Results 1 to 10 of about 286 (167)
New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylates [PDF]
Scientia Pharmaceutica, 2017 According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates has been obtained as potential analgesics.
Liliana Azotla-Cruz +5 more
doaj +5 more sources
4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic Acid. Peculiarities of Preparation, Structure, and Biological Properties [PDF]
Scientia Pharmaceutica, 2018 In order to determine the regularities of the structure–analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and some of its ...
Igor V Ukrainets +2 more
exaly +4 more sources
2,1-Benzothiazine - (quinolin/thiophen)yl hydrazone frameworks as new monoamine oxidase inhibitory agents; synthesis, in vitro and in silico investigation. [PDF]
RSC Adv, 2023 Two series of new 2,1-benzothiazine-heteroaryl ethylidene derivatives 7(a–f) and 9(a–k) have been synthesized in excellent yields and tested against MAOs.
Javid N +6 more
europepmc +5 more sources
Nucleophile-induced ring contraction in pyrrolo[2,1-c][1,4]benzothiazines: access to pyrrolo[2,1-b][1,3]benzothiazoles [PDF]
Beilstein Journal of Organic Chemistry, 2023 Pyrrolo[2,1-b][1,3]benzothiazoles are an important class of fused sulfur and nitrogen-containing heterocycles intensively studied in medicinal chemistry and pharmacology.
Ekaterina A. Lystsova +3 more
doaj +2 more sources
Preparation of S-2-halophenyl-2,1-benzothiazines. [PDF]
Tetrahedron, 2021 Derivatives of 2,1-benzothiazines are useful synthetic intermediates for a variety of applications. We became interested in developing a one-pot procedure to S-2-halophenyl-2,1-benzothiazines as potential precursors to P,N type ligands for metals. Accordingly, we reacted S-2-halophenyl-S-methylsulfoximines with 2-bromobenzaldehydes using the Buchwald ...
Garimalla A, Harmata M.
europepmc +3 more sources
Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms [PDF]
Scientia Pharmaceutica, 2018 Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in ...
Igor V. Ukrainets +7 more
doaj +2 more sources
ARKIVOC, 2003 Radical cyclization and ionic cyclization onto the aromatic rings of 2-arylethanesulfonamides with polymer-supported hypervalent iodine reagents were examined, where the reactivities appear to be dependent on the substituent bonded to the nitrogen atom of 2arylethanesulfonamides to obtain the corresponding 3,4-dihydro-2,1-benzothiazine 2,2-dioxides.
Kenji Sakuratani, Hideo Togo
doaj +3 more sources
Molbank, 2023 The reaction of 3-benzoylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-trione with 2,3-dimethylquinoxaline afforded 3-benzoyl-2-hydroxy-3a-[(3-methylquinoxalin-2-yl)methyl]-1H-pyrrolo[2,1-c][1,4]benzothiazine-1,4(3aH)-dione in a moderate yield. The compound was
Ekaterina A. Lystsova +1 more
doaj +1 more source
Molecules, 2023 Acyl(imidoyl)ketenes are highly reactive heterocumulenes that enable diversity-oriented synthesis of various drug-like heterocycles. Such ketenes, bearing heterocyclic substituents, afford angularly fused pyridin-2(1H)-ones in their [4+2 ...
Ekaterina A. Lystsova +4 more
doaj +1 more source
Natural Product Communications, 2022 Research on multitargeting drugs is emerging, focusing on the discovery of agents that simultaneously act on more than one biological target. Here, a novel synthetic route to access the fused-heterocycles 1,4-dihydropyrazolo[4,3- b ]indoles ( 4 ) from ...
Vo Ngoc Binh +3 more
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