N-acetylcysteine Pharmacology and Applications in Rare Diseases—Repurposing an Old Antioxidant
Antioxidants, 2023 N-acetylcysteine (NAC), a precursor of cysteine and, thereby, glutathione (GSH), acts as an antioxidant through a variety of mechanisms, including oxidant scavenging, GSH replenishment, antioxidant signaling, etc. Owing to the variety of proposed targets,
Siddhee A. Sahasrabudhe +2 more
semanticscholar +1 more source
Stability Study of Parenteral N-Acetylcysteine, and Chemical Inhibition of Its Dimerization
Pharmaceuticals, 2023 Parenteral N-acetylcysteine has a wide variety of clinical applications, but its use can be limited by a poor chemical stability. We managed to control parenteral N-acetylcysteine stability, and to study the influence of additives on the decrease of N ...
Nicolas Primas +9 more
doaj +1 more source
Evaluation of N-acetylcysteine for the prevention of contrast-induced nephropathy [PDF]
Journal of Community Hospital Internal Medicine Perspectives, 2015 Background: Contrast-induced nephropathy (CIN) remains a leading cause of acute renal failure in hospitalized patients. N-Acetylcysteine has been studied previously for the prevention of CIN, resulting in mixed findings.
Sara K. Richter, Andrew J. Crannage
doaj +1 more source
Advances in the Use of N-Acetylcysteine in Chronic Respiratory Diseases
Antioxidants, 2023 N-acetylcysteine (NAC) is widely used because of its mucolytic effects, taking part in the therapeutic protocols of cystic fibrosis. NAC is also administered as an antidote in acetaminophen (paracetamol) overdosing.
D. Mokra +3 more
semanticscholar +1 more source
N-Acetylcysteine for Preventing Acetaminophen-Induced Liver Injury: A Comprehensive Review
Frontiers in Pharmacology, 2022 Aims: N-Acetylcysteine (NAC) is used as an antidote in acetaminophen (APAP) overdose to prevent and mitigate drug-induced liver injury (DILI). Our objective was to systematically review evidence of the use of NAC as a therapeutic option for APAP overdose
A. Licata +6 more
semanticscholar +1 more source
Comparing N-Acetylcysteine and 4-Methylpyrazole as Antidotes for Acetaminophen Overdose
Archives of Toxicology, 2022 Acetaminophen (APAP) overdose can cause hepatotoxicity and even liver failure. N-acetylcysteine (NAC) is still the only FDA-approved antidote against APAP overdose 40 years after its introduction. The standard oral or intravenous dosing regimen of NAC is
J. Akakpo +4 more
semanticscholar +1 more source
N-Acetylcysteine: A Review of Clinical Usefulness (an Old Drug with New Tricks)
Journal of Nutrition and Metabolism, 2021 Objective To review the clinical usefulness of N-acetylcysteine (NAC) as treatment or adjunctive therapy in a number of medical conditions. Use in Tylenol overdose, cystic fibrosis, and chronic obstructive lung disease has been well documented, but there
Gerry K Schwalfenberg
semanticscholar +1 more source
The Role of N-Acetylcysteine in Obsessive-Compulsive (OCD) and Related Disorders
European Psychiatry, 2022 Introduction N-acetylcysteine is known for its uses in non-psychiatric conditions, such as paracetamol overdose and as a mucolytic. The rationale for its administration in psychiatric conditions is based on its ability reducing synaptic glutamate ...
J. Sá Couto +4 more
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Non-Intentional N-Acetylcysteine Overdose Associated with Cerebral Edema and Brain Death
Case Reports in Gastroenterology, 2023 N-acetylcysteine is the established treatment for acetaminophen toxicity. This medication’s complex dosing schedule engenders a high incidence of medication errors.
Emma E.M. Spence +4 more
doaj +1 more source
Better together? Treating traumatic brain injury with minocycline plus N-acetylcysteine
Neural Regeneration Research, 2022 Traumatic brain injury has a complex pathophysiology that produces both rapid and delayed brain damage. Rapid damage initiates immediately after injury. Treatment of traumatic brain injury is typically delayed many hours, thus only delayed damage can be ...
Siobhán Lawless, Peter J Bergold
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