofactor of enzymes of central metabolism. Its biosynthesis pathway has
Anu P. Minhas, Rakesh Tuli, Sanjeev Puri
doaj   +1 more source