4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylic Acid. Peculiarities of Preparation, Structure, and Biological Properties [PDF]
Scientia Pharmaceutica, 2018 In order to determine the regularities of the structure–analgesic activity relationship, the peculiarities of obtaining, the spatial structure, and biological properties of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid and some of its ...
Natali I Voloshchuk +2 more
exaly +4 more sources
New Synthesis, Structure and Analgesic Properties of Methyl 1-R-4-Methyl-2,2-Dioxo-1H-2λ6,1-Benzothiazine-3-Carboxylates [PDF]
Scientia Pharmaceutica, 2017 According to the principles of the methodology of bioisosteric replacements a series of methyl 1-R-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylates has been obtained as potential analgesics.
Igor V Ukrainets +2 more
exaly +4 more sources
Nucleophile-induced ring contraction in pyrrolo[2,1-c][1,4]benzothiazines: access to pyrrolo[2,1-b][1,3]benzothiazoles [PDF]
Beilstein Journal of Organic Chemistry, 2023 Pyrrolo[2,1-b][1,3]benzothiazoles are an important class of fused sulfur and nitrogen-containing heterocycles intensively studied in medicinal chemistry and pharmacology.
Ekaterina A. Lystsova +3 more
doaj +2 more sources
Preparation of S-2-halophenyl-2,1-benzothiazines. [PDF]
Tetrahedron, 2021 Derivatives of 2,1-benzothiazines are useful synthetic intermediates for a variety of applications. We became interested in developing a one-pot procedure to S-2-halophenyl-2,1-benzothiazines as potential precursors to P,N type ligands for metals. Accordingly, we reacted S-2-halophenyl-S-methylsulfoximines with 2-bromobenzaldehydes using the Buchwald ...
Garimalla A, Harmata M.
europepmc +3 more sources
5H-Benzo[d]Benzo[4,5]Imidazo[2,1-b][1,3]Thiazine as a Novel Electron-Acceptor Cored High Triplet Energy Bipolar Host Material for Efficient Solution-Processable Thermally Activated Delayed Fluorescence Organic Light-Emitting Diodes [PDF]
Frontiers in Chemistry, 2020 Organic entities that can transport electrons are seldom available to develop adequate bipolar host materials applicable for solution-processable thermally activated delayed fluorescence (TADF)-organic light-emitting diodes (OLEDs).
Mallesham Godumala +9 more
doaj +2 more sources
2,1-Benzothiazine - (quinolin/thiophen)yl hydrazone frameworks as new monoamine oxidase inhibitory agents; synthesis, in vitro and in silico investigation. [PDF]
RSC Adv, 2023 Two series of new 2,1-benzothiazine-heteroaryl ethylidene derivatives 7(a–f) and 9(a–k) have been synthesized in excellent yields and tested against MAOs.
Javid N +6 more
europepmc +3 more sources
NorA Efflux Pump Inhibitors: Expanding SAR Knowledge of Pyrazolo[4,3-c][1,2]benzothiazine 5,5-Dioxide Derivatives. [PDF]
Arch Pharm (Weinheim)The pyrazolo[4,3‐c][1,2]benzothiazine 5,5‐dioxide class was investigated with the aim of enlarging the array of Staphylococcus aureus NorA efflux pump inhibitors. The ethidium bromide efflux assay was used as a first indication of NorA inhibition; then, the ability of compounds to synergize with ciprofloxacin (CPX) against both wild‐type and resistant ...
Cernicchi G +14 more
europepmc +2 more sources
Synthesis, Crystal Structure, and Biological Activity of Ethyl 4-Methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate Polymorphic Forms [PDF]
Scientia Pharmaceutica, 2018 Continuing the search for new potential analgesics among the derivatives of 4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylic acid, the possibility of obtaining its esters by the alkylation of the corresponding sodium salt with iodoethane in ...
Igor V. Ukrainets +7 more
doaj +2 more sources
ARKIVOC, 2003 Radical cyclization and ionic cyclization onto the aromatic rings of 2-arylethanesulfonamides with polymer-supported hypervalent iodine reagents were examined, where the reactivities appear to be dependent on the substituent bonded to the nitrogen atom of 2arylethanesulfonamides to obtain the corresponding 3,4-dihydro-2,1-benzothiazine 2,2-dioxides.
Kenji Sakuratani, Hideo Togo
doaj +3 more sources
Pakistan Journal of Pharmaceutical Sciences, 2021 Diabetes mellitus (DM) is a metabolic disorder characterized by frequent urination, hunger and high blood sugar level. α-glucosidase inhibitors are considered as a frontline treatment for the DM.
Shakeel Ahmad +6 more
doaj +2 more sources