Results 11 to 20 of about 4,651 (214)

On the functionalization of benzo[e][2,1]thiazine [PDF]

Beilstein Journal of Organic Chemistry, 2009
The reactions of benzo[e][2,1]thiazine-4-chloro-3-carbaldehydes 1 and benzo[e][2,1]thiazine-4-chloro-3-carbonitriles 2 with a number of oxidizing and reducing agents are reported.
Kirill Popov, Tatyana Volovnenko, Julian Volovenko   +2 more
doaj   +4 more sources

Synthesis, Characterization and Biological Activities of 3,5-Diaryltetrahydro-N-[(phenylamino)methyl]-1,4-thiazine-1,1-dioxide [PDF]

E-Journal of Chemistry, 2009
Synthesis of 3,5-diaryltetrahydro-N- [(4’-nitroanilino)methyl-thiazine-1,1-dioxide and N-[(4’-methylanilino)methyl-]-1,4-thiazine-1,1-dioxides by condensing 3,5-diaryl-tetrahydro-1,4-thiazine-1,1-dioxide with formaldehyde and 4-nitroaniline/4 ...
V. Sundari, G. Nagarajan, S. Gurumurthy, R. Valliappan   +3 more
doaj   +2 more sources

An Ugi-Joullié Platform for Medicinally Relevant 1,4-Dihydrobenzothiazines. [PDF]

ChemMedChem
A series of benzothiazine derivatives was efficiently synthesized via an UJ‐2CR of a preformed imine and diverse isocyanides. The method features mild, room‐temperature conditions, broad functional‐group tolerance, and scalability, enabling rapid access to a chemically diverse library of 19 adducts with potential for further medicinal chemistry ...
Lei X, Tomza C, Giannakaki MA, Gkountouva M, Olbasalis I, Giappa RM, Stoumpos CC, Kontogiorgis C, Dömling A, Neochoritis CG.   +9 more
europepmc   +2 more sources

Organocatalyzed Enantio- and Diastereoselective Domino [3+2]-Dipolar Cycloaddition: Synthesis of Chiral Pyrrorlo-thiazine-2-carbaldehydes and Dihydropyrrole-3-carbaldehydes [PDF]

, 2023
1,3-Dipolar cycloaddition of azomethine ylide and dipolarophile is an efficient method to construct N, S heterocycles such as thiazoles, 1,4-thiazines, and their chiral polyhydro derivatives.
Venkata Surya Kumar , Choutipalli, Venkatesan , Subramanian, Govindasamy , Sekar, Solai, Pandidurai   +3 more
core   +2 more sources

Gold-Catalyzed 1,3-Thiazine Formation and Uncommon Tautomer Isolation [PDF]

, 2022
[Image: see text] This work represents the first example of a gold-catalyzed formation of 1,3-thiazine/1,3-thiazinane by means of a catalytic approach and further uncommon isolation of the two tautomers. The developed protocol gives rise to a broad scope
Gimeno, M. Concepción, Raquel P. Herrera, Herrera, R. P., Canudo-Barreras, G., Daniel Salvador, Canudo-Barreras, Guillermo, Gimeno, M. C., M. Concepción Gimeno, Salvador, D., Guillermo Canudo-Barreras, Herrera, Raquel P., Salvador, Daniel, Salvador-Gil, Daniel   +12 more
core   +1 more source

Is it possible to differentiate between 2-phenylaminodihydro-1,3-thiazine from 2-phenyliminotetrahydro-1,3-thiazine by spectral methods? New glance to the old problem [PDF]

, 2021
Several studies have reported the presence of amine and imine tautomeric forms for hydrogenated 1,3-thiazine derivatives. However, identification of their tautomeric forms by UV, FTIR and mass-spectral methods does not yield expected results.
Adizov, Shahobiddin, Reymov, Akhmed, Eshimbetov, Alisher, Kaur, Inderpreet, Inderpreet Kaur, Akhmed Reymov, Alisher Eshimbetov, Shahobiddin Adizov   +7 more
core   +1 more source

DESIGN, FACILE SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL 1,3-THIAZINE DERIVATIVES AS POTENTIAL ANTICONVULSANT AGENTS [PDF]

, 2016
Objective: Chalcones and their heterocyclic analogs represent an important class of small molecules having anticonvulsant activities. Therefore, inthis study, the synthesis and anticonvulsant activity of some new chalcones and 1,3-thiazines were ...
Basha Shaik, Afzal, Murthy M, Srinivasa, B, Ravindar   +2 more
core   +3 more sources

The anti-HIV, anti-tumor activity of allyl derivatives of 1,2,4-triazole-5-thione, 1,3,4-thiadiazol-2-ylamine and derivatives of bicyclic systems: 1,2,4-triazole[3,4-b]1,3-thiazine, 1,2,4-triazole[3,2-b]1,3-thiazine, thiazolo[2,3-c][1,2,4]triazole

Current Issues in Pharmacy and Medical Sciences, 2012
The isomerization of 5H-3,7-diphenyl 6,7-dihydro-1,2,4-triazole[3,4-b] 1,3-thiazine (1) in a sealed tube, in the presence of aqueous Hbr, was carried out, and 7H-2,5-diphenyl-5,6-dihydro 1,2,4-triazole[3,2-b]1,3-thiazine (2) was obtained.
Leokadia Strzemecka
doaj   +1 more source

Isomorphous diethyl 1-(4-chlorobenzyl)-4-(4-chlorophenyl)-2,2-dioxo-3,4,6,7,8,8a-hexahydro-1H-pyrrolo[2,1-c][1,4]thiazine-1,3-dicarboxylate and its 1-(4-methylbenzyl)-4-(4-methylphenyl)-substituted analogue obeying the chloro–methyl exchange rule

Acta Crystallographica Section E: Crystallographic Communications, 2018
Accurate studies on the effect of substituents on the crystal packing are essential for understanding the intermolecular interactions and thus paving the way to crystal structure prediction.
R. Sribala, N. Srinivasan, S. Indumathi, R. V. Krishnakumar   +3 more
doaj   +1 more source

Crystal structure of Brinzolamide: a carbonic anhydrase inhibitor

Acta Crystallographica Section E: Crystallographic Communications, 2016
In crystal structure of the title compound, C12H21N3O5S3 [systematic name: (R)-4-ethylamino-2-(3-methoxypropyl)-3,4-dihydro-2H-thieno[3,2-e][1,2]thiazine-6-sulfonamide 1,1-dioxide], there exist three kinds of hydrogen-bonding interactions.
Huirong Zheng, Benyong Lou
doaj   +1 more source