Results 131 to 140 of about 70,377 (295)

Thiamine, thiamine phosphates and thiamine metabolizing enzymes in synaptosomes of rat brain.

, 1990
Thiamine and thiamine mono-, pyro- and triphosphate were found at detectable levels in synaptosomes isolated from whole rat brain. Synaptosomes prepared from whole brain, cerebellum and medulla were also found to contain uridine and inosine mono- and ...
POLONI M, MAZZARELLO, PAOLO ANGELO, RINDI, GIANGUIDO, PATRINI, CESARE, LAFORENZA, UMBERTO   +4 more
core  

Thiamine uptake in human intestinal biopsy specimens, including observations from a patient with acute thiamine deficiency. [PDF]

, 1997
Mucosal biopsy specimens obtained by routine endoscopy from 108 human subjects, including one patient with thiamine deficiency, were incubated at 37 degrees C in oxygenated calcium-free Krebs-Ringer solution (pH 7.5) containing tritiated thiamine and ...
ALVISI C, RINDI, GIANGUIDO, PATRINI, CESARE, FAELLI A, LAFORENZA, UMBERTO, LICANDRO A   +5 more
core  

Thiamine supplementation increases serum thiamine and reduces pyruvate and lactate levels in burn patients

, 2010
The importance of vitamins for optimal metabolism is well established. However, currently little is known about the optimal vitamin levels required for burn patients.
Rea, Suzanne, Phillips, Michael, Gurfinkel, Reuven, Falder, Sian, Wood, Fiona M, Silla, Robyn, Bartley, Anthony, Baur, Esther, Fear, Mark W   +8 more
core   +1 more source

Dystrophia Smolandiensis is characterized by a novel NQO1 variant and a distinct phenotype from COL17A1‐associated epithelial recurrent erosion dystrophy

Acta Ophthalmologica, EarlyView.
Abstract Purpose To determine the molecular cause of the two epithelial recurrent erosion dystrophies, Dystrophia Smolandiensis and Dystrophia Helsinglandica, and to identify phenotypic differences between the two conditions. Methods DNA samples and clinical data from structured interview records were obtained from the Swedish families in which ...
Karl De Geer, Kristina Lagerstedt‐Robinson, Daniel Nilsson, Cilla Söderhäll, Björn Hammar, Erik Björck   +5 more
wiley   +1 more source

Thiamine use is associated with better outcomes for traumatic brain injury patients

Frontiers in Nutrition
BackgroundTraumatic brain injury (TBI) is a global health concern that often leads to poor prognosis. We designed this study to explore whether thiamine use is associated with a better prognosis of TBI.MethodsTBI patients selected from the Medical ...
Ruoran Wang, Yunhui Zeng, Jianguo Xu, Min He   +3 more
doaj   +1 more source

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

British Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco, Patrick Harrington, Elena Torre, Hillary Catellani, Novella Pugliese, Matteo Pacilli, Annalisa Santisi, Arianna Sbriglione, Giuseppe A. Palumbo   +8 more
wiley   +1 more source

Consensus Guidelines for Diagnosis and Management of Pyruvate Dehydrogenase Complex Deficiency. [PDF]

J Inherit Metab Dis
ABSTRACT Primary pyruvate dehydrogenase complex deficiency (PDCD) comprises a group of monogenic disorders caused by pathogenic variants in genes encoding subunits of, or regulatory components affecting, the pyruvate dehydrogenase complex. The clinical phenotype spans a broad continuum, ranging from early onset congenital lactic acidosis to infantile ...
Keshavan N, Neugebauer J, Bellusci M, Bertini E, Brown G, Darin N, DeBrosse S, Drexler L, Drexler S, Enns GM, Ganetzky RD, Gilbert K, Larson A, Legi R, Lehman AN, Newby C, Schiff M, Skeath R, Stacpoole PW, Thompson S, Watt E, Wortmann SB, Bedoyan JK, Rahman S.   +23 more
europepmc   +2 more sources

Metabolic remodelling in anthracycline cardiotoxicity: mechanisms and therapeutic insights

British Journal of Pharmacology, EarlyView.
Cardiac metabolic remodelling in anthracycline‐induced cardiomyopathy and metabolically oriented cardioprotective strategies. Schematic representation of substrate utilization, mitochondrial bioenergetic function and metabolic flexibility in the healthy heart, in anthracycline‐induced cardiomyopathy and under potential cardioprotective interventions ...
Giulia Guerra, Francesco Niro, Marco Mergiotti, Giovanni Gavatorta, Emilio Hirsch, Alessandra Ghigo   +5 more
wiley   +1 more source

Using Role Substitution to Improve Oral Health of Dependent Older People Residing in Care Homes and Assisted Living Settings in the United Kingdom

Community Dentistry and Oral Epidemiology, EarlyView.
ABSTRACT Objectives To determine whether Dental Therapists and Dental Nurses could reduce plaque levels of dependent older adults residing in care homes and assisted living settings, when compared to ‘treatment as usual’. Methods A two‐arm pragmatic cluster randomised controlled trial over a 6‐month period was undertaken based on an a priori assumption
Paul R. Brocklehurst, Gerry McKenna, Zoe Hoare, Alison Jenkins, Rachel Evans, Saif Sayeed Syed, Michelle Harvey, Ivor G. Chestnutt, Sarah R. Baker, Craig J. Smith, Ciaran O'Neill, Annie Hendry, Anup Karki, Kirstie Moons, Fiona Sandom, Michael Donaldson, Caroline Lappin, Karen Shepherd, Lorraine Morgan, Georgios Tsakos   +19 more
wiley   +1 more source

Substrate transport and drug interaction of human thiamine transporters SLC19A2/A3

Nature Communications
Thiamine and pyridoxine are essential B vitamins that serve as enzymatic cofactors in energy metabolism, protein and nucleic acid biosynthesis, and neurotransmitter production.
Peipei Li, Zhini Zhu, Yong Wang, Xuyuan Zhang, Chuanhui Yang, Yalan Zhu, Zixuan Zhou, Yulin Chao, Yonghui Long, Yina Gao, Songqing Liu, Liguo Zhang, Pu Gao, Qianhui Qu   +13 more
doaj   +1 more source