The Multifaceted Opportunities Provided by the Pheomelanin-Inspired 1,4-Benzothiazine Chromophore: A Still-Undervalued Issue [PDF]
Molecules, 2023 1,4-Benzothiazines are the main building blocks of the naturally occurring pheomelanin pigments, and their chromophoric properties have been strongly related to the well-known phototoxicity of these pigments, partly responsible for the high incidence of ...
Maria Laura Alfieri, Lucia Panzella
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N-Arylacetamide derivatives of methyl 1,2-benzothiazine-3-carboxylate as potential drug candidates for urease inhibition [PDF]
Royal Society Open Science, 2023 Urease enzyme is an infectious factor that provokes the growth and colonization of virulence pathogenic bacteria in humans. To overcome the deleterious effects of bacterial infections, inhibition of urease enzyme is one of the promising approaches.
Sajila Hina +7 more
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Rational Design, Synthesis, Molecular Docking, and Biological Evaluations of New Phenylpiperazine Derivatives of 1,2-Benzothiazine as Potential Anticancer Agents [PDF]
MoleculesThe aim of this study was to obtain new, safe, and effective compounds with anticancer activity since cancer is still the leading cause of mortality worldwide.
Berenika M. Szczęśniak-Sięga +4 more
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Potential anti-amoebic effects of synthetic 1,4-benzothiazine derivatives against Acanthamoeba castellanii. [PDF]
Heliyon, 2023 A rare but lethal central nervous system disease known as granulomatous amoebic encephalitis (GAE) and potentially blinding Acanthamoeba keratitis are diseases caused by free-living Acanthamoeba.
Alishba +7 more
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The Benzothiazine Core as a Novel Motif for DNA-Binding Small Molecules [PDF]
Molecules, 2023 A new series of 4H-1,3-benzothiazine dyes were prepared and fully characterized in an aqueous medium. Benzothiazine salts were synthesized either through the classical synthetic pathway using Buchwald–Hartwig amination or through economical and ...
Milena Mlakić +10 more
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Advanced Synthesis and Catalysis, 2021 Three-dimensional aza-analogues of 1,2benzothiazine 1,1-dioxides have been prepared from sulfonimidamides. Two different protocols are presented. The first is a rhodium-catalyzed annulation reaction with α-sulfonyloxyketones leading to 4unsubstituted ...
Jan-Hendrik Schöbel +2 more
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Anti-Inflammatory Activity of 1,2-Benzothiazine 1,1-Dioxide Derivatives [PDF]
PharmaceuticalsThere is an urgent need to develop new anti-inflammatory compounds due to the versatility of their applications and the side effects associated with currently used nonsteroidal anti-inflammatory drugs (NSAIDs).
Berenika M. Szczęśniak-Sięga +1 more
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Synthesis of dimeric 1,2-benzothiazine 1,1-dioxide scaffolds: molecular structures, Hirshfeld surface analysis, DFT and enzyme inhibition studies. [PDF]
RSC Adv1,2-Benzothiazines are bioactive compounds with diverse pharmacological properties. We report here the synthesis of a series of dimers containing 1,2-benzothiazine scaffolds as potential pharmacophores.
Fatima M +9 more
europepmc +2 more sources
Derivatives of benzo-1,4-thiazine-3-carboxylic acid and the corresponding amino acid conjugates [PDF]
Beilstein Journal of Organic Chemistry, 2022 Herein, we present the synthesis and utilization of derivatives of 4H-benzo[b][1,4]thiazine-3-carboxylic acid. These benzothiazine compounds were assembled via the coupling of aminothiols and bromopyruvates.
Péter Kisszékelyi +4 more
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Scientia Pharmaceutica, 2018 In order to determine the regularities of the structure–analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and some of its ...
Igor V Ukrainets +2 more
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