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N-Acetylcysteine amide: a derivative to fulfill the promises of N-Acetylcysteine
Free Radical Research, 2013 In the present human health scenario, implication of oxidative stress in numerous pathologies including neurodegenerative, cardiovascular, liver, renal, pulmonary disorders, and cancer has gained attention. N-Acetylcysteine (NAC), a popular thiol antioxidant, has been clinically used to treat various pathophysiological disorders.
K Sunitha +2 more
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Medical and Dietary Uses of N-Acetylcysteine [PDF]
Antioxidants, 2019 N-acetylcysteine (NAC), a plant antioxidant naturally found in onion, is a precursor to glutathione. It has been used as a drug since the 1960s and is listed on the World Health Organization (WHO) Model List of Essential Medicines as an antidote in poisonings.
Špela Salamon +2 more
exaly +6 more sources
Topical Instillation of N-Acetylcysteine and N-Acetylcysteine Amide Impedes Age-Related Lens Opacity in Mice [PDF]
BiomoleculesCataracts, the leading cause of blindness globally, are caused by oxidative stress and inflammation, which disrupt lens transparency due to increased accumulation of reactive oxygen species (ROS) as well as protein and DNA damage during aging.
Hidetoshi Ishida +6 more
doaj +2 more sources
Efficiency evaluation of Amlodipine combined with N-acetylcysteine on Indomethacin-induced gastritis in rats [PDF]
Research Results in Pharmacology, 2022 Introduction: It is a well-known phenomenon that nonsteroidal anti-inflammatory drugs cause gastric mucosal damage. Amlodipine is a third generation dihydropyridine-type calcium channel blocker; it can inhibit inflammatory cytokines and enhance ...
Yara Annouf, Shaza Al laham, Eyad Chatty
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Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization
Pharmaceuticals, 2023 Parenteral N-acetylcysteine has a wide variety of clinical applications, but its use can be limited by a poor chemical stability. We managed to control parenteral N-acetylcysteine stability, and to study the influence of additives on the decrease of N ...
Nicolas Primas +9 more
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Evaluation of N-acetylcysteine for the prevention of contrast-induced nephropathy [PDF]
Journal of Community Hospital Internal Medicine Perspectives, 2015 Background: Contrast-induced nephropathy (CIN) remains a leading cause of acute renal failure in hospitalized patients. N-Acetylcysteine has been studied previously for the prevention of CIN, resulting in mixed findings.
Sara K. Richter, Andrew J. Crannage
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The Role of N-Acetylcysteine in Obsessive-Compulsive (OCD) and Related Disorders
European Psychiatry, 2022 Introduction N-acetylcysteine is known for its uses in non-psychiatric conditions, such as paracetamol overdose and as a mucolytic. The rationale for its administration in psychiatric conditions is based on its ability reducing synaptic glutamate ...
J. Sá Couto +4 more
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Non-Intentional N-Acetylcysteine Overdose Associated with Cerebral Edema and Brain Death
Case Reports in Gastroenterology, 2023 N-acetylcysteine is the established treatment for acetaminophen toxicity. This medication’s complex dosing schedule engenders a high incidence of medication errors.
Emma E.M. Spence +4 more
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Better together? Treating traumatic brain injury with minocycline plus N-acetylcysteine
Neural Regeneration Research, 2022 Traumatic brain injury has a complex pathophysiology that produces both rapid and delayed brain damage. Rapid damage initiates immediately after injury. Treatment of traumatic brain injury is typically delayed many hours, thus only delayed damage can be ...
Siobhán Lawless, Peter J Bergold
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Asian Pacific Journal of Reproduction, 2020 Objective: To study the influence of N-acetylcysteine on the pituitary-gonadal axis hormones and protamine expression level in streptozotocin-induced diabetic male rats. Methods: Forty-two adult male Wistar rats were divided into 6 groups, with 7 rats in
Maryam Hassanzadeh Moghadam +3 more
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