Results 21 to 30 of about 286 (167)

1,2-Бензоксатіїн-4(3Н)-он 2,2-діоксид – малодосліджений білдинг-блок із високим синтетичним та фармакологічним потенціалом: синтез, хімічні властивості, біологічна активність [PDF]

, 2021
Aim. To analyze the available literature data on the methods of synthesis, chemical transformations and the biological activity of derivatives containing a sultone core – 1,2-benzoxathiin-4(3H)-one 2,2-dioxide – and to show the possibilities of their ...
Hryhoriv, Halyna V., Lega, Dmitry A., Shemchuk, Leonid A.   +2 more
core   +2 more sources

SYNTHESIS OF NOVEL ANTI-BACTERIAL 2,1-BENZOTHIAZINE 2,2-DIOXIDES DERIVED FROM METHYL ANTHRANILATE [PDF]

Journal of the Chilean Chemical Society, 2011
A convenient ultrasound assisted synthesis of new anti-bacterial N-benzylidene-N’-(1-methyl-2, 2-dioxo-2,3-dihydro-1H-2λ6-benzo[c][1,2]thiazin-4-ylidene)hydrazines from methyl anthranilate is reported. Methyl anthranilate was reacted with methane sulfonyl chloride, followed by N-alkylation and subsequent base catalyzed cyclization.
SHAFIQ, MUHAMMAD, ZIA-UR-REHMAN, MUHAMMAD, ULLAH KHAN, ISLAM, NADEEM ARSHAD, MUHAMMAD, AHMED KHAN, SIRAJ   +4 more
openaire   +2 more sources

Access to [2,1]Benzothiazine S,S-Dioxides from β-Substituted o-Nitrostyrenes and Sulfur [PDF]

The Journal of Organic Chemistry, 2020
[2,1]Benzothiazine S,S-dioxides 2 were synthesized by simply heating o-nitrostyrenes with elemental sulfur in 3-picoline with complete atom economy. This reaction was found to occur without any added catalyst and consist of a cascade of reduction of the nitro group, sulfuration of a C-H of the double bond, oxidation of a sulfur atom to its highest ...
Thi Mo Nguyen, Hoang Anh Cao, Thi Thuong Thuong Cao, Satoki Koyama, Dinh Hung Mac, Thanh Binh Nguyen   +5 more
openaire   +2 more sources

The Crystal Structure of N-(1-Arylethyl)-4-methyl- 2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides as the Factor Determining Biological Activity Thereof

Scientia Pharmaceutica, 2019
In order to detect new structural and biological patterns in a series of hetaryl-3-carboxylic acid derivatives, the optically pure (S)- and (R)-enantiomers of N-(1-arylethyl)-4-methyl- 2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides, their true ...
Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Irina A. Danylova, Galina Sim   +7 more
doaj   +1 more source

N-Benzoyl-N-methylsulfonyl anthranilates: unexpected cyclization reaction to 4-alkoxy-2,1-benzothiazines [PDF]

Arkivoc, 2011
The synthesis of 4-alkoxy-1H-2,1-benzothiazine 2,2-dioxide derivatives was achieved through an unexpected base-mediated cyclization of N-benzoyl-N-methylsulfonylanthranilates. A reaction mechanism involving the sulfene species has been postulated.
MANFRONI, GIUSEPPE, MESCHINI, FRANCESCO, COSTANTINO, FERDINANDO, TABARRINI, Oriana, CECCHETTI, Violetta   +4 more
openaire   +1 more source

(3S,4Z)-3-Chloro-1-methyl-4-[(2E)-(3-methylbenzylidene)hydrazinylidene]-3,4-dihydro-1H-2,1-benzothiazine 2,2-dioxide

Acta Crystallographica Section E, 2012
In the title compound, C17H16ClN3O2S, the dihedral angle between the benzene rings is 7.75 (13)°. The thiazine ring adopts an envelope conformation with the S atom as the flap at a distance of 0.813 (2) &#197 ...
Muhammad Shafiq, M. Nawaz Tahir, Islam Ullah Khan, Muhammad Zia-Ur-Rehman   +3 more
doaj   +1 more source

Nitrogen-centered radicals in functionalization of sp2 systems : generation, reactivity, and applications in synthesis [PDF]

, 2022
The chemistry of nitrogen-centered radicals (NCRs) has plentiful applications in organic synthesis, and they continue to expand as our understanding of these reactive species increases.
Fenner, Sabine, Murphy, John A., Pratley, Cassie   +2 more
core   +1 more source

Benzo[1,5]thiazepine: Synthesis, Reactions, Spectroscopy, and Applications

Organic Chemistry International, Volume 2013, Issue 1, 2013., 2013
This review article deals with synthesis and reactions of benzo[1,5]thiazepines and the related derivatives and their applications, biological activity as well as spectroscopic data. Most of the reported data on the methods of synthesis, chemical reactions, and biological activity of these heterocycles published over the last ten years are reviewed in ...
Khairy A. M. El-Bayouki, William Setzer
wiley   +1 more source

Спіро[бензо[е]пірано[3,2-с][1,2]оксатіїн-4,3’-індол]-3-карбонітрил 5,5-діоксиди: синтез і вивчення біологічної активності [PDF]

, 2019
The development of medicines with several pharmacological activities, including the analgesic, anti-inflammatory and antimicrobial properties, is one of the challenging tasks of modern medicinal chemistry.Aim. To expand the range of novel spiro-condensed
Grygoriv, G. V., Lega, D. A., Shebeko, S. K., Shemchuk, L. A., Starchikova, I. L., Zimin, S. M., Zupanets, I. A.   +6 more
core   +2 more sources

Molecular Conformations and Biological Activity of N-Hetaryl(aryl)alkyl-4-methyl-2,2-dioxo-1H-2λ⁶,1-benzothiazine-3-carboxamides

Scientia Pharmaceutica, 2018
The analysis of our previous studies on the search for synthetic analgesics among N-R-amides of bicyclic hetaryl-3-carboxylic acids has been performed; on its basis N-hetaryl(aryl)-alkyl-4-methyl-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxamides have ...
Igor V. Ukrainets, Ganna M. Hamza, Anna A. Burian, Natali I. Voloshchuk, Oxana V. Malchenko, Svitlana V. Shishkina, Lina A. Grinevich, Vasyl V. Grynenko, Galina Sim   +8 more
doaj   +1 more source