A functional yeast survival screen of tumor-derived cDNA libraries designed to identify anti-apoptotic mammalian oncogenes [PDF]
, 2013 Yeast cells can be killed upon expression of pro-apoptotic mammalian proteins. We have established a functional yeast survival screen that was used to isolate novel human anti-apoptotic genes overexpressed in treatment-resistant tumors.
Agaimy, Abbas +17 more
core +7 more sources
Wernicke Korsakoff syndrome in a teenage female as a complication of COVID‐19
Journal of the American College of Emergency Physicians Open, 2022 Wernicke encephalitis (WE) is usually associated with alcohol use disorder and caused by a deficiency in thiamine. Classic findings include confusion, ataxia, and ophthalmoplegia.
Hannah Skok +2 more
doaj +1 more source
Enterohemorrhagic Escherichia coli infection inhibits colonic thiamin pyrophosphate uptake via transcriptional mechanism. [PDF]
, 2019 Colonocytes possess a specific carrier-mediated uptake process for the microbiota-generated thiamin (vitamin B1) pyrophosphate (TPP) that involves the TPP transporter (TPPT; product of the SLC44A4 gene).
Anandam, Kasin Yadunandam +4 more
core +1 more source
Harnessing Photoenzymatic Systems for Intermolecular C–H Fluorination
Angewandte Chemie, EarlyView.Despite the remarkable versatility of enzymes for catalyzing complex organic transformations under mild aqueous conditions, no biocatalytic system has been reported for intermolecular C–H fluorination. A radical photoenzymatic approach is introduced that leverages a designed de novo protein scaffold with an unnatural amino acid to achieve precise ...
Yu Zhou +7 more
wiley +2 more sources
Wernicke encephalopathy and beriberi disease presenting as STEMI-equivalent
Monaldi Archives for Chest Disease, 2023 Thiamine deficiency is commonly associated with malnutrition, alcoholism and bariatric surgery. Thiamine deficiency can manifest in different ways, especially in developing countries: as peripheric neuropathy, as Wernicke encephalopathy or as beriberi ...
Miguel Martins Carvalho +4 more
doaj +1 more source
CHRISMED Journal of Health and Research, 2018 Context: A single case of thiamine deficiency seen in a population reflects a public health problem which is preventable and easily treatable. Aim: This article describes suspected thiamine deficiency among peripartum women in a rural population in Assam
Roshine Mary Koshy +3 more
doaj +1 more source
Thiamine pyrophosphokinase deficiency: report of two Chinese cases and a literature review
Frontiers in Pediatrics, 2023 Thiamine pyrophosphokinase (TPK) deficiency, is a rare autosomal recessive disorder of congenital metabolic dysfunction caused by variants in the TPK1 gene.
Dan Zhao +9 more
doaj +1 more source
Wernicke encephalopathy complicating catatonic schizophrenia
European Psychiatry, 2021 Introduction Wernicke’s encephalopathy is a potentially fatal neurological emergency caused by thiamine deficiency. Although it is often associated with chronic alcoholism, it can also occur in all situations that lead to a thiamine deficiency such as ...
C. Rihab +7 more
doaj +1 more source
The mystery of the M74 syndrome solved: Plentiful fatty sprat as prey for salmon leads to reproduction disorder [PDF]
, 2012 Press release 4.4.2012, Finnish Game and Fisheries Research InstituteThiamine (vitamin B1) deficiency results in mortalities of yolk-sac fry of salmon (M74).
Keinänen, Marja, Vuorinen, Pekka
core +1 more source
A Patient With Thiamine Deficiency Exhibiting Muscle Edema Suggested by MRI
Frontiers in Neurology, 2018 Myalgia is sometimes observed in patients with thiamine-deficiency neuropathy. However, the detailed mechanism(s) underlying muscular manifestations have been poorly elucidated.
Kenichiro Murate +9 more
doaj +1 more source