Results 11 to 20 of about 190 (131)

3-Benzoyl-2-hydroxy-3a-[(3-methylquinoxalin-2-yl)methyl]-1H-pyrrolo[2,1-c][1,4]benzothiazine-1,4(3aH)-dione

Molbank, 2023
The reaction of 3-benzoylpyrrolo[2,1-c][1,4]benzothiazine-1,2,4-trione with 2,3-dimethylquinoxaline afforded 3-benzoyl-2-hydroxy-3a-[(3-methylquinoxalin-2-yl)methyl]-1H-pyrrolo[2,1-c][1,4]benzothiazine-1,4(3aH)-dione in a moderate yield. The compound was
Ekaterina A. Lystsova, Ekaterina E. Khramtsova   +1 more
doaj   +1 more source

Approach to Pyrido[2,1-b][1,3]benzothiazol-1-ones via In Situ Generation of Acyl(1,3-benzothiazol-2-yl)ketenes by Thermolysis of Pyrrolo[2,1-c][1,4]benzothiazine-1,2,4-triones

Molecules, 2023
Acyl(imidoyl)ketenes are highly reactive heterocumulenes that enable diversity-oriented synthesis of various drug-like heterocycles. Such ketenes, bearing heterocyclic substituents, afford angularly fused pyridin-2(1H)-ones in their [4+2 ...
Ekaterina A. Lystsova, Alexander S. Novikov, Maksim V. Dmitriev, Andrey N. Maslivets, Ekaterina E. Khramtsova   +4 more
doaj   +1 more source

Sulfoximine‐Directed Arene ortho‐Lithiation

European Journal of Organic Chemistry, Volume 2021, Issue 46, Page 6229-6246, December 14, 2021., 2021
The growing importance of sulfoximines in medicinal chemistry has led to a renewed interest in their synthesis and functionalization. This review describes the directed ortho‐lithiation of S‐aryl sulfoximines. Discussed are the synthesis and reactivity of five different types of o‐lithiosulfoximines, including o‐lithiosulfoximines with and without α ...
Hans‐Joachim Gais
wiley   +1 more source

Cyclization Reactions Involving 2‐Aminoarenetellurols and Derivatives of α,β‐Unsaturated Carboxylic Acids

Heteroatom Chemistry, Volume 2021, Issue 1, 2021., 2021
The reductive cyclization of arenetellurols carrying α,β‐unsaturated amide functionalities in the ortho position was investigated. Conceptually, such compounds can form 1,3‐tellurazoles without the involvement of the unsaturation in the ring closure, they can form 1,4‐tellurazinone derivatives, or they can undergo ring closure to 1,5‐tellurazepinones ...
Jayna A. Patel, Aundrea M. Lee, Donna V. Franklin, Frank R. Fronczek, Thomas Junk, Tieqiao Chen   +5 more
wiley   +1 more source

3,3′-(Phenylmethylene)bis(1-ethyl-3,4-dihydro-1H-2,1-benzothiazine-2,2,4-trione): single-crystal X-ray diffraction study, quantum-chemical calculations and Hirshfeld surface analysis

Acta Crystallographica Section E: Crystallographic Communications, 2023
The title compound, C27H26N2O6S2, possesses potential antimicrobial, analgesic, and anti-inflammatory activity. This compound has three tautomeric forms, which relative energies were estimated with quantum-chemical calculations.
Mariia O. Shyshkina, Dmitry A. Lega, Liudmyla M. Shemchuk, Irina L. Starchikova, Leonid A. Shemchuk   +4 more
doaj   +1 more source

New 1,4-Dihydropyrazolo[4,3-]indoles Induce Antiproliferation of Acute Myeloid Leukemia Cells and Inhibition of Selective Inflammatory Cytokines

Natural Product Communications, 2022
Research on multitargeting drugs is emerging, focusing on the discovery of agents that simultaneously act on more than one biological target. Here, a novel synthetic route to access the fused-heterocycles 1,4-dihydropyrazolo[4,3- b ]indoles ( 4 ) from ...
Vo Ngoc Binh, Sabrina Adorisio, Domenico V. Delfino, Quoc Anh Ngo   +3 more
doaj   +1 more source

Methyl 4-Hydroxy-2,2-Dioxo-1H-2λ⁶,1-Benzothiazine-3-Carboxylate and Its Analogs Modified in the Benzene Moiety of the Molecule as New Analgesics

Scientia Pharmaceutica, 2020
In order to identify new regularities of the “structure−analgesic activity” relationship in the series of 2,1-benzothiazine derivatives, the synthesis of methyl 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate and a group ...
Igor V. Ukrainets, Lidiya A. Petrushova, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Tatiana V. Alekseeva, Inna I. Torianyk, Alexandra A. Davidenko   +6 more
doaj   +1 more source

Access to [2,1]Benzothiazine S,S-Dioxides from β-Substituted o-Nitrostyrenes and Sulfur [PDF]

The Journal of Organic Chemistry, 2020
[2,1]Benzothiazine S,S-dioxides 2 were synthesized by simply heating o-nitrostyrenes with elemental sulfur in 3-picoline with complete atom economy. This reaction was found to occur without any added catalyst and consist of a cascade of reduction of the nitro group, sulfuration of a C-H of the double bond, oxidation of a sulfur atom to its highest ...
Thi Mo Nguyen, Hoang Anh Cao, Thi Thuong Thuong Cao, Satoki Koyama, Dinh Hung Mac, Thanh Binh Nguyen   +5 more
openaire   +2 more sources

1-Propyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide

Acta Crystallographica Section E, 2010
In the title compound, C11H13NO3S, a benzothiazine derivative, the heterocycle adopts a sofa conformation. In the crystal, weak C—H...O hydrogen bonds connect the molecules into a three-dimensional network.
Islam Ullah Khan, Muhammad Shafiq, Muhammad Nadeem Arshad   +2 more
doaj   +1 more source

3,3,6-Tribromo-1-methyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide

Acta Crystallographica Section E, 2010
In the title compound, C9H6Br3NO3S, a halogenated benzothiazine derivative, the thiazine ring adopts a sofa conformation. The crystal studied was a racemic twin with a contribution of 72 (1)% of the major domain.
Ghulam Mustafa, Muhammad Nadeem Arshad, Islam Ullah Khan, Muhammad Shafiq   +3 more
doaj   +1 more source