British Journal of Clinical Pharmacology, Volume 92, Issue 6, Page 1787-1808, June 2026.Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale +5 more
wiley +1 more source
Thiamine and Micronutrient Deficiencies in Hospitalized Veterans Without Alcohol Use Disorder. [PDF]
DiseasesMates EA +4 more
europepmc +1 more source
Severe Restriction of Glucose Import Enhances Recombinant Protein Production in Escherichia coli
Biotechnology Journal, Volume 21, Issue 6, June 2026.Graphical Abstract and Lay Summary Producing recombinant proteins in Escherichia coli is often limited by the bacterium's tendency to consume glucose too rapidly. This excessive glucose uptake causes overflow metabolism, leading to the accumulation of acetate, a byproduct that can reduce cellular performance and protein production.
Juan Carlos Fragoso‐Jiménez +5 more
wiley +1 more source
Rethinking Thiamine in the Emergency Department: Why a Hi-Phy-Vi-Based "Suspect and Treat" Approach Matters in an Aging Society. [PDF]
CureusSakamoto S.
europepmc +1 more source
Genetically Programmed Control of Overflow Metabolism
Biotechnology and Bioengineering, Volume 123, Issue 6, Page 1624-1633, June 2026.ABSTRACT Overflow metabolism is a highly undesirable phenomenon that occurs in virtually all cell factories. Although several schemes have been applied to avoid overflow metabolism, this problem remains far from being solved. In this study, a genetic sensor for detecting overflow metabolism was designed, and its substrate specificity and reversibility ...
Lærke M. Jensen +3 more
wiley +1 more source
Bulletin of the Korean Chemical Society, Volume 47, Issue 6, Page 745-755, June 2026.Vitamins could regulate both MMP‐2 and MMP‐9 expression and activity through transcriptional and MAPK signaling pathway modulation. This study highlights the potential of vitamins as low‐toxicity therapeutic or adjunct agents for targeting MMP‐mediated cancer progression. Abstract Matrix metalloproteinases (MMP‐2 and MMP‐9) are key regulators of cancer
Yen Thi Nguyen +5 more
wiley +1 more source
Severe Hypokalemia Complicated by Wernicke's Encephalopathy and Hypoxic-Ischemic Brain Injury in Pregnancy: A Case from a Resource-Limited ICU. [PDF]
Int Med Case Rep JTahajud OA, Elmi AH, Ahmed OH, Ali HA.
europepmc +1 more source
Severe Lactic Acidosis in Decompensated Cirrhosis Despite Nondiagnostic Imaging
Clinical Case Reports, Volume 14, Issue 6, June 2026.ABSTRACT Lactic acidosis is a strong predictor of mortality in cirrhosis, reflecting both impaired hepatic clearance and systemic tissue hypoxia. We describe a 38‐year‐old man with decompensated alcohol‐associated cirrhosis who developed severe lactic acidosis despite stable hemodynamics and initially nondiagnostic vascular imaging.
Nakul Ganju +5 more
wiley +1 more source
Wernicke-Korsakoff Syndrome a Rare Complication of Hyperemesis Gravidarum: Case Report. [PDF]
Clin Case RepNeupane A, Shahi A, Adhikari B.
europepmc +1 more source
Bioenhancer‐Driven Modulation of Membrane Dynamics Improves B‐Vitamin Uptake in Caco‐2 Cells
ChemFoodChem, Volume 2, Issue 2, June 2026.Natural bioenhancers such as extracts from ginger, turmeric, black pepper, and spearmint increase the uptake of vitamins B1, B5, B6, and B7 in Caco‐2 cells. Micellized formulations further increase efficacy. These findings indicate that altered membrane fluidity contributes to enhanced cellular absorption, providing a new route to improve vitamin B ...
Verena Preinfalk +9 more
wiley +1 more source