Medical and Dietary Uses of N-Acetylcysteine [PDF]
Antioxidants, 2019 N-acetylcysteine (NAC), a plant antioxidant naturally found in onion, is a precursor to glutathione. It has been used as a drug since the 1960s and is listed on the World Health Organization (WHO) Model List of Essential Medicines as an antidote in ...
Špela Salamon +2 more
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N-Acetylcysteine (NAC): Impacts on Human Health
Antioxidants, 2021 N-acetylcysteine (NAC) is a medicine widely used to treat paracetamol overdose and as a mucolytic compound. It has a well-established safety profile, and its toxicity is uncommon and dependent on the route of administration and high dosages.
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N-Acetylcysteine as an antioxidant and disulphide breaking agent: the reasons why
Free Radical Research, 2018 The main molecular mechanisms explaining the well-established antioxidant and reducing activity of N-acetylcysteine (NAC), the N-acetyl derivative of the natural amino acid l-cysteine, are summarised and critically reviewed. The antioxidant effect is due
Giancarlo Aldini +2 more
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N-Acetylcysteine amide: a derivative to fulfill the promises of N-Acetylcysteine
Free Radical Research, 2013 In the present human health scenario, implication of oxidative stress in numerous pathologies including neurodegenerative, cardiovascular, liver, renal, pulmonary disorders, and cancer has gained attention. N-Acetylcysteine (NAC), a popular thiol antioxidant, has been clinically used to treat various pathophysiological disorders.
Mahadevappa Hemshekhar +2 more
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Effect of N-acetylcysteine on exacerbations of bronchiectasis (BENE): a randomized controlled trial
Respiratory Research, 2019 Background N-acetylcysteine is a classic mucolytic agent. This study aimed to investigate the efficacy of N-acetylcysteine on reducing the risk of exacerbations in bronchiectasis patients. Methods A prospective, randomized, controlled trial was conducted
Qian Qi +8 more
doaj +2 more sources
Overview on the Effects of N-Acetylcysteine in Neurodegenerative Diseases
Molecules, 2018 N-acetylcysteine (NAC), which is an acetylated cysteine compound, has aroused scientific interest for decades due to its important medical applications. It also represents a nutritional supplement in the human diet.
Emanuela Mazzon +2 more
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Efficacy and safety of N-acetylcysteine in patients with mild cognitive impairment undergoing exercise-based cardiac rehabilitation program: a randomized controlled trial [PDF]
Alzheimer’s Research & TherapyBackground Oxidative stress is implicated in the etiology of mild cognitive impairment. We hypothesized that oral supplementation with N-acetylcysteine, a precursor to the antioxidant glutathione, would improve cognitive outcomes among individuals with ...
Damien Gallagher +17 more
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Topical Instillation of N-Acetylcysteine and N-Acetylcysteine Amide Impedes Age-Related Lens Opacity in Mice [PDF]
BiomoleculesCataracts, the leading cause of blindness globally, are caused by oxidative stress and inflammation, which disrupt lens transparency due to increased accumulation of reactive oxygen species (ROS) as well as protein and DNA damage during aging.
Hidetoshi Ishida +6 more
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Efficiency evaluation of Amlodipine combined with N-acetylcysteine on Indomethacin-induced gastritis in rats [PDF]
Research Results in Pharmacology, 2022 Introduction: It is a well-known phenomenon that nonsteroidal anti-inflammatory drugs cause gastric mucosal damage. Amlodipine is a third generation dihydropyridine-type calcium channel blocker; it can inhibit inflammatory cytokines and enhance ...
Yara Annouf, Shaza Al laham, Eyad Chatty
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Pharmacology and Therapeutics, 2021 Initially adopted as a mucolytic about 60 years ago, the cysteine prodrug N-acetylcysteine (NAC) is the standard of care to treat paracetamol intoxication, and is included on the World Health Organization's list of essential medicines.
B. Pedre +3 more
semanticscholar +1 more source