Results 51 to 60 of about 4,470 (218)

Combining aptamers for thiamphenicol and chloramphenicol for detecting both antibiotics.

open access: yesChemical Communications
A DNA aptamer named TAP-1 for thiamphenicol (TAP) was selected using the capture-systematic evolution of ligands by exponential enrichment (SELEX) technique, exhibiting a dissociation constant (Kd) of 6.4 μM as determined by isothermal titration ...
Yun Shu, Shiyuan Liu, Juewen Liu
semanticscholar   +1 more source

Naturally Occurring CodY Variants Alter Ligand Binding, DNA Target Affinity, and Virulence in Clostridioides difficile

open access: yesMolecular Microbiology, Volume 126, Issue 1, Page 98-110, July 2026.
Single amino acid substitutions in the global regulator CodY can alter nutrient sensing and virulence regulation in Clostridioides difficile. We show that the CodY(Y146N) and CodY(V58A) variants display altered ligand binding and reduced promoter binding, leading to derepression of toxin regulatory pathways and increased virulence in vivo.
Md Kamrul Hasan   +2 more
wiley   +1 more source

Synthesis and theoretical calculations of metal-antibiotic chelation with thiamphenicol: in vitro DNA and HSA binding, molecular docking, and cytotoxicity studies

open access: yesNew Journal of Chemistry, 2021
New metal complexes showed the magic of the bivalent metal which have higher bioactivity than free ligand.
Abeer A. Sharfalddin   +3 more
semanticscholar   +1 more source

Enantiomerically Enriched Aziridine‐2‐carboxylates via Copper‐Catalyzed Reductive Kinetic Resolution of 2H‐Azirines

open access: yesAngewandte Chemie, Volume 137, Issue 26, June 24, 2025.
Kinetic resolution by copper hydride catalyzed reduction of 2H‐azirines secured optically enriched N‐H aziridine‐2‐carboxylates with excellent diastereoselectivity (>20:1) and good enantioselectivity (up to 94% ee). DFT calculations and non‐covalent interaction analysis established the reaction pathway and revealed two key non‐covalent interactions ...
Yinuo Zheng   +3 more
wiley   +2 more sources

Thiamphenicol in the treatment of chancroid. A study of 1,128 cases Tianfenicol no tratamento do cancroide. Estudo de 1.128 casos

open access: yesRevista do Instituto de Medicina Tropical de São Paulo, 2000
Thiamphenicol, an aminic derivate of hydrocarbilsulfonil propandiol, was used for the treatment of 1,171 chancroid bearing patients. Each patient was medicated with 5.0 g of granulated thiamphenicol, orally, in a single dose, and was reevaluated 3, 7 and
Walter BELDA JUNIOR   +2 more
doaj   +1 more source

A role of thiamphenicol glycinate acetylcysteinate for therapy of respiratory diseases (a review)

open access: yesМедицинский совет, 2020
This article is a review of published studies on the clinical application of thiamphenicol glycinate acetylcysteinate (TGA) in the treatment of acute and chronic upper and lower respiratory tract diseases.
S. Yu. Chikina
doaj   +1 more source

Millimeter/Nano‐Structured Metal Monolithic Catalysts: A Privileged Opportunity for Sustainable Water Purification

open access: yesRare Metals, Volume 45, Issue 6, June 2026.
ABSTRACT Cross‐scale assembly of metal (sub) nanoparticles and/or single atoms into millimeter/nanostructured metal monolithic catalysts (Min‐SMCs) is highly appealing for sustainable water cleanup, due to energy‐efficient catalyst recyclability, high infrastructure compatibility, and low metal‐releasing risks.
Jia‐Cheng E. Yang   +4 more
wiley   +1 more source

A Single Amino Acid Substitution in CspA Increases Germination Sensitivity and Broadens Bile Salt Germinant Specificity in Clostridioides difficile Spores

open access: yesEnvironmental Microbiology, Volume 28, Issue 6, June 2026.
In reservoir‐associated RT033 strains, we observe a natural rewiring of spore germination that lowers the activation threshold and broadens bile‐salt specificity, enabling germination at low germinant levels and in response to typically inhibitory bile‐salts common in animal hosts.
Isabel Roseiro   +7 more
wiley   +1 more source

Effects of some antibiotics on glutathione reductase from bovine erythrocytes

open access: yesVeterinární Medicína, 2003
This paper describes effects of some antibiotics on glutathione reductase in vitro. Glutathione reductase was purified from bovine erythrocytes. Purification procedure consisted of four steps; preparation of hemolysate, ammonium sulphate precipitation, 2'
M. Erat, H. Sakiroglu, M. Ciftci
doaj   +1 more source

PREVALENCE OF KLEBSIELLA PNEUMONIAE IN BROILER CHICKS [PDF]

open access: yesKafrelsheikh Veterinary Medical Journal, 2018
The aim of this study was to investigate the role of Klebsiella pneumoniae bacterial infection in causing mortalities in broiler chicks. Trials were carried out to isolate and identify Klebsiella Pneumoniae Spp from 1-7day-old broiler chicks suffering ...
A.A. El-Gohary   +2 more
doaj   +1 more source

Home - About - Disclaimer - Privacy