Results 11 to 20 of about 286 (167)

NorA Efflux Pump Inhibitors: Expanding SAR Knowledge of Pyrazolo[4,3-c][1,2]benzothiazine 5,5-Dioxide Derivatives. [PDF]

Arch Pharm (Weinheim)
Antimicrobial resistance (AMR) represents a significant global concern, driven by the overuse of antibiotics. One of the principal mechanisms contributing to AMR is the activity of microbial efflux pumps (EPs), which expel diverse antibiotics out of ...
Cernicchi G, Di Gregorio A, Felicetti T, Rampacci E, Casari G, Armeni T, Romaldi B, Zefaj E, Passamonti F, Massari S, Manfroni G, Barreca ML, Tabarrini O, Vignaroli C, Sabatini S.   +14 more
europepmc   +4 more sources

2,1-Benzothiazines : preparation and reactivity [PDF]

, 2018
Title from PDF of title page (University of Missouri--Columbia, viewed on May 24, 2010). ; The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. ; Dissertation advisor: Dr. Michael Harmata. ; Vita. ; Ph. D. University of Missouri--
Calkins, Nathan L., 1982-
openaire   +4 more sources

Synthesis of 1-ethyl-1H-2,1-benzothiazine 2,2-dioxide derivatives using cycloalkanecarbaldehydes and evaluation of their antimicrobial activity [PDF]

Chemistry of Heterocyclic Compounds, 2017
4,6-Dihydropyrano[3,2-c][2,1]benzothiazine 5,5-dioxides were synthesized via three-component interaction of 1-ethyl-1H-2,1-benzothiazin-4(3H)-one 2,2-dioxide with active methylene nitriles and cycloalkanecarbaldehydes. The latter were also applied to obtain ammonium salts of 3,3'-(cycloalkylmethanediyl)bis(1-ethyl-1H-2,1-benzothiazin-4-ol) 2,2,2',2 ...
Dmitry A. Lega, Valentine P. Chernykh, Lucjusz Zaprutko, Andrzej K. Gzella, Leonid A. Shemchuk   +4 more
core   +9 more sources

(R,S)-2′-Amino-6′-methyl-2,5′,5′-trioxo-6′H-spiro[indoline-3,4′-pyrano[3,2-c][2,1]benzothiazine]-3′-carbonitrile dimethylformamide monosolvate [PDF]

Acta Crystallographica Section E, 2014
The title solvate, C20H14N4O4S·C3H7NO, comprises a stereogenic centre but the centrosymmetric space group causes the presence of the racemate in the crystal. The spiro-joined fragments are almost orthogonal, with a dihedral angle of 86.8 (2)° between the
Svitlana V. Shishkina, Igor V. Ukrainets, Lidiya A. Petrushova   +2 more
doaj   +2 more sources

Synthesis of fluorescent 7-amino-2,1-benzothiazines and total synthesis of buddledone A [PDF]

, 2018
Title from PDF of title page (University of Missouri--Columbia, viewed on May 31, 2012). ; The entire thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file; a non-technical public abstract appears in the public.pdf file. ; Dissertation advisor: Dr. Michael Harmata ; Vita. ; Ph. D.
Yongpruksa, Nattawut
openaire   +4 more sources

Sulfoximine‐Directed Arene ortho‐Lithiation

European Journal of Organic Chemistry, Volume 2021, Issue 46, Page 6229-6246, December 14, 2021., 2021
The growing importance of sulfoximines in medicinal chemistry has led to a renewed interest in their synthesis and functionalization. This review describes the directed ortho‐lithiation of S‐aryl sulfoximines. Discussed are the synthesis and reactivity of five different types of o‐lithiosulfoximines, including o‐lithiosulfoximines with and without α ...
Hans‐Joachim Gais
wiley   +1 more source

Cyclization Reactions Involving 2‐Aminoarenetellurols and Derivatives of α,β‐Unsaturated Carboxylic Acids

Heteroatom Chemistry, Volume 2021, Issue 1, 2021., 2021
The reductive cyclization of arenetellurols carrying α,β‐unsaturated amide functionalities in the ortho position was investigated. Conceptually, such compounds can form 1,3‐tellurazoles without the involvement of the unsaturation in the ring closure, they can form 1,4‐tellurazinone derivatives, or they can undergo ring closure to 1,5‐tellurazepinones ...
Jayna A. Patel, Aundrea M. Lee, Donna V. Franklin, Frank R. Fronczek, Thomas Junk, Tieqiao Chen   +5 more
wiley   +1 more source

Synthesis and Antimicrobial Activity of 1,2-Benzothiazine Derivatives [PDF]

, 2016
© 2016 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC-BY) license (http://creativecommons.org/licenses/by/4.0/).A number of 1,2 ...
Ann Hunter, Bariş, Buwa, Chandani Patel, Chikhalia, Jatinder Bassin, Jenna Flye, Lee Martin, Madhu Goyal, Maheshwari, Mark Scott, Martinez, Rathod   +12 more
core   +5 more sources

3,3′-(Phenylmethylene)bis(1-ethyl-3,4-dihydro-1H-2,1-benzothiazine-2,2,4-trione): single-crystal X-ray diffraction study, quantum-chemical calculations and Hirshfeld surface analysis

Acta Crystallographica Section E: Crystallographic Communications, 2023
The title compound, C27H26N2O6S2, possesses potential antimicrobial, analgesic, and anti-inflammatory activity. This compound has three tautomeric forms, which relative energies were estimated with quantum-chemical calculations.
Mariia O. Shyshkina, Dmitry A. Lega, Liudmyla M. Shemchuk, Irina L. Starchikova, Leonid A. Shemchuk   +4 more
doaj   +1 more source

Methyl 4-Hydroxy-2,2-Dioxo-1H-2λ⁶,1-Benzothiazine-3-Carboxylate and Its Analogs Modified in the Benzene Moiety of the Molecule as New Analgesics

Scientia Pharmaceutica, 2020
In order to identify new regularities of the “structure−analgesic activity” relationship in the series of 2,1-benzothiazine derivatives, the synthesis of methyl 4-hydroxy-2,2-dioxo-1H-2λ6,1-benzothiazine-3-carboxylate and a group ...
Igor V. Ukrainets, Lidiya A. Petrushova, Svitlana V. Shishkina, Lyudmila V. Sidorenko, Tatiana V. Alekseeva, Inna I. Torianyk, Alexandra A. Davidenko   +6 more
doaj   +1 more source